GOT2

Name	glutamic-oxaloacetic transaminase 2
Structure
Novel Interactors	2 novel interactors: BBS2 CSNK2A2
Interactors	10 interactors: APCS CCL21 GAPDH GLRX GLUD1 HSPA8 MDH2 PC THOC7 ZDHHC6
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	RNA Binding Catalytic Activity L-aspartate:2-oxoglutarate Aminotransferase Activity Transaminase Activity Kynurenine-oxoglutarate Transaminase Activity Transferase Activity Pyridoxal Phosphate Binding
	Biological Process	2-oxoglutarate Metabolic Process Oxaloacetate Metabolic Process Amino Acid Metabolic Process Aspartate Metabolic Process Aspartate Biosynthetic Process L-aspartate Catabolic Process Glutamate Metabolic Process L-glutamate Catabolic Process Lipid Transport Fatty Acid Transport Trans-4-hydroxy-L-proline Catabolic Process L-glutamate Catabolic Process To Aspartate Malate-aspartate Shuttle Response To Ethanol
Pathways	Degradation of cysteine and homocysteine Glyoxylate metabolism and glycine degradation Aspartate and asparagine metabolism Glutamate and glutamine metabolism Malate-aspartate shuttle
Drugs	Pyridoxal phosphate Aspartic acid Glutamic acid Cysteine 4'-Deoxy-4'-Acetylyamino-Pyridoxal-5'-Phosphate
GWAS	Aortic root size ( 21223598 ) Aspartate aminotransferase levels ( 29403010 33339817 33547301 ) Automobile speeding propensity ( 30643258 ) High density lipoprotein cholesterol levels ( 33339817 ) Impulsivity (attentional) ( 30718321 ) Metabolite levels ( 23823483 ) QT interval ( 19305408 ) Serum metabolite levels ( 33031748 ) Triglyceride levels ( 32203549 ) Urinary metabolite levels in chronic kidney disease ( 31959995 ) Uterine fibroid number (single vs multiple) ( 30196971 )
Entrez ID	2806
HPRD ID	00684
Ensembl ID	ENSG00000125166
Uniprot IDs	P00505
PDB IDs	5AX8 8SKR
GO Terms Enriched among Interactors ?	Glucose Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Nicotinamide Nucleotide Metabolic Process Purine Nucleotide Metabolic Process Nucleotide Metabolic Process Hexose Metabolic Process Small Molecule Metabolic Process Monosaccharide Metabolic Process Purine-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleoside Phosphate Metabolic Process Chaperone-mediated Autophagy Translocation Complex Disassembly NAD+ Metabolic Process L-malate Dehydrogenase (NADP+) Activity Hexose Biosynthetic Process Gluconeogenesis Pyruvate Carboxylase Activity Dendritic Cell Dendrite Assembly Negative Regulation Of Dendritic Cell Dendrite Assembly Host-mediated Perturbation Of Viral Process Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Peptidyl-cysteine S-trans-nitrosylation Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Glutathione Disulfide Oxidoreductase Activity Glutamate Dehydrogenase (NAD+) Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, NAD Or NADP As Acceptor Glutamate Dehydrogenase (NADP+) Activity Glutamate Dehydrogenase [NAD(P)+] Activity Lumenal Side Of Lysosomal Membrane Viral RNA Genome Packaging Positive Regulation Of Myeloid Dendritic Cell Chemotaxis Mesangial Cell-matrix Adhesion CCR7 Chemokine Receptor Binding CCL21-activated CCR7 Signaling Pathway Cerebral Cortex Development Dicarboxylic Acid Metabolic Process Protein Kinase CK2 Complex Peptidyl-cysteine S-nitrosylase Activity Regulation Of Protein Import L-malate Dehydrogenase (NAD+) Activity Malate Dehydrogenase Activity Regulation Of Dendritic Cell Dendrite Assembly Unfolded Protein Binding Host-mediated Perturbation Of Symbiont Process Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Carbohydrate Metabolic Process Peptidyl-cysteine S-nitrosylation GAIT Complex Mitochondrial Matrix Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy