TIPIN and TIMELESS

Number of citations of the paper that reports this interaction (PubMedID 12875843)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		TIPIN	TIMELESS
Description		TIMELESS interacting protein	timeless circadian regulator
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Replication Fork Protection Complex	Chromatin Nucleus Nucleoplasm Chromosome Replication Fork Protection Complex Site Of Double-strand Break
	Molecular Function	DNA Binding Protein Binding	DNA Binding Protein Binding Enzyme Activator Activity Identical Protein Binding
	Biological Process	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Damage Response Positive Regulation Of Cell Population Proliferation Response To UV Replication Fork Processing Mitotic Intra-S DNA Damage Checkpoint Signaling Regulation Of Nuclear Cell Cycle DNA Replication Replication Fork Arrest Cell Cycle Phase Transition Cell Division	DNA Replication Checkpoint Signaling Morphogenesis Of An Epithelium DNA Repair DNA Damage Response Circadian Rhythm Detection Of Abiotic Stimulus Lung Development Replication Fork Processing Regulation Of Cell Population Proliferation Regulation Of Circadian Rhythm Replication Fork Arrest Cell Cycle Phase Transition Negative Regulation Of DNA-templated Transcription Rhythmic Process Branching Morphogenesis Of An Epithelial Tube Cell Division Cellular Response To Hydroxyurea Cellular Response To Cisplatin Cellular Response To Bleomycin Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Double-strand Break Repair
Pathways		Processing of DNA double-strand break ends	Processing of DNA double-strand break ends
Drugs
Diseases
GWAS		Adult body size ( 32376654) Testicular germ cell tumor ( 28604728 28604732)	Axial length ( 24144296) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Refractive error ( 32231278)
Interacting Genes		5 interacting genes: APP CLSPN GSC2 TEX11 TIMELESS	12 interacting genes: CHEK1 CLSPN CRY1 CRY2 PCBD1 PER1 PER2 PLK1 TF TIPIN WEE2-AS1 ZSCAN1
Entrez ID		54962	8914
HPRD ID		16917	04864
Ensembl ID		ENSG00000075131	ENSG00000111602
Uniprot IDs		B4DRF3 Q9BVW5	Q9UNS1
PDB IDs		7PFO 7PLO 8B9D	4XHT 4XHU 4XHW 5MQI 6T9Q 6TAZ 7PFO 7PLO 8B9D
Enriched GO Terms of Interacting Partners?		DNA Replication Checkpoint Signaling Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine DNA Binding Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Replication Fork Arrest DNA Metabolic Process Replication Fork Protection Complex Cellular Response To Cisplatin Cellular Response To Bleomycin Gene Conversion Male Meiosis Chromosome Segregation Meiotic Gene Conversion DNA Secondary Structure Binding Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Response To Bleomycin Negative Regulation Of Cell Cycle Phase Transition Response To Cisplatin Chiasma Assembly Axon Choice Point Recognition Regulation Of Cell Cycle Heparan Sulfate Binding Signaling Receptor Activator Activity	Photoperiodism Entrainment Of Circadian Clock By Photoperiod Entrainment Of Circadian Clock Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Signal Transduction In Response To DNA Damage Negative Regulation Of Circadian Rhythm Mitotic DNA Damage Checkpoint Signaling Circadian Regulation Of Gene Expression Mitotic DNA Integrity Checkpoint Signaling Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity DNA Damage Checkpoint Signaling Regulation Of Circadian Rhythm Cry-Per Complex Mitotic G2 DNA Damage Checkpoint Signaling Response To Light Stimulus Circadian Rhythm Negative Regulation Of Glucocorticoid Secretion Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Mitotic G2/M Transition Checkpoint DNA Damage Response Response To Blue Light Response To Radiation Regulation Of Cell Cycle Phase Transition Regulation Of Primary Metabolic Process Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Photoreceptor Activity Anaphase-promoting Complex Binding Rhythmic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Mitotic Nuclear Membrane Disassembly Negative Regulation Of Cell Cycle Process Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Kinase Binding Nuclear Membrane Disassembly Regulation Of G2/M Transition Of Mitotic Cell Cycle Membrane Disassembly Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Regulation Of Metabolic Process DNA Replication Checkpoint Signaling Regulation Of Cell Cycle Process DNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process
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