SELPLG and TPST2

Number of citations of the paper that reports this interaction (PubMedID 17558413)
0

Data Source:
HPRD (in vitro)

		SELPLG	TPST2
Description		selectin P ligand	tyrosylprotein sulfotransferase 2
Image
GO Annotations	Cellular Component	Uropod Plasma Membrane Membrane Plasma Membrane Raft	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Golgi Lumen Trans-Golgi Network Membrane
	Molecular Function	Virus Receptor Activity Signaling Receptor Binding Protein Binding	Protein-tyrosine Sulfotransferase Activity Transferase Activity Protein Homodimerization Activity
	Biological Process	Cell Adhesion Symbiont Entry Into Host Cell Leukocyte Migration Leukocyte Tethering Or Rolling Leukocyte Adhesive Activation Cellular Response To Interleukin-6	Peptidyl-tyrosine Sulfation Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Prevention Of Polyspermy
Pathways		Cell surface interactions at the vascular wall	Cytosolic sulfonation of small molecules Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation Defective F8 sulfation at Y1699 Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)
Drugs		Neihulizumab
Diseases
GWAS		Acne (severe) ( 24927181) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Conduct disorder (symptom count) ( 20585324)	Anti-saccade response ( 29064472) Blood protein levels ( 30072576) Metabolite levels ( 23823483)
Interacting Genes		14 interacting genes: BACE1 CTSG GALNT4 MAGEA1 MSN SELE SELL SELP SLC13A1 SYK TNIP1 TPST1 TPST2 VCAN	7 interacting genes: CCR1 CCR8 CMKLR1 CMKLR2 GOLPH3 GOLPH3L SELPLG
Entrez ID		6404	8459
HPRD ID		02845	07217
Ensembl ID		ENSG00000110876	ENSG00000128294
Uniprot IDs		Q14242	O60704
PDB IDs		1G1S	3AP1 3AP2 3AP3
Enriched GO Terms of Interacting Partners?		Leukocyte Cell-cell Adhesion Leukocyte Migration Oligosaccharide Binding Carbohydrate Binding Leukocyte Tethering Or Rolling Sialic Acid Binding Protein-tyrosine Sulfotransferase Activity Leukocyte Adhesion To Vascular Endothelial Cell Cell-cell Adhesion Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Glycosphingolipid Binding Regulation Of Platelet Activation Cell Motility Positive Regulation Of Leukocyte Tethering Or Rolling Regulation Of Leukocyte Tethering Or Rolling 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Golgi Lumen Response To Lipopolysaccharide Immune System Process Phospholipase Binding Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Response To Molecule Of Bacterial Origin Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Immune System Process Neutrophil Activation Positive Regulation Of Receptor Internalization Regulation Of Platelet Aggregation Regulation Of Leukocyte Cell-cell Adhesion Heparin Binding Regulation Of Immune System Process Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Cellular Extravasation Pattern Recognition Receptor Signaling Pathway Regulation Of Inflammatory Response Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Innate Immune Response-activating Signaling Pathway Trans-Golgi Network Signaling Receptor Ligand Precursor Processing Response To Lipid Biofilm Matrix Disassembly Regulation Of Defense Response Mevalonate Kinase Activity Interleukin-15 Receptor Binding Positive Regulation Of Interleukin-3 Production Peptidyl-tyrosine Sulfation Golgi-associated Vesicle Lumen Activation Of Innate Immune Response Response To External Biotic Stimulus	Chemokine Receptor Activity Adipokinetic Hormone Binding Adipokinetic Hormone Receptor Activity Golgi Vesicle Budding Cargo Adaptor Activity Protein Targeting To Golgi Apparatus Chemokine-mediated Signaling Pathway Golgi Cisterna G Protein-coupled Receptor Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Leukocyte Tethering Or Rolling C-C Chemokine Binding C-C Chemokine Receptor Activity Leukocyte Adhesion To Vascular Endothelial Cell Phosphatidylinositol-4-phosphate Binding Vesicle Budding From Membrane Golgi To Plasma Membrane Protein Transport G Protein-coupled Receptor Signaling Pathway Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Cell Adhesion Cell Migration Chemotaxis Leukocyte Cell-cell Adhesion Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Locomotion Golgi Cisterna Membrane Cell Motility Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Chemotaxis Chemokine (C-C Motif) Ligand 5 Binding Chemokine (C-C Motif) Ligand 7 Binding Leukocyte Adhesive Activation Post-Golgi Vesicle-mediated Transport Asymmetric Golgi Ribbon Formation Golgi Organization Response To Cytokine Response To Peptide Cell Adhesion Molecule Production Cellular Response To Rapamycin Vesicle-mediated Transport To The Plasma Membrane Regulation Of Mononuclear Cell Migration Positive Regulation Of Chemotaxis Positive Regulation Of Protein Secretion Positive Regulation Of Leukocyte Migration Signaling Membrane Protein Retention In Golgi Apparatus
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