TIPIN and CLSPN

Number of citations of the paper that reports this interaction (PubMedID 20233725)
65

Data Source:
BioGRID (pull down, affinity chromatography technology)

		TIPIN	CLSPN
Description		TIMELESS interacting protein	claspin
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Replication Fork Protection Complex	Nucleus Nucleoplasm Golgi Apparatus
	Molecular Function	DNA Binding Protein Binding	DNA Secondary Structure Binding DNA Binding Protein Binding Anaphase-promoting Complex Binding
	Biological Process	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Damage Response Positive Regulation Of Cell Population Proliferation Response To UV Replication Fork Processing Mitotic Intra-S DNA Damage Checkpoint Signaling Regulation Of Nuclear Cell Cycle DNA Replication Replication Fork Arrest Cell Cycle Phase Transition Cell Division	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Repair DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Peptidyl-serine Phosphorylation Activation Of Protein Kinase Activity Mitotic DNA Replication Checkpoint Signaling
Pathways		Processing of DNA double-strand break ends	Apoptotic cleavage of cellular proteins Activation of ATR in response to replication stress Ub-specific processing proteases Processing of DNA double-strand break ends
Drugs
Diseases
GWAS		Adult body size ( 32376654) Testicular germ cell tumor ( 28604728 28604732)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		5 interacting genes: APP CLSPN GSC2 TEX11 TIMELESS	20 interacting genes: ATR BRCA1 CASP7 CDC45 CDC7 CHEK1 CSNK1G1 CSNK1G2 CSNK1G3 FZR1 POLE RAD17 RAD9A TIMELESS TIPIN TRIM21 USP20 USP28 USP29 USP7
Entrez ID		54962	63967
HPRD ID		16917	09257
Ensembl ID		ENSG00000075131	ENSG00000092853
Uniprot IDs		B4DRF3 Q9BVW5	Q9HAW4
PDB IDs		7PFO 7PLO 8B9D	7AKO 7PFO 7PLO 8B9D
Enriched GO Terms of Interacting Partners?		DNA Replication Checkpoint Signaling Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine DNA Binding Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Replication Fork Arrest DNA Metabolic Process Replication Fork Protection Complex Cellular Response To Cisplatin Cellular Response To Bleomycin Gene Conversion Male Meiosis Chromosome Segregation Meiotic Gene Conversion DNA Secondary Structure Binding Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Response To Bleomycin Negative Regulation Of Cell Cycle Phase Transition Response To Cisplatin Chiasma Assembly Axon Choice Point Recognition Regulation Of Cell Cycle Heparan Sulfate Binding Signaling Receptor Activator Activity	Negative Regulation Of Cell Cycle Phase Transition DNA Repair DNA Metabolic Process DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle Process DNA Damage Response Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Signal Transduction In Response To DNA Damage DNA Replication Checkpoint Signaling Cellular Response To Stress Mitotic DNA Damage Checkpoint Signaling Regulation Of Cell Cycle Process Mitotic DNA Integrity Checkpoint Signaling Regulation Of Cell Cycle Cell Cycle Phase Transition Response To Stress Regulation Of G2/M Transition Of Mitotic Cell Cycle Macromolecule Metabolic Process Negative Regulation Of Mitotic Cell Cycle Mitotic G2/M Transition Checkpoint Regulation Of Cell Cycle G2/M Phase Transition Intracellular Signal Transduction Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Negative Regulation Of Cell Cycle G2/M Phase Transition Nucleic Acid Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Mitotic Cell Cycle Signal Transduction Regulation Of DNA Replication Cysteine-type Peptidase Activity Nucleus Protein Modification Process Mitotic Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process Cysteine-type Endopeptidase Activity Mitotic Intra-S DNA Damage Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Protein Serine Kinase Activity Nucleoplasm Post-translational Protein Modification Deubiquitinase Activity Cysteine-type Deubiquitinase Activity Replication Fork Protection Complex Protein Deubiquitination Protein Serine/threonine Kinase Activity Replication Fork Arrest Mitotic G2 DNA Damage Checkpoint Signaling
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