ARC and TBX18

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ARC	TBX18
Description		activity regulated cytoskeleton associated protein	T-box transcription factor 18
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane Cell Cortex Postsynaptic Density Actin Cytoskeleton Membrane Dendrite Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Cell Projection Neuronal Cell Body Dendritic Spine Membrane Raft Synapse Postsynaptic Membrane Neuronal Ribonucleoprotein Granule Glutamatergic Synapse Virus-like Capsid Extracellular Vesicle	Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Repressor Complex
	Molecular Function	RNA Binding MRNA Binding Structural Molecule Activity Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Endocytosis Cytoskeleton Organization Endoderm Development Long-term Memory Anterior/posterior Pattern Specification Cell Migration Regulation Of Cell Morphogenesis Regulation Of Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission MRNA Transport Protein Homooligomerization Long-term Synaptic Potentiation Dendritic Spine Morphogenesis Regulation Of Dendritic Spine Morphogenesis Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Vesicle-mediated Intercellular Transport Regulation Of Long-term Synaptic Potentiation Regulation Of Long-term Synaptic Depression	Negative Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Somitogenesis Sinoatrial Node Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Morphogenesis Of Embryonic Epithelium Neural Plate Anterior/posterior Regionalization Positive Regulation Of DNA-templated Transcription Smooth Muscle Cell Differentiation Sinoatrial Node Cell Fate Commitment Sinoatrial Node Cell Development Ureter Development Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Regulation Of SA Node Cell Action Potential
Pathways		NGF-stimulated transcription NGF-stimulated transcription
Drugs
Diseases
GWAS		Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Automobile speeding propensity ( 30643258)	Diabetic retinopathy in type 2 diabetes ( 25364816) Lung function ( 31902109) Monobrow ( 27182965) Pulse pressure ( 30224653) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		7 interacting genes: CSRP2 KRT15 S100P SH2D4A SPTBN4 TBX18 UBE3A	4 interacting genes: ARC KRTAP8-1 PLEKHG4 TRAF1
Entrez ID		23237	9096
HPRD ID		12469	19076
Ensembl ID		ENSG00000198576	ENSG00000112837
Uniprot IDs		Q7LC44	O95935
PDB IDs		6TN7 6TNQ 6TQ0 6YTU 7R1Z 7R23 8QF4 8QF5
Enriched GO Terms of Interacting Partners?		Sperm Entry Positive Regulation Of Golgi Lumen Acidification Sinoatrial Node Cell Fate Commitment Phosphatase Binding Muscle Tissue Development Tissue Development Structural Constituent Of Cytoskeleton Positive Regulation Of Protein Localization To Lysosome Positive Regulation Of Cellular PH Reduction Regulation Of Golgi Lumen Acidification Ureter Development RNA Polymerase II Transcription Repressor Complex Sinoatrial Node Cell Development Neural Plate Pattern Specification Sinoatrial Node Development Cardiac Muscle Cell Fate Commitment Regulation Of SA Node Cell Action Potential Neural Plate Anterior/posterior Regionalization Cytoskeletal Protein-membrane Anchor Activity Clustering Of Voltage-gated Sodium Channels Axon Hillock Cell Body Fiber Paranode Region Of Axon Spectrin	Virus-like Capsid
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