ELMO2 and DOCK4

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology)

		ELMO2	DOCK4
Description		engulfment and cell motility 2	dedicator of cytokinesis 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane	Nucleolus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Stereocilium Stereocilium Bundle Cell Projection Organelle Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding SH3 Domain Binding Receptor Tyrosine Kinase Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding SH3 Domain Binding PDZ Domain Binding Receptor Tyrosine Kinase Binding Small GTPase Binding
	Biological Process	Phagocytosis Apoptotic Process Actin Filament Organization Cell Motility Cell Chemotaxis	Small GTPase-mediated Signal Transduction Cell Chemotaxis Regulation Of Postsynapse Assembly Negative Regulation Of Vascular Associated Smooth Muscle Contraction Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways		Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases RHOG GTPase cycle FCGR3A-mediated phagocytosis	RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis (sporadic) ( 24529757) Body mass index (change over time) ( 25378290) C-reactive protein and white blood cell count ( 22788528) DHEAS levels ( 34748635) Migraine ( 27322543) Mild age-related type 2 diabetes ( 34737425) Refractive astigmatism ( 30306274) Refractive error ( 32231278) Response to fenofibrate ( 22890011) Total intracranial volume ( 31530798)
Interacting Genes		3 interacting genes: DOCK1 DOCK4 RHOG	4 interacting genes: ELMO2 FASLG GRB2 RNF115
Entrez ID		63916	9732
HPRD ID		12103	07407
Ensembl ID		ENSG00000062598	ENSG00000128512
Uniprot IDs		Q96JJ3	Q8N1I0
PDB IDs		6IDX 6IE1
Enriched GO Terms of Interacting Partners?		Regulation Of Postsynapse Assembly Regulation Of Postsynapse Organization Regulation Of Synapse Assembly Postsynapse Regulation Of Cell Junction Assembly Small GTPase-mediated Signal Transduction Regulation Of Synapse Organization Glutamatergic Synapse Intracellular Signaling Cassette SH3 Domain Binding Cell Migration Cell Motility Cell Chemotaxis Guanyl-nucleotide Exchange Factor Activity Negative Regulation Of Vascular Associated Smooth Muscle Contraction GTPase Activator Activity Small GTPase Binding Intracellular Signal Transduction Chemotaxis Locomotion Guanyl-nucleotide Exchange Factor Complex Stereocilium Bundle Regulation Of Vascular Associated Smooth Muscle Contraction Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Vasoconstriction Regulation Of Cellular Component Organization Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Negative Regulation Of Muscle Contraction Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Activation Of GTPase Activity Rac Protein Signal Transduction Myoblast Fusion Regulation Of Ruffle Assembly Phagocytosis, Engulfment Cell-cell Fusion Syncytium Formation By Plasma Membrane Fusion Organelle Syncytium Formation Positive Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Stereocilium Cortical Cytoskeleton Organization Membrane Invagination Positive Regulation Of Epithelial Cell Migration Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Smooth Muscle Contraction	Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway SH3 Domain Binding Guanyl-nucleotide Exchange Factor Adaptor Activity Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Grb2-EGFR Complex Retinal Cell Programmed Cell Death Positive Regulation Of Phospholipid Translocation Cytoplasmic Vesicle Lumen Inflammatory Cell Apoptotic Process Vesicle-mediated Transport Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Positive Regulation Of Toll-like Receptor Signaling Pathway Necroptotic Signaling Pathway Intracellular Chloride Ion Homeostasis Branching Involved In Labyrinthine Layer Morphogenesis Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Immune Response-activating Signaling Pathway Regulation Of Plasma Membrane Organization Death Receptor Binding Positive Regulation Of Phospholipid Transport Endosomal Lumen Acidification Necroptotic Process Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway Endocytosis Insulin Receptor Substrate Binding Activation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Chloride Ion Homeostasis Schwann Cell Development Programmed Necrotic Cell Death Monoatomic Anion Homeostasis Immune System Process Programmed Cell Death Involved In Cell Development Negative Regulation Of Toll-like Receptor Signaling Pathway
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