TRIP13 and DCTN3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TRIP13	DCTN3
Description		thyroid hormone receptor interactor 13	dynactin subunit 3
Image			No pdb structure
GO Annotations	Cellular Component	Male Germ Cell Nucleus Nucleus Chromosome	Chromosome, Centromeric Region Kinetochore Chromosome Nucleolus Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Dynactin Complex Microtubule Associated Complex Midbody Cleavage Furrow Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Transcription Coregulator Activity Protein Binding ATP Binding ATP Hydrolysis Activity Identical Protein Binding	Structural Molecule Activity Protein Binding
	Biological Process	Oocyte Maturation Double-strand Break Repair Transcription By RNA Polymerase II Mitotic Spindle Assembly Checkpoint Signaling Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiosis I Female Meiosis I Spermatogenesis Spermatid Development Cell Differentiation Oogenesis Meiotic Cell Cycle Meiotic Recombination Checkpoint Signaling	Mitotic Cell Cycle Microtubule-based Process Cell Division Cytoskeleton-dependent Cytokinesis
Pathways			MHC class II antigen presentation Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic AURKA Activation by TPX2
Drugs
Diseases
GWAS		Pancreatic cancer ( 25086665)	Appendicular lean mass ( 33097823)
Interacting Genes		113 interacting genes: ACTMAP ADAM15 AMDHD2 ANKRD10 ARL11 ARSA ASB13 BKGD BUB1B C4orf33 CARD14 CD99 CDC20 CDIN1 CEP170B CFP CLIP4 COMT CRMP1 CRYBA2 CYB5R2 DCTN3 DDAH2 DIP2A DPYSL4 DTX2 EEF2KMT FBLN5 FBXO8 FILNC1 FNDC3B GALT GLYCTK GPRIN2 GPSM1 HDHD3 IGFN1 IL2RB INCA1 INTS11 KRTAP12-1 KRTAP12-2 KRTAP12-4 KRTAP26-1 KRTAP3-2 KRTAP6-1 KRTAP6-2 KYAT1 LASP1 LNX1 LOXL4 LRR1 LRRC61 M1AP MAD2L1 MAD2L1BP MBLAC1 MEAK7 METTL15 MGAT5B MORN3 MPPED2 MVP MYEOV NIF3L1 NME4 NTAQ1 PARP11 PAX9 PBLD PCMTD2 PCSK5 PELI1 PLAC8 PLK3 PLSCR3 PLSCR4 POLR2L PPP2CA PRKAA2 PRKN PRR13 PSMB8 QARS1 RBPMS RHOXF2 RNF4 SCP2 SDCBP SEC24A SELENBP1 SEMA3B SEMA4G SHARPIN SIGLEC5 SMUG1 SPMIP9 SPRYD7 SSC4D STAMBP STAMBPL1 SUMO2 TENT5B THRB TINAGL1 TNRC6A TPT1 UBE2I VDR VENTX ZMYM5 ZNF34 ZNF655	11 interacting genes: ATXN1 DCTN1 GSK3B KRT34 NUP54 PBX2 PITX1 TRIM55 TRIP13 USHBP1 VPS37C
Entrez ID		9319	11258
HPRD ID		05145	06303
Ensembl ID		ENSG00000071539	ENSG00000137100
Uniprot IDs		Q15645	O75935 X6RLR1
PDB IDs		5VQ9 5VQA 5WC2 6F0X 6LK0 7L9P
Enriched GO Terms of Interacting Partners?		Protein Binding Mitotic Checkpoint Complex Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Protein K6-linked Ubiquitination Intermediate Filament	Regulation Of Dendritic Cell Dendrite Assembly CCR7 Chemokine Receptor Binding Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Establishment Of T Cell Polarity Negative Regulation Of Dendritic Cell Apoptotic Process Chemokine Receptor Binding Establishment Of Cell Polarity Immunological Synapse Formation Dendritic Cell Chemotaxis Mononuclear Cell Migration Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Glycoprotein Biosynthetic Process Cellular Response To Prostaglandin E Stimulus Eosinophil Chemotaxis Positive Regulation Of Glycoprotein Metabolic Process Eosinophil Migration Myeloid Leukocyte Migration Regulation Of Antigen Processing And Presentation Dendritic Cell Migration Positive Regulation Of Neutrophil Chemotaxis Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Cell Maturation Positive Regulation Of Granulocyte Chemotaxis CCR Chemokine Receptor Binding Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Neutrophil Migration Regulation Of Neutrophil Chemotaxis Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cellular Component Biogenesis Neuron Projection Organization Tau Protein Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Developmental Maturation Regulation Of Neutrophil Migration T Cell Costimulation Chemokine Activity Leukocyte Migration Regulation Of Cell Projection Assembly Regulation Of Granulocyte Chemotaxis Regulation Of Microtubule Anchoring At Centrosome Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Dendritic Cell Dendrite Assembly Dendritic Cell Dendrite Assembly Negative Regulation Of Dendritic Cell Dendrite Assembly Negative Regulation Of Leukocyte Apoptotic Process Release Of Sequestered Calcium Ion Into Cytosol Cell-cell Recognition
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