DCTN3 and CCL19

		DCTN3	CCL19
Description		dynactin subunit 3	C-C motif chemokine ligand 19
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromosome Nucleolus Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Dynactin Complex Microtubule Associated Complex Midbody Cleavage Furrow Perinuclear Region Of Cytoplasm	Extracellular Region Extracellular Space
	Molecular Function	Structural Molecule Activity Protein Binding	Cytokine Activity Protein Binding Chemokine Activity CCR7 Chemokine Receptor Binding CCR10 Chemokine Receptor Binding Chemokine Receptor Binding CCR Chemokine Receptor Binding
	Biological Process	Mitotic Cell Cycle Microtubule-based Process Cell Division Cytoskeleton-dependent Cytokinesis	Establishment Of T Cell Polarity Immunological Synapse Formation Dendritic Cell Chemotaxis Myeloid Dendritic Cell Chemotaxis Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Intracellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Cell Communication Response To Virus Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Cell Migration T Cell Costimulation Killing Of Cells Of Another Organism Regulation Of Cdc42 Protein Signal Transduction Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Rac Protein Signal Transduction CCL19-activated CCR7 Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Endocytosis Positive Regulation Of JNK Cascade Eosinophil Chemotaxis Positive Regulation Of Receptor-mediated Endocytosis Cell Maturation Positive Regulation Of Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Projection Assembly Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Prostaglandin E Stimulus Response To Nitric Oxide Positive Regulation Of Neutrophil Chemotaxis Mature Conventional Dendritic Cell Differentiation Cellular Response To Virus Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Dendritic Cell Dendrite Assembly Negative Regulation Of Dendritic Cell Apoptotic Process
Pathways		MHC class II antigen presentation Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic AURKA Activation by TPX2	Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823)	Metabolite levels ( 23823483) Rheumatoid arthritis ( 24390342 30423114)
Interacting Genes		11 interacting genes: ATXN1 DCTN1 GSK3B KRT34 NUP54 PBX2 PITX1 TRIM55 TRIP13 USHBP1 VPS37C	8 interacting genes: ACKR2 ACKR4 CCL22 CCR10 CCR7 CXCL13 MEOX2 PF4V1
Entrez ID		11258	6363
HPRD ID		06303	03750
Ensembl ID		ENSG00000137100	ENSG00000172724
Uniprot IDs		O75935 X6RLR1	Q6IBD6 Q99731
PDB IDs			2MP1 7STA
Enriched GO Terms of Interacting Partners?		Regulation Of Dendritic Cell Dendrite Assembly CCR7 Chemokine Receptor Binding Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Establishment Of T Cell Polarity Negative Regulation Of Dendritic Cell Apoptotic Process Chemokine Receptor Binding Establishment Of Cell Polarity Immunological Synapse Formation Dendritic Cell Chemotaxis Mononuclear Cell Migration Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Glycoprotein Biosynthetic Process Cellular Response To Prostaglandin E Stimulus Eosinophil Chemotaxis Positive Regulation Of Glycoprotein Metabolic Process Eosinophil Migration Myeloid Leukocyte Migration Regulation Of Antigen Processing And Presentation Dendritic Cell Migration Positive Regulation Of Neutrophil Chemotaxis Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Cell Maturation Positive Regulation Of Granulocyte Chemotaxis CCR Chemokine Receptor Binding Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Neutrophil Migration Regulation Of Neutrophil Chemotaxis Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cellular Component Biogenesis Neuron Projection Organization Tau Protein Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Developmental Maturation Regulation Of Neutrophil Migration T Cell Costimulation Chemokine Activity Leukocyte Migration Regulation Of Cell Projection Assembly Regulation Of Granulocyte Chemotaxis Regulation Of Microtubule Anchoring At Centrosome Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Dendritic Cell Dendrite Assembly Dendritic Cell Dendrite Assembly Negative Regulation Of Dendritic Cell Dendrite Assembly Negative Regulation Of Leukocyte Apoptotic Process Release Of Sequestered Calcium Ion Into Cytosol Cell-cell Recognition	Chemokine-mediated Signaling Pathway Cell Chemotaxis C-C Chemokine Receptor Activity Chemokine Receptor Activity Chemotaxis Locomotion Cytokine-mediated Signaling Pathway Myeloid Leukocyte Migration Positive Regulation Of Cytosolic Calcium Ion Concentration External Side Of Plasma Membrane Cell Migration C-C Chemokine Binding Leukocyte Migration Immune System Process Cell Motility G Protein-coupled Receptor Signaling Pathway Leukocyte Chemotaxis Inflammatory Response Chemokine Activity Calcium-mediated Signaling G Protein-coupled Receptor Activity Galactose Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Granulocyte Chemotaxis Cell Surface Receptor Signaling Pathway CXCR Chemokine Receptor Binding Cellular Response To Lipid Granulocyte Migration Immune Response Mononuclear Cell Migration Response To Lipopolysaccharide Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Response To Molecule Of Bacterial Origin Antimicrobial Humoral Response C-C Motif Chemokine 19 Receptor Activity Chemokine (C-C Motif) Ligand 19 Binding Positive Regulation Of Glycoprotein Biosynthetic Process Involved In Immunological Synapse Formation Chemokine (C-C Motif) Ligand 21 Binding C-C Motif Chemokine 21 Receptor Activity UDP-glucose:hexose-1-phosphate Uridylyltransferase Activity Positive Regulation Of Circulating Fibrinogen Levels Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Negative Regulation Of Ectodermal Cell Fate Specification CXCR5 Chemokine Receptor Binding Lymphocyte Chemotaxis Across High Endothelial Venule Endothelial Cell Chemotaxis To Fibroblast Growth Factor Response To Lipid Regulation Of Humoral Immune Response Signal Transduction
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