ELMO2 and RHOG

Number of citations of the paper that reports this interaction (PMID 12879077)
76

Data Source:
HPRD (in vivo, in vitro)

		ELMO2	RHOG
Gene Name		engulfment and cell motility 2	ras homolog family member G
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Membrane	Cytosol Plasma Membrane Focal Adhesion Extracellular Vesicular Exosome
	Molecular Function	Protein Binding SH3 Domain Binding Receptor Tyrosine Kinase Binding	GTPase Activity Protein Binding GTP Binding
	Biological Process	Apoptotic Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Chemotaxis	Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Axon Guidance Blood Coagulation Metabolic Process Positive Regulation Of Cell Proliferation Rac Protein Signal Transduction Actin Cytoskeleton Organization Platelet Activation Activation Of Rac GTPase Activity Positive Regulation Of Transcription, DNA-templated Regulation Of Small GTPase Mediated Signal Transduction Cell Chemotaxis Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Regulation Of Ruffle Assembly
Pathways		Signaling by VEGF Fcgamma receptor (FCGR) dependent phagocytosis VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System	Signaling by GPCR Axon guidance Semaphorin interactions Rho GTPase cycle GPCR downstream signaling Signaling by Rho GTPases GPVI-mediated activation cascade G alpha (12/13) signalling events Sema4D in semaphorin signaling Platelet activation, signaling and aggregation Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: DOCK1 RHOG	19 interactors: ARHGDIA ARHGDIG DOCK1 ECT2 ELMO1 ELMO2 ELMOD2 IQGAP2 KTN1 MAP3K11 MCF2 MCF2L PLD1 SMAD1 SMAD4 TGFBR1 VAV1 VAV2 VAV3
Entrez ID		63916	391
HPRD ID		12103	01537
Ensembl ID		ENSG00000062598	ENSG00000177105
Uniprot IDs		B4DRL5 B4DZ20 F5GZP8 Q7Z5G9 Q96JJ3	P84095 Q6ICQ8
PDB IDs
Enriched GO Terms of Interacting Partners?		Axon Guidance Blood Coagulation Hemostasis Axonogenesis Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Chemotaxis Small GTPase Mediated Signal Transduction Neuron Projection Morphogenesis Response To Wounding Cell Morphogenesis Involved In Differentiation Positive Regulation Of GTPase Activity Activation Of Rac GTPase Activity Phagocytosis, Engulfment Regulation Of GTPase Activity Neuron Projection Development Cell Migration Cell Projection Morphogenesis Cell Part Morphogenesis Cell Motility Regulation Of Ruffle Assembly Membrane Invagination Rac Protein Signal Transduction Neuron Development Positive Regulation Of Hydrolase Activity Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Cell Morphogenesis Positive Regulation Of Protein Localization To Plasma Membrane Neuron Differentiation Cell Projection Organization Locomotion Activation Of Rho GTPase Activity Regulation Of Establishment Of Protein Localization To Plasma Membrane Movement Of Cell Or Subcellular Component Positive Regulation Of Catalytic Activity Regulation Of Protein Localization To Plasma Membrane Generation Of Neurons Activation Of Ras GTPase Activity Positive Regulation Of Rac GTPase Activity Rho Protein Signal Transduction Neurogenesis Cell Development Response To External Stimulus Intracellular Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Nervous System Development Regulation Of Cell Projection Assembly Regulation Of Catalytic Activity	Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Cellular Response To Growth Factor Stimulus Positive Regulation Of Catalytic Activity Response To Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Hydrolase Activity Cell Death Death Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Metabolic Process Phagocytosis Signal Transduction Apoptotic Process Programmed Cell Death Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Signaling Cell Surface Receptor Signaling Pathway Cell Communication Regulation Of Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Intracellular Signal Transduction Positive Regulation Of Ras GTPase Activity Positive Regulation Of Rho GTPase Activity Cellular Response To Stimulus Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Fc Receptor Signaling Pathway Regulation Of Rho GTPase Activity Response To Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Ras GTPase Activity Regulation Of Signal Transduction Response To Stress Regulation Of Rho Protein Signal Transduction Apoptotic Signaling Pathway Chemotaxis Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway
Tagcloud ?		adhesion adhesions cadherin canine completion contacts coordinate coordination darby dock dock1 dynamic exchange gtpase guanine integrin interference localize madin rac recruits reorganization requiring rho screen spreading subsequently unexpected	adam19 adamts16 adamts9 aggf1 altitude altitudes ccbe1 creld1 dahe dhp dwells f2rl1 fgf10 fgf5 foxm gdap1 gna14 involvements jmjd1c nrbf2 parp8 pla2g4a rtel1 sweeps vegfc vps13a wuzhishan wzsp zfpm2
Tagcloud (Difference) ?		adhesion adhesions cadherin canine completion contacts coordinate coordination darby dock dock1 dynamic exchange gtpase guanine integrin interference localize madin rac recruits reorganization requiring rho screen spreading subsequently unexpected	adam19 adamts16 adamts9 aggf1 altitude altitudes ccbe1 creld1 dahe dhp dwells f2rl1 fgf10 fgf5 foxm gdap1 gna14 involvements jmjd1c nrbf2 parp8 pla2g4a rtel1 sweeps vegfc vps13a wuzhishan wzsp zfpm2
Tagcloud (Intersection) ?