GOT2 and APCS

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		GOT2	APCS
Gene Name		glutamic-oxaloacetic transaminase 2, mitochondrial	amyloid P component, serum
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Plasma Membrane Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Nucleus Extracellular Matrix Protein Complex Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	L-aspartate:2-oxoglutarate Aminotransferase Activity Kynurenine-oxoglutarate Transaminase Activity Pyridoxal Phosphate Binding Poly(A) RNA Binding L-phenylalanine:2-oxoglutarate Aminotransferase Activity	Complement Component C1q Binding Calcium Ion Binding Carbohydrate Binding Virion Binding Unfolded Protein Binding
	Biological Process	Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis 2-oxoglutarate Metabolic Process Oxaloacetate Metabolic Process Aspartate Metabolic Process Aspartate Biosynthetic Process Aspartate Catabolic Process Glutamate Metabolic Process Cellular Amino Acid Biosynthetic Process Pathogenesis Fatty Acid Transport 4-hydroxyproline Catabolic Process Glutamate Catabolic Process To Aspartate Glutamate Catabolic Process To 2-oxoglutarate Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Response To Ethanol L-kynurenine Metabolic Process	Negative Regulation Of Acute Inflammatory Response Protein Folding Acute-phase Response Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Innate Immune Response Negative Regulation Of Monocyte Differentiation Negative Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Process Chaperone-mediated Protein Complex Assembly Negative Regulation Of Wound Healing Negative Regulation Of Exo-alpha-sialidase Activity Negative Regulation Of Glycoprotein Metabolic Process
Pathways		Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Amino acid synthesis and interconversion (transamination) Metabolism of carbohydrates Metabolism of amino acids and derivatives	Amyloids
Drugs		Pyridoxal Phosphate L-Aspartic Acid L-Glutamic Acid 4\'-Deoxy-4\'-Acetylyamino-Pyridoxal-5\'-Phosphate	Methyl 4,6-O-[(1r)-1-Carboxyethylidene]-Beta-D-Galactopyranoside BIS-1,2-{[(Z)-2-CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBAMOYL}-ETHANE BIS-1,2-{[(Z)-2CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBONYL}-PIPERAZINE
Diseases
GWAS		Aortic root size ( 21223598) QT interval ( 19305408)	C-reactive protein ( 22939635)
Protein-Protein Interactions		10 interactors: APCS CCL21 GAPDH GLRX GLUD1 HSPA8 MDH2 PC THOC7 ZDHHC6	17 interactors: C1QA C4BPA CALU COL4A1 COPS5 CRP FCGR1A FCGR2B FCGR3A FCGR3B FN1 GK GOT2 GRB2 HES1 LAMA1 TG
Entrez ID		2806	325
HPRD ID		00684	00101
Ensembl ID		ENSG00000125166	ENSG00000132703
Uniprot IDs		E7ERW2 P00505	P02743
PDB IDs			1GYK 1LGN 1SAC 2A3W 2A3X 2A3Y 2W08 3D5O 3KQR 4AVS 4AVT 4AVV 4AYU
Enriched GO Terms of Interacting Partners?		Gluconeogenesis Hexose Biosynthetic Process Dicarboxylic Acid Metabolic Process Oxaloacetate Metabolic Process Glucose Metabolic Process Carbohydrate Biosynthetic Process Pathogenesis Hexose Metabolic Process Monosaccharide Metabolic Process Tricarboxylic Acid Metabolic Process Protein Deglutathionylation Positive Regulation Of Myeloid Dendritic Cell Chemotaxis Negative Regulation Of Dendritic Cell Dendrite Assembly Dendritic Cell Dendrite Assembly Negative Regulation Of Fibril Organization Peptidyl-cysteine S-trans-nitrosylation Carboxylic Acid Metabolic Process Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Mesangial Cell-matrix Adhesion Negative Regulation Of Exo-alpha-sialidase Activity Organic Acid Metabolic Process Pyruvate Metabolic Process Regulation Of Dendritic Cell Dendrite Assembly Regulation Of Fibril Organization Small Molecule Metabolic Process Negative Regulation Of Leukocyte Tethering Or Rolling Clathrin Coat Disassembly Peptidyl-cysteine S-nitrosylation Establishment Of T Cell Polarity Oxidation-reduction Process Negative Regulation Of Monocyte Differentiation Glutamate Catabolic Process Positive Regulation Of Dendritic Cell Chemotaxis Cellular Metabolic Process Positive Regulation Of Transport Viral MRNA Export From Host Cell Nucleus Glutamate Biosynthetic Process Cellular Protein Metabolic Process Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Negative Regulation Of Locomotion Biotin Metabolic Process Positive Regulation Of Pseudopodium Assembly Negative Regulation Of Glycoprotein Metabolic Process Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Dicarboxylic Acid Catabolic Process Chaperone-mediated Protein Complex Assembly Protein Folding Regulation Of Monocyte Differentiation Dendritic Cell Chemotaxis	Immune System Process Immune Response Regulation Of Immune Response Regulation Of Immune System Process Positive Regulation Of Immune System Process Vesicle-mediated Transport Positive Regulation Of Immune Response Retinal Blood Vessel Morphogenesis Response To Stimulus Defense Response Phagocytosis Retina Vasculature Morphogenesis In Camera-type Eye Endocytosis Complement Activation, Classical Pathway Transport Cell Morphogenesis Involved In Differentiation Humoral Immune Response Mediated By Circulating Immunoglobulin Retina Vasculature Development In Camera-type Eye Complement Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Innate Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Blood Vessel Morphogenesis Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Platelet Activation Acute-phase Response Morphogenesis Of An Epithelium Blood Vessel Development Vasculature Development Generation Of Neurons Humoral Immune Response Morphogenesis Of A Branching Epithelium Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Neurogenesis Morphogenesis Of A Branching Structure Wound Healing Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Negative Regulation Of Pancreatic A Cell Differentiation Pharyngeal Arch Artery Morphogenesis Glycerol-3-phosphate Biosynthetic Process Lateral Inhibition Labyrinthine Layer Development Leukocyte Mediated Immunity Adaptive Immune Response Fc Receptor Signaling Pathway
Tagcloud ?		aggravating anxa1 banks bedside confidently cons fth1 ftl gliosis immunochemical infarct infarcted infarcts itraq lagging leak malate mdh2 mortem plex pros proteome proteomics putamen shuttle slc25a11 slc25a12 tca vim	aggregates cd68 dendritic dysmaturation dysmorphic enlarged fdc fdcs follicle follicles idc idcs imply interdigitating intima ki67 kim lining lymphocyte lymphocytes pathogenetic phenomena proliferating regarded rheumatoid semiquantitative slcs synovial vicinity
Tagcloud (Difference) ?		aggravating anxa1 banks bedside confidently cons fth1 ftl gliosis immunochemical infarct infarcted infarcts itraq lagging leak malate mdh2 mortem plex pros proteome proteomics putamen shuttle slc25a11 slc25a12 tca vim	aggregates cd68 dendritic dysmaturation dysmorphic enlarged fdc fdcs follicle follicles idc idcs imply interdigitating intima ki67 kim lining lymphocyte lymphocytes pathogenetic phenomena proliferating regarded rheumatoid semiquantitative slcs synovial vicinity
Tagcloud (Intersection) ?