IGFBP7 and CCL5

Number of citations of the paper that reports this interaction (PubMedID 12847218)
0

Data Source:
HPRD (in vitro)

		IGFBP7	CCL5
Description		insulin like growth factor binding protein 7	C-C motif chemokine ligand 5
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Exosome	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Insulin-like Growth Factor Binding Growth Factor Binding Receptor Ligand Activity	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Protein Kinase Activity Cytokine Activity Protein Binding Chemokine Activity Phospholipase Activator Activity Receptor Signaling Protein Tyrosine Kinase Activator Activity CCR1 Chemokine Receptor Binding CCR4 Chemokine Receptor Binding CCR5 Chemokine Receptor Binding Chemoattractant Activity Chemokine Receptor Binding Identical Protein Binding Protein Homodimerization Activity Chemokine Receptor Antagonist Activity CCR Chemokine Receptor Binding
	Biological Process	Angiogenesis Regulation Of Cell Growth Cell Adhesion Signal Transduction Embryo Implantation Negative Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Response To Retinoic Acid Cellular Response To Hormone Stimulus Regulation Of Steroid Biosynthetic Process Response To Cortisol Cellular Response To Prostaglandin E Stimulus	Dendritic Cell Chemotaxis Monocyte Chemotaxis Regulation Of Chronic Inflammatory Response Calcium Ion Transport Intracellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Leukocyte Cell-cell Adhesion G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Virus Response To Toxic Substance Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of T Cell Chemotaxis Positive Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cell Migration Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of TOR Signaling Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Response To Cytokine Positive Regulation Of Homotypic Cell-cell Adhesion Response To Tumor Necrosis Factor Chemokine (C-C Motif) Ligand 5 Signaling Pathway Positive Regulation Of T Cell Proliferation Neutrophil Activation Host-mediated Suppression Of Viral Transcription Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Positive Regulation Of Innate Immune Response Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Positive Regulation Of Translational Initiation Eosinophil Chemotaxis Macrophage Chemotaxis Positive Regulation Of Smooth Muscle Cell Proliferation Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Insulin Secretion Regulation Of T Cell Activation Positive Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Calcium Ion Transport Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Negative Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of T Cell Apoptotic Process ERK1 And ERK2 Cascade Cellular Response To Type II Interferon Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Monocyte Chemotaxis Cell Surface Receptor Signaling Pathway Via STAT Cellular Response To Virus Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Receptor Signaling Pathway Via STAT Negative Regulation Of Macrophage Apoptotic Process Positive Regulation Of T Cell Migration Positive Regulation Of Natural Killer Cell Chemotaxis
Pathways		Senescence-Associated Secretory Phenotype (SASP) Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs		Insulin human	Heparin Disaccharide I-S Heparin Disaccharide Iii-S
Diseases
GWAS		Age-related macular degeneration ( 21909106) Alcohol consumption (max-drinks) ( 29460428) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) Brain volume in infants (grey matter) ( 28763065) Congenital heart disease (maternal effect) ( 28468790) Diastolic blood pressure ( 30224653) Heel bone mineral density ( 28869591) Hyperemesis gravidarum ( 29563502) Schizophrenia x sex interaction ( 34099189) Severity of nausea and vomiting of pregnancy ( 29563502)	Blood protein levels ( 30072576)
Interacting Genes		11 interacting genes: CCL21 CCL5 CHMP3 CXCL10 IGF1 IGF2 INHBA INS RBBP8 SDC1 VEGFA	55 interacting genes: ACKR1 ACKR2 ACKR4 APC BAG4 BCAR3 CCL11 CCL13 CCL16 CCL17 CCL2 CCL20 CCL21 CCL24 CCL25 CCL26 CCL27 CCL28 CCR1 CCR3 CCR4 CCR5 CHEK2 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL2 CXCL6 CXCL8 CXCL9 DPP4 EDC4 FZR1 GRB2 IGFBP7 KRAS PALB2 PF4 PHB1 PIGR PPBP PTPN1 RANGAP1 RELA SDC1 SDC4 SLC2A5 TGFB1 TRIP6 VCAN WT1 XCL1 XCL2
Entrez ID		3490	6352
HPRD ID		04183	01751
Ensembl ID		ENSG00000163453	ENSG00000271503
Uniprot IDs		Q16270	A0A494C1Q1 D0EI67 P13501
PDB IDs		8IVD	1B3A 1EQT 1HRJ 1RTN 1RTO 1U4L 1U4M 1U4P 1U4R 2L9H 2VXW 5CMD 5COY 5DNF 5L2U 5UIW 6AEZ 6C6D 6FGP 6LOG 6STK 7F1R 7O7F
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Transport Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Transport Insulin-like Growth Factor Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Positive Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Positive Regulation Of Glycogen Biosynthetic Process Cytokine Activity Granulocyte Chemotaxis Regulation Of T Cell Chemotaxis Extracellular Region Granulocyte Migration Positive Regulation Of Leukocyte Chemotaxis Insulin Receptor Binding Extracellular Space Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Cell Migration Regulation Of Secretion By Cell Hormone Activity Positive Regulation Of Cell Motility Regulation Of Immune System Process Positive Regulation Of Locomotion Regulation Of Glycogen Biosynthetic Process Regulation Of Secretion Receptor Ligand Activity Myeloid Leukocyte Migration Chemoattractant Activity Regulation Of Cellular Component Organization Regulation Of MAPK Cascade Leukocyte Chemotaxis Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of T Cell Migration Positive Regulation Of Chemotaxis Positive Regulation Of Leukocyte Migration Regulation Of Glycogen Metabolic Process Growth Factor Activity Regulation Of Cell Cycle Process Positive Regulation Of Lymphocyte Migration Positive Chemotaxis Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Mitotic Nuclear Division Regulation Of T Cell Migration Chemokine Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Epithelial Cell Proliferation Cell Chemotaxis Regulation Of Apoptotic Process	Chemokine Activity Cell Chemotaxis Chemotaxis Locomotion Chemokine-mediated Signaling Pathway Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Cell Migration Cytokine Activity Leukocyte Chemotaxis Cell Motility Inflammatory Response Humoral Immune Response Leukocyte Migration Granulocyte Chemotaxis Myeloid Leukocyte Migration Granulocyte Migration Cytokine-mediated Signaling Pathway Immune Response Killing Of Cells Of Another Organism Defense Response Cell Killing Defense Response To Symbiont Defense Response To Other Organism Immune System Process Response To Stress CXCR Chemokine Receptor Binding G Protein-coupled Receptor Signaling Pathway Signal Transduction Response To Other Organism CCR Chemokine Receptor Binding Response To External Biotic Stimulus Extracellular Space Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Migration Eosinophil Chemotaxis Mononuclear Cell Migration Extracellular Region Positive Regulation Of Locomotion Eosinophil Migration Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Leukocyte Migration Neutrophil Chemotaxis Chemokine Receptor Binding C-C Chemokine Binding Neutrophil Migration Positive Regulation Of Leukocyte Migration
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