IGFBP7 and SDC1

Number of citations of the paper that reports this interaction (PMID 14521955)
2

Data Source:
HPRD (in vivo)

		IGFBP7	SDC1
Gene Name		insulin-like growth factor binding protein 7	syndecan 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome	Cytoplasm Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Lysosomal Lumen Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Insulin-like Growth Factor Binding	Glycoprotein Binding Protein Binding Protein C-terminus Binding
	Biological Process	Regulation Of Cell Growth Cell Adhesion Embryo Implantation Negative Regulation Of Cell Proliferation Response To Heat Response To Retinoic Acid Cellular Response To Hormone Stimulus Inner Ear Development Regulation Of Steroid Biosynthetic Process Response To Cortisol	Retinoid Metabolic Process Ureteric Bud Development Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Inflammatory Response Phototransduction, Visible Light Pathogenesis Response To Toxic Substance Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Wound Healing Lipoprotein Metabolic Process Odontogenesis Response To Hydrogen Peroxide Small Molecule Metabolic Process Myoblast Development Response To Glucocorticoid Response To CAMP Response To Calcium Ion Striated Muscle Cell Development Sertoli Cell Development Canonical Wnt Signaling Pathway Positive Regulation Of Exosomal Secretion Positive Regulation Of Extracellular Vesicular Exosome Assembly
Pathways		Cellular Senescence Senescence-Associated Secretory Phenotype (SASP)	Lipoprotein metabolism MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Metabolism of lipids and lipoproteins Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chylomicron-mediated lipid transport Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Non-integrin membrane-ECM interactions Lipid digestion, mobilization, and transport Defective EXT1 causes exostoses 1, TRPS2 and CHDS Diseases associated with visual transduction MPS IV - Morquio syndrome A Syndecan interactions Visual phototransduction MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates HS-GAG biosynthesis HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS		Age-related macular degeneration ( 21909106)
Protein-Protein Interactions		11 interactors: CCL21 CCL5 CHMP3 CXCL10 IGF1 IGF2 INHBA INS RBBP8 SDC1 VEGFA	15 interactors: APP CASK CCL5 CD63 CTSG CXCL8 ELANE FGF2 HGF IGFBP7 LACRT MDK MMP14 PTN SDCBP
Entrez ID		3490	6382
HPRD ID		04183	01718
Ensembl ID		ENSG00000163453	ENSG00000115884
Uniprot IDs		Q16270	P18827
PDB IDs			4GVC 4GVD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transport Positive Regulation Of Protein Kinase B Signaling Regulation Of Protein Kinase B Signaling Regulation Of Protein Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Positive Regulation Of Organelle Organization Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Behavior Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Glycogen Biosynthetic Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Positive Regulation Of Macromolecule Biosynthetic Process Secretion By Cell Response To Stress Positive Regulation Of Leukocyte Migration Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of T Cell Migration Regulation Of Cellular Localization Regulation Of T Cell Migration Regulation Of Cell Migration Leukocyte Chemotaxis Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Chemotaxis Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Motility Secretion Regulation Of Leukocyte Migration Positive Regulation Of Cell Division Regulation Of Locomotion Cell Activation Positive Regulation Of Behavior Regulation Of Cellular Component Movement Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Chemotaxis	Cell Migration Locomotion Cell Motility Positive Regulation Of Cellular Metabolic Process Movement Of Cell Or Subcellular Component Response To External Stimulus Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Behavior Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Response To Lipid Regulation Of Phosphorylation Positive Regulation Of Phosphorylation Response To Stress Positive Chemotaxis Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Chemotaxis Interaction With Symbiont Regulation Of Growth Positive Regulation Of Cell Migration Regulation Of Protein Metabolic Process Regulation Of Chemotaxis Positive Regulation Of Cell Motility Secretion Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Locomotion Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Response To Stimulus Response To Organic Substance Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Defense Response Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Protein Metabolic Process Killing By Host Of Symbiont Cells Positive Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Platelet Degranulation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transferase Activity Positive Regulation Of Catalytic Activity Organ Development Regulation Of Body Fluid Levels
Tagcloud ?		achieve additive aza dc demethylating demethylation deoxycytidine difficult dual efficiently epigenetic exists ezh2 focusing gsk126 h3k27me3 limitation methylated methylation modification modifications overcome preferentially promising re sfrp1 trimethylation utilized xenograft	alpha3beta1 alpha6beta4 beta4 block c2 competes coupling depends egf engagement engaging extreme her1 integrin laminin ln332 matrix migration penetrating platform qeexyx recognize sdc4 shares spreading syndecan syndecans utilized
Tagcloud (Difference) ?		achieve additive aza dc demethylating demethylation deoxycytidine difficult dual efficiently epigenetic exists ezh2 focusing gsk126 h3k27me3 limitation methylated methylation modification modifications overcome preferentially promising re sfrp1 trimethylation xenograft	alpha3beta1 alpha6beta4 beta4 block c2 competes coupling depends egf engagement engaging extreme her1 integrin laminin ln332 matrix migration penetrating platform qeexyx recognize sdc4 shares spreading syndecan syndecans
Tagcloud (Intersection) ?		utilized