GOT2 and MDH2

Number of citations of the paper that reports this interaction (PubMedID 2899080)
0

Data Source:
HPRD (in vitro)

		GOT2	MDH2
Description		glutamic-oxaloacetic transaminase 2	malate dehydrogenase 2
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Plasma Membrane Membrane Extracellular Exosome	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Membrane Extracellular Exosome
	Molecular Function	RNA Binding Catalytic Activity L-aspartate:2-oxoglutarate Aminotransferase Activity Transaminase Activity Kynurenine-oxoglutarate Transaminase Activity Transferase Activity Pyridoxal Phosphate Binding	RNA Binding Catalytic Activity Oxidoreductase Activity Malate Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor L-malate Dehydrogenase (NAD+) Activity Identical Protein Binding L-malate Dehydrogenase (NADP+) Activity
	Biological Process	2-oxoglutarate Metabolic Process Oxaloacetate Metabolic Process Amino Acid Metabolic Process Aspartate Metabolic Process Aspartate Biosynthetic Process L-aspartate Catabolic Process Glutamate Metabolic Process L-glutamate Catabolic Process Lipid Transport Fatty Acid Transport Trans-4-hydroxy-L-proline Catabolic Process L-glutamate Catabolic Process To Aspartate Malate-aspartate Shuttle Response To Ethanol	Gluconeogenesis Tricarboxylic Acid Cycle Malate Metabolic Process Aerobic Respiration NAD+ Metabolic Process Carboxylic Acid Metabolic Process Malate-aspartate Shuttle
Pathways		Degradation of cysteine and homocysteine Glyoxylate metabolism and glycine degradation Aspartate and asparagine metabolism Glutamate and glutamine metabolism Malate-aspartate shuttle	Citric acid cycle (TCA cycle) Mitochondrial protein degradation Malate-aspartate shuttle
Drugs		Pyridoxal phosphate Aspartic acid Glutamic acid Cysteine 4'-Deoxy-4'-Acetylyamino-Pyridoxal-5'-Phosphate	NADH Citric acid Xanthinol
Diseases
GWAS		Aortic root size ( 21223598) Aspartate aminotransferase levels ( 29403010 33339817 33547301) Automobile speeding propensity ( 30643258) High density lipoprotein cholesterol levels ( 33339817) Impulsivity (attentional) ( 30718321) Metabolite levels ( 23823483) QT interval ( 19305408) Serum metabolite levels ( 33031748) Triglyceride levels ( 32203549) Urinary metabolite levels in chronic kidney disease ( 31959995) Uterine fibroid number (single vs multiple) ( 30196971)	Coffee consumption ( 31959922)
Interacting Genes		10 interacting genes: APCS CCL21 GAPDH GLRX GLUD1 HSPA8 MDH2 PC THOC7 ZDHHC6	11 interacting genes: CRYAB CS FH GOT2 HSPB1 LINC00632 NDUFS1 PC PSMA1 SHANK3 WARS1
Entrez ID		2806	4191
HPRD ID		00684	01099
Ensembl ID		ENSG00000125166	ENSG00000146701
Uniprot IDs		P00505	A0A024R4K3 B3KTM1 G3XAL0 P40926
PDB IDs		5AX8 8SKR	2DFD 4WLE 4WLF 4WLN 4WLO 4WLU 4WLV
Enriched GO Terms of Interacting Partners?		Glucose Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Nicotinamide Nucleotide Metabolic Process Purine Nucleotide Metabolic Process Nucleotide Metabolic Process Hexose Metabolic Process Small Molecule Metabolic Process Monosaccharide Metabolic Process Purine-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleoside Phosphate Metabolic Process Chaperone-mediated Autophagy Translocation Complex Disassembly NAD+ Metabolic Process L-malate Dehydrogenase (NADP+) Activity Hexose Biosynthetic Process Gluconeogenesis Pyruvate Carboxylase Activity Dendritic Cell Dendrite Assembly Negative Regulation Of Dendritic Cell Dendrite Assembly Host-mediated Perturbation Of Viral Process Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Peptidyl-cysteine S-trans-nitrosylation Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Glutathione Disulfide Oxidoreductase Activity Glutamate Dehydrogenase (NAD+) Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, NAD Or NADP As Acceptor Glutamate Dehydrogenase (NADP+) Activity Glutamate Dehydrogenase [NAD(P)+] Activity Lumenal Side Of Lysosomal Membrane Viral RNA Genome Packaging Positive Regulation Of Myeloid Dendritic Cell Chemotaxis Mesangial Cell-matrix Adhesion CCR7 Chemokine Receptor Binding CCL21-activated CCR7 Signaling Pathway Cerebral Cortex Development Dicarboxylic Acid Metabolic Process Protein Kinase CK2 Complex Peptidyl-cysteine S-nitrosylase Activity Regulation Of Protein Import L-malate Dehydrogenase (NAD+) Activity Malate Dehydrogenase Activity Regulation Of Dendritic Cell Dendrite Assembly Unfolded Protein Binding Host-mediated Perturbation Of Symbiont Process Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Carbohydrate Metabolic Process Peptidyl-cysteine S-nitrosylation GAIT Complex Mitochondrial Matrix Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy	Mitochondrial Matrix Contractile Muscle Fiber Extracellular Exosome Protein Refolding Tricarboxylic Acid Cycle Mitochondrion NAD+ Metabolic Process Citrate Synthase Activity Fumarate Metabolic Process Fumarate Hydratase Activity Amino Acid Metabolic Process Negative Regulation Of Protein Kinase C Signaling Pyruvate Carboxylase Activity Small Molecule Metabolic Process Acyltransferase Activity, Acyl Groups Converted Into Alkyl On Transfer Catalytic Activity L-glutamate Catabolic Process To Aspartate L-aspartate:2-oxoglutarate Aminotransferase Activity Aspartate Biosynthetic Process Purine Nucleotide Metabolic Process Proteasome Complex Viral RNA Genome Packaging Tryptophan-tRNA Ligase Activity Tryptophanyl-tRNA Aminoacylation Guanylate Kinase-associated Protein Clustering Response To Heat Dicarboxylic Acid Metabolic Process L-aspartate Catabolic Process Nucleotide Metabolic Process Protein Kinase C Inhibitor Activity Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Unfolded Protein Binding Z Disc Citrate Metabolic Process Regulation Of Arginine Metabolic Process Nicotinamide Nucleotide Metabolic Process Trans-4-hydroxy-L-proline Catabolic Process Kynurenine-oxoglutarate Transaminase Activity Purine-containing Compound Metabolic Process Regulation Of Protein Kinase C Signaling Ligase Activity Biotin Binding Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering Synaptic Receptor Adaptor Activity NMDA Glutamate Receptor Clustering
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