IGFBP7 and CHMP3

Number of citations of the paper that reports this interaction (PubMedID 11549700)
0

Data Source:
HPRD (in vivo)

		IGFBP7	CHMP3
Description		insulin like growth factor binding protein 7	charged multivesicular body protein 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Exosome	Autophagosome Membrane Kinetochore ESCRT III Complex Nuclear Pore Cytoplasm Lysosomal Membrane Endosome Early Endosome Late Endosome Multivesicular Body Kinetochore Microtubule Cytosol Plasma Membrane Membrane Midbody Cytoplasmic Vesicle Late Endosome Membrane Multivesicular Body Membrane Extracellular Exosome Amphisome Membrane
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Insulin-like Growth Factor Binding Growth Factor Binding Receptor Ligand Activity	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylcholine Binding Identical Protein Binding Molecular Function Inhibitor Activity Ubiquitin-specific Protease Binding
	Biological Process	Angiogenesis Regulation Of Cell Growth Cell Adhesion Signal Transduction Embryo Implantation Negative Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Response To Retinoic Acid Cellular Response To Hormone Stimulus Regulation Of Steroid Biosynthetic Process Response To Cortisol Cellular Response To Prostaglandin E Stimulus	Plasma Membrane Repair Autophagy Apoptotic Process Nucleus Organization Vacuolar Transport Mitotic Metaphase Chromosome Alignment Endosome To Lysosome Transport Regulation Of Centrosome Duplication Protein Transport Macroautophagy Viral Release From Host Cell Nuclear Membrane Reassembly Positive Regulation Of Cytokinesis Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Suppression Of Viral Release By Host Late Endosome To Vacuole Transport Viral Budding From Plasma Membrane Regulation Of Endosome Size Protein Polymerization Cell Division Vesicle Fusion With Vacuole Multivesicular Body-lysosome Fusion Midbody Abscission Multivesicular Body Sorting Pathway Membrane Fission Autophagosome Maturation Regulation Of Mitotic Spindle Assembly Late Endosome To Lysosome Transport Regulation Of Exosomal Secretion Regulation Of Early Endosome To Late Endosome Transport
Pathways		Senescence-Associated Secretory Phenotype (SASP) Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Budding and maturation of HIV virion Macroautophagy Pyroptosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex
Drugs		Insulin human
Diseases
GWAS		Age-related macular degeneration ( 21909106) Alcohol consumption (max-drinks) ( 29460428) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) Brain volume in infants (grey matter) ( 28763065) Congenital heart disease (maternal effect) ( 28468790) Diastolic blood pressure ( 30224653) Heel bone mineral density ( 28869591) Hyperemesis gravidarum ( 29563502) Schizophrenia x sex interaction ( 34099189) Severity of nausea and vomiting of pregnancy ( 29563502)	Adult body size ( 32376654) Glomerular filtration rate in chronic kidney disease ( 26420894) Nicotine dependence symptom count ( 25555482)
Interacting Genes		11 interacting genes: CCL21 CCL5 CHMP3 CXCL10 IGF1 IGF2 INHBA INS RBBP8 SDC1 VEGFA	14 interacting genes: APP CHMP2A CHMP2B CHMP4A CHMP4B FBXO7 HSPA13 IGFBP7 RAB11A SMAD1 SMAD5 STAMBP TNPO3 VAV2
Entrez ID		3490	51652
HPRD ID		04183	15650
Ensembl ID		ENSG00000163453	ENSG00000115561
Uniprot IDs		Q16270	Q9Y3E7
PDB IDs		8IVD	2GD5 2XZE 3FRT 3FRV 7ZCG 7ZCH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Transport Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Transport Insulin-like Growth Factor Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Positive Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Positive Regulation Of Glycogen Biosynthetic Process Cytokine Activity Granulocyte Chemotaxis Regulation Of T Cell Chemotaxis Extracellular Region Granulocyte Migration Positive Regulation Of Leukocyte Chemotaxis Insulin Receptor Binding Extracellular Space Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Cell Migration Regulation Of Secretion By Cell Hormone Activity Positive Regulation Of Cell Motility Regulation Of Immune System Process Positive Regulation Of Locomotion Regulation Of Glycogen Biosynthetic Process Regulation Of Secretion Receptor Ligand Activity Myeloid Leukocyte Migration Chemoattractant Activity Regulation Of Cellular Component Organization Regulation Of MAPK Cascade Leukocyte Chemotaxis Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of T Cell Migration Positive Regulation Of Chemotaxis Positive Regulation Of Leukocyte Migration Regulation Of Glycogen Metabolic Process Growth Factor Activity Regulation Of Cell Cycle Process Positive Regulation Of Lymphocyte Migration Positive Chemotaxis Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Mitotic Nuclear Division Regulation Of T Cell Migration Chemokine Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Epithelial Cell Proliferation Cell Chemotaxis Regulation Of Apoptotic Process	Kinetochore Microtubule Multivesicular Body Organization Multivesicular Body Assembly ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Multivesicular Body-lysosome Fusion Multivesicular Body Mitotic Metaphase Chromosome Alignment Viral Budding From Plasma Membrane Lysosomal Membrane Organization Metaphase Chromosome Alignment Late Endosome To Lysosome Transport Viral Budding Via Host ESCRT Complex Regulation Of Mitotic Spindle Assembly Midbody Abscission Viral Budding Nuclear Membrane Reassembly Chromosome Localization Mitotic Cytokinetic Process Endosome Organization Multivesicular Body Membrane Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Spindle Assembly Late Endosome To Vacuole Transport Cytokinetic Process Endosome Transport Via Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Organization Membrane Fission Multivesicular Body Sorting Pathway Nuclear Membrane Organization Autophagosome Maturation Autophagosome Membrane Membrane Assembly Nuclear Pore Nucleus Organization Endosome Vesicle Fusion Organelle Membrane Fusion Regulation Of Organelle Assembly Endosomal Transport Membrane Coat Osteoblast Fate Commitment Plasma Membrane Organization Lysosomal Transport Cytosol Autophagy Organelle Fusion
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