DCTN3

Gene Name		dynactin 3 (p22)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Chromosome Kinetochore Centrosome Spindle Cytosol Dynactin Complex Midbody Cleavage Furrow Perinuclear Region Of Cytoplasm
	Molecular Function	Structural Molecule Activity Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Cytokinesis Organelle Organization Microtubule-based Process Mitotic Nuclear Division Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Pathways		Organelle biogenesis and maintenance Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes Adaptive Immune System
Drugs
Diseases
GWAS
Protein-protein Interactions		4 interactors: ATXN1 DCTN1 GSK3B PBX2
Entrez ID		11258
HPRD ID		06303
Ensembl ID		ENSG00000137100
Uniprot IDs		O75935
PDB IDs
Enriched GO Terms of Interacting Partners?		ER-nucleus Signaling Pathway Positive Regulation Of Cellular Metabolic Process Nuclear Export Response To Endoplasmic Reticulum Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development Positive Regulation Of Metabolic Process Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Hypermethylation Of CpG Island Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Nucleocytoplasmic Transport Nuclear Transport Cellular Response To Interleukin-3 Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Transport Positive Regulation Of Gene Expression Regulation Of Neuron Maturation Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Cellular Biosynthetic Process Protein Localization To Microtubule Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Dendrite Morphogenesis Negative Regulation Of NFAT Protein Import Into Nucleus Negative Regulation Of Phosphorylation ER Overload Response Negative Regulation Of Cardiac Muscle Hypertrophy Multicellular Organismal Development Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Muscle Hypertrophy Regulation Of Glycogen (starch) Synthase Activity Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Establishment Of Localization In Cell Positive Regulation Of Protein Export From Nucleus Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Dendrite Development Developmental Process Regulation Of DNA Methylation Myoblast Fusion Protein Localization To Cytoskeleton Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Localization Regulation Of Gene Expression By Genetic Imprinting
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