COL4A3 and MFAP2

Number of citations of the paper that reports this interaction (PMID 9278443)
12

Data Source:
HPRD (in vitro)

		COL4A3	MFAP2
Gene Name		collagen, type IV, alpha 3 (Goodpasture antigen)	microfibrillar-associated protein 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Lumen	Microfibril Extracellular Region
	Molecular Function	Integrin Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Metalloendopeptidase Inhibitor Activity	Fibronectin Binding Fibrinogen Binding
	Biological Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Adhesion Cell Surface Receptor Signaling Pathway Axon Guidance Sensory Perception Of Sound Blood Circulation Cell Proliferation Negative Regulation Of Cell Proliferation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Angiogenesis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Glomerular Basement Membrane Development Endothelial Cell Apoptotic Process	Extracellular Matrix Organization Platelet Formation
Pathways		Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Laminin interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth	Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS		Corneal structure ( 23291589) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000)	Height ( 20881960 23563607) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291)
Protein-Protein Interactions		17 interactors: ANTXR2 APP CAMK2B CD93 COL4A3BP DCN FBLN2 FN1 HABP2 MATN2 MFAP2 MMP9 OSM SAA1 SERPINE2 TGFBI USH2A	5 interactors: BGN COL4A3 ELN FBN1 FBN2
Entrez ID		1285	4237
HPRD ID		00354	01137
Ensembl ID		ENSG00000169031	ENSG00000117122
Uniprot IDs		Q01955	P55001
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization System Development Immune System Process Response To Wounding Multicellular Organismal Development Anatomical Structure Development Anatomical Structure Morphogenesis Extracellular Matrix Disassembly Developmental Process Wound Healing Generation Of Neurons Cell Morphogenesis Nervous System Development Neurogenesis Cell Activation Cell Morphogenesis Involved In Differentiation Blood Coagulation Cell Differentiation Reproductive Process Hemostasis Response To Stress Platelet Activation Endodermal Cell Differentiation Acute-phase Response Regulation Of Meiosis Peptide Cross-linking Organ Development Leukocyte Migration Mating Regulation Of Body Fluid Levels Regulation Of Meiotic Cell Cycle Chemotaxis Endoderm Formation Response To Abiotic Stimulus Regulation Of Growth Seminal Vesicle Epithelium Development Dendrite Regeneration Inhibitory G-protein Coupled Receptor Phosphorylation Regulation Of Cell Adhesion Tissue Development Neurological System Process Response To External Stimulus Cell Adhesion Platelet Degranulation Regulation Of Neurogenesis Acute Inflammatory Response Locomotion Neuromuscular Process Controlling Balance Synaptic Growth At Neuromuscular Junction	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Sequestering Of TGFbeta In Extracellular Matrix Sequestering Of Extracellular Ligand From Receptor Extracellular Negative Regulation Of Signal Transduction Blood Vessel Remodeling Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Tissue Remodeling Maintenance Of Protein Location Regulation Of Cellular Response To Growth Factor Stimulus Endothelial Cell Apoptotic Process Sequestering Of BMP In Extracellular Matrix Organ Development Kidney Development Blood Circulation Renal System Development Dermatan Sulfate Biosynthetic Process Bone Trabecula Formation Urogenital System Development Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Stress Fiber Assembly Glomerular Basement Membrane Development Bone Trabecula Morphogenesis System Development Chondroitin Sulfate Biosynthetic Process Skeletal System Development Chondroitin Sulfate Proteoglycan Biosynthetic Process Multicellular Organismal Development Anatomical Structure Development Positive Regulation Of Bone Mineralization Cell Proliferation Anatomical Structure Morphogenesis Positive Regulation Of Biomineral Tissue Development Negative Regulation Of BMP Signaling Pathway Peptide Cross-linking Trabecula Morphogenesis Developmental Process Respiratory Gaseous Exchange Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Chondroitin Sulfate Metabolic Process Glomerulus Development Collagen Catabolic Process
Tagcloud ?		alport amplified aras ascending audiological audiometric august autosomal certainly curves descending drop eighty exons fibroblast flat groove hearing impairment inheritance moderate oae recessive sensorineural sequenced sixteen wherein xlas	capturing clu elastic encompassing etiopathogenesis europeans extraocular fbn1 fibrillar genotyped german glaucoma haplotypes intron italian likewise ltbp2 microfibrillopathy nominally nongenetic pex pexg pseudoexfoliation replicate rs2279590 snp snps tgm2 unrelated
Tagcloud (Difference) ?		alport amplified aras ascending audiological audiometric august autosomal certainly curves descending drop eighty exons fibroblast flat groove hearing impairment inheritance moderate oae recessive sensorineural sequenced sixteen wherein xlas	capturing clu elastic encompassing etiopathogenesis europeans extraocular fbn1 fibrillar genotyped german glaucoma haplotypes intron italian likewise ltbp2 microfibrillopathy nominally nongenetic pex pexg pseudoexfoliation replicate rs2279590 snp snps tgm2 unrelated
Tagcloud (Intersection) ?