SNTG2 and VANGL2

Number of citations of the paper that reports this interaction (PubMedID 23722234)
86

Data Source:
BioGRID (two hybrid)

		SNTG2	VANGL2
Description		syntrophin gamma 2	VANGL planar cell polarity protein 2
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytoskeleton Plasma Membrane Dystrophin-associated Glycoprotein Complex Syntrophin Complex Membrane Sarcolemma	Stress Fiber Plasma Membrane Cell-cell Junction Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane COPII-coated ER To Golgi Transport Vesicle Cell Pole Cell Periphery Apical Cytoplasm Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Actin Binding Structural Molecule Activity Protein Binding PDZ Domain Binding Neuroligin Family Protein Binding	Protein Binding
	Biological Process	Central Nervous System Development	Establishment Of Planar Polarity Neural Tube Closure Hair Follicle Development Heart Looping Membranous Septum Morphogenesis Muscular Septum Morphogenesis Rho Protein Signal Transduction Anterior/posterior Pattern Specification Heparan Sulfate Proteoglycan Biosynthetic Process Convergent Extension Involved In Neural Plate Elongation Regulation Of Wnt Signaling Pathway Glomerulus Development Regulation Of Actin Cytoskeleton Organization Somatic Stem Cell Population Maintenance Non-canonical Wnt Signaling Pathway Cell Migration Involved In Kidney Development Post-anal Tail Morphogenesis Dopaminergic Neuron Axon Guidance Serotonergic Neuron Axon Guidance Wound Healing Apical Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Somatic Stem Cell Division Establishment Of Body Hair Planar Orientation Digestive Tract Morphogenesis Convergent Extension Involved In Axis Elongation Convergent Extension Involved In Organogenesis Wnt Signaling Pathway, Planar Cell Polarity Pathway Inner Ear Receptor Cell Development Inner Ear Receptor Cell Stereocilium Organization Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Lateral Sprouting Involved In Lung Morphogenesis Kidney Morphogenesis Cochlea Development Cochlea Morphogenesis Regulation Of Establishment Of Planar Polarity Establishment Of Planar Polarity Involved In Neural Tube Closure Non-motile Cilium Assembly Regulation Of Synapse Pruning
Pathways		Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	PCP/CE pathway Asymmetric localization of PCP proteins RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs
Diseases
GWAS		Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Calcific aortic valve stenosis ( 32141789) Familial squamous cell lung carcinoma ( 29924316) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hypothyroidism ( 27182965) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Refractive error ( 32231278) Thrombin-activatable fibrinolysis inhibitor levels ( 29378355)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive performance ( 19734545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Left-handedness ( 32989287) Multiple sclerosis ( 24076602 31604244) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systemic lupus erythematosus ( 28714469)
Interacting Genes		13 interacting genes: ADGRB1 BET1 DMD DTNA DTNB HACE1 MIPOL1 MPP3 PALS1 RPS6KA1 SCN5A VANGL2 VCPIP1	27 interacting genes: AP1M1 ARFRP1 ARHGEF12 DLG2 DLG4 DVL1 GIPC1 KBTBD7 LIN7A LRRC7 MAGI2 MAGI3 MAST1 MAST2 MPDZ PDZRN3 PTPN13 PTPN4 SCRIB SNTA1 SNTB1 SNTG1 SNTG2 SNX27 SQSTM1 SYNJ2BP VCP
Entrez ID		54221	57216
HPRD ID		16374	02758
Ensembl ID		ENSG00000172554	ENSG00000162738
Uniprot IDs		Q9NY99	A8K4L6 Q9ULK5
PDB IDs		7QQL	6XA6 6XA7 6XA8 7R2M 7R2T 9JK7 9JKA
Enriched GO Terms of Interacting Partners?		PDZ Domain Binding Striated Muscle Contraction Nitric-oxide Synthase Binding Lateral Plasma Membrane Membrane Organization Sarcolemma Cell Communication Golgi Organization Synaptic Signaling Anchoring Junction Membrane Fusion Neuron Development Cell-cell Junction Synapse Regulation Of Sodium Ion Transmembrane Transport Muscle Contraction Cardiac Muscle Cell Action Potential Cardiac Muscle Contraction Voltage-gated Sodium Channel Activity Involved In AV Node Cell Action Potential Voltage-gated Sodium Channel Activity Involved In Purkinje Myocyte Action Potential Voltage-gated Sodium Channel Activity Involved In Bundle Of His Cell Action Potential Voltage-gated Sodium Channel Activity Involved In SA Node Cell Action Potential Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization To Myelin Sheath Abaxonal Region Muscle System Process Cell-cell Signaling Signaling Regulation Of Sodium Ion Transport Bundle Of His Cell Action Potential Membrane Depolarization During Bundle Of His Cell Action Potential Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Establishment Of Planar Polarity Involved In Neural Tube Closure Cell Pole Cell Migration Involved In Kidney Development Lateral Sprouting Involved In Lung Morphogenesis Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Establishment Or Maintenance Of Polarity Of Embryonic Epithelium Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Regulation Of Cardiac Muscle Contraction Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential Membrane Depolarization During Purkinje Myocyte Cell Action Potential Serotonergic Neuron Axon Guidance Convergent Extension Involved In Neural Plate Elongation Dopaminergic Neuron Axon Guidance Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Apical Plasma Membrane Regulation Of Striated Muscle Contraction Regulation Of Heart Rate Syntrophin Complex	Receptor Clustering Synapse Dystrophin-associated Glycoprotein Complex Syntrophin Complex Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Postsynaptic Density Establishment Of Protein Localization Protein Localization To Membrane Localization Within Membrane Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Localization To Synapse Intracellular Protein Transport Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Synapse Endosomal Transport Establishment Or Maintenance Of Cell Polarity Intracellular Protein Localization Vesicle-mediated Transport Neuromuscular Junction Beta-1 Adrenergic Receptor Binding PDZ Domain Binding Cellular Localization Protein Localization To Cell Junction Neuron Projection Ionotropic Glutamate Receptor Binding Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Cytoplasm Glutamatergic Synapse Neuroligin Family Protein Binding Protein Transport Anchoring Junction Bicellular Tight Junction Vesicle-mediated Transport To The Plasma Membrane Protein Kinase Binding Establishment Of Localization In Cell Positive Regulation Of Neuron Projection Arborization GMP Kinase Activity Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Establishment Of Protein Localization To Plasma Membrane Regulation Of Synapse Organization Ubiquitin-modified Protein Reader Activity Neurotransmitter Receptor Transport To Postsynaptic Membrane GDP Metabolic Process Establishment Of Protein Localization To Postsynaptic Membrane Neurotransmitter Receptor Transport To Plasma Membrane Juxtaparanode Region Of Axon Protein-containing Complex Localization Structural Molecule Activity
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