TRIP13 and AMDHD2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		TRIP13	AMDHD2
Description		thyroid hormone receptor interactor 13	amidohydrolase domain containing 2
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GO Annotations	Cellular Component	Male Germ Cell Nucleus Nucleus Chromosome	Nucleus Cytosol
	Molecular Function	Nucleotide Binding Transcription Coregulator Activity Protein Binding ATP Binding ATP Hydrolysis Activity Identical Protein Binding	Protein Binding N-acetylglucosamine-6-phosphate Deacetylase Activity Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Metal Ion Binding N-acetylgalactosamine-6-phosphate Deacetylase Activity
	Biological Process	Oocyte Maturation Double-strand Break Repair Transcription By RNA Polymerase II Mitotic Spindle Assembly Checkpoint Signaling Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiosis I Female Meiosis I Spermatogenesis Spermatid Development Cell Differentiation Oogenesis Meiotic Cell Cycle Meiotic Recombination Checkpoint Signaling	N-acetylglucosamine Metabolic Process N-acetylglucosamine Catabolic Process UDP-N-acetylglucosamine Biosynthetic Process N-acetylneuraminate Catabolic Process Negative Regulation Of UDP-N-acetylglucosamine Biosynthetic Process
Pathways			Synthesis of UDP-N-acetyl-glucosamine
Drugs
Diseases
GWAS		Pancreatic cancer ( 25086665)
Interacting Genes		113 interacting genes: ACTMAP ADAM15 AMDHD2 ANKRD10 ARL11 ARSA ASB13 BKGD BUB1B C4orf33 CARD14 CD99 CDC20 CDIN1 CEP170B CFP CLIP4 COMT CRMP1 CRYBA2 CYB5R2 DCTN3 DDAH2 DIP2A DPYSL4 DTX2 EEF2KMT FBLN5 FBXO8 FILNC1 FNDC3B GALT GLYCTK GPRIN2 GPSM1 HDHD3 IGFN1 IL2RB INCA1 INTS11 KRTAP12-1 KRTAP12-2 KRTAP12-4 KRTAP26-1 KRTAP3-2 KRTAP6-1 KRTAP6-2 KYAT1 LASP1 LNX1 LOXL4 LRR1 LRRC61 M1AP MAD2L1 MAD2L1BP MBLAC1 MEAK7 METTL15 MGAT5B MORN3 MPPED2 MVP MYEOV NIF3L1 NME4 NTAQ1 PARP11 PAX9 PBLD PCMTD2 PCSK5 PELI1 PLAC8 PLK3 PLSCR3 PLSCR4 POLR2L PPP2CA PRKAA2 PRKN PRR13 PSMB8 QARS1 RBPMS RHOXF2 RNF4 SCP2 SDCBP SEC24A SELENBP1 SEMA3B SEMA4G SHARPIN SIGLEC5 SMUG1 SPMIP9 SPRYD7 SSC4D STAMBP STAMBPL1 SUMO2 TENT5B THRB TINAGL1 TNRC6A TPT1 UBE2I VDR VENTX ZMYM5 ZNF34 ZNF655	1 interacting genes: TRIP13
Entrez ID		9319	51005
HPRD ID		05145	13034
Ensembl ID		ENSG00000071539	ENSG00000162066
Uniprot IDs		Q15645	A0A3B3IU33 Q9Y303
PDB IDs		5VQ9 5VQA 5WC2 6F0X 6LK0 7L9P	7NUT 7NUU
Enriched GO Terms of Interacting Partners?		Protein Binding Mitotic Checkpoint Complex Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Protein K6-linked Ubiquitination Intermediate Filament	Oocyte Maturation Synaptonemal Complex Assembly Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Meiotic Nuclear Division Meiosis I Synaptonemal Complex Organization Female Meiosis I Male Meiosis I Regulation Of Meiotic Nuclear Division Reciprocal Meiotic Recombination Homologous Recombination Meiotic Recombination Checkpoint Signaling Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Meiotic Cell Cycle Meiotic Cell Cycle Checkpoint Signaling Female Meiotic Nuclear Division Oogenesis Male Meiotic Nuclear Division Male Germ Cell Nucleus Chromosome Organization Involved In Meiotic Cell Cycle Regulation Of Mitotic Sister Chromatid Separation Female Gamete Generation Regulation Of Meiotic Cell Cycle Negative Regulation Of Reproductive Process Meiosis I Cell Cycle Process Meiotic Nuclear Division Regulation Of Chromosome Separation Negative Regulation Of Chromosome Organization Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Spermatid Development Regulation Of Sister Chromatid Segregation Meiotic Cell Cycle Regulation Of Mitotic Nuclear Division Transcription Coregulator Activity Regulation Of Chromosome Segregation Regulation Of Nuclear Division Cell Maturation Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Reproductive Process Germ Cell Development Developmental Maturation Negative Regulation Of Mitotic Cell Cycle Double-strand Break Repair Negative Regulation Of Cell Cycle Phase Transition DNA Recombination Regulation Of Chromosome Organization Negative Regulation Of Cell Cycle Process Transcription By RNA Polymerase II
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