COL4A3 and USH2A

Number of citations of the paper that reports this interaction (PMID 14676276)
9

Data Source:
HPRD (in vivo)

		COL4A3	USH2A
Gene Name		collagen, type IV, alpha 3 (Goodpasture antigen)	Usher syndrome 2A (autosomal recessive, mild)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Lumen	Photoreceptor Inner Segment Stereocilia Ankle Link Complex Basement Membrane Cytoplasm Integral Component Of Membrane Apical Plasma Membrane Photoreceptor Connecting Cilium Stereocilium Bundle Stereocilium Membrane Periciliary Membrane Compartment
	Molecular Function	Integrin Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Metalloendopeptidase Inhibitor Activity	Protein Binding Collagen Binding Myosin Binding
	Biological Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Adhesion Cell Surface Receptor Signaling Pathway Axon Guidance Sensory Perception Of Sound Blood Circulation Cell Proliferation Negative Regulation Of Cell Proliferation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Angiogenesis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Glomerular Basement Membrane Development Endothelial Cell Apoptotic Process	Visual Perception Sensory Perception Of Sound Hair Cell Differentiation Photoreceptor Cell Maintenance Maintenance Of Organ Identity Response To Stimulus Sensory Perception Of Light Stimulus Inner Ear Receptor Cell Differentiation
Pathways		Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Laminin interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS		Corneal structure ( 23291589) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000)
Protein-Protein Interactions		17 interactors: ANTXR2 APP CAMK2B CD93 COL4A3BP DCN FBLN2 FN1 HABP2 MATN2 MFAP2 MMP9 OSM SAA1 SERPINE2 TGFBI USH2A	3 interactors: BRCA1 COL4A3 KRT18
Entrez ID		1285	7399
HPRD ID		00354	09759
Ensembl ID		ENSG00000169031	ENSG00000042781
Uniprot IDs		Q01955	O75445
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization System Development Immune System Process Response To Wounding Multicellular Organismal Development Anatomical Structure Development Anatomical Structure Morphogenesis Extracellular Matrix Disassembly Developmental Process Wound Healing Generation Of Neurons Cell Morphogenesis Nervous System Development Neurogenesis Cell Activation Cell Morphogenesis Involved In Differentiation Blood Coagulation Cell Differentiation Reproductive Process Hemostasis Response To Stress Platelet Activation Endodermal Cell Differentiation Acute-phase Response Regulation Of Meiosis Peptide Cross-linking Organ Development Leukocyte Migration Mating Regulation Of Body Fluid Levels Regulation Of Meiotic Cell Cycle Chemotaxis Endoderm Formation Response To Abiotic Stimulus Regulation Of Growth Seminal Vesicle Epithelium Development Dendrite Regeneration Inhibitory G-protein Coupled Receptor Phosphorylation Regulation Of Cell Adhesion Tissue Development Neurological System Process Response To External Stimulus Cell Adhesion Platelet Degranulation Regulation Of Neurogenesis Acute Inflammatory Response Locomotion Neuromuscular Process Controlling Balance Synaptic Growth At Neuromuscular Junction	Cellular Response To Tumor Necrosis Factor Apoptotic Process Programmed Cell Death Response To Tumor Necrosis Factor Cell Death Death Positive Regulation Of Histone H4-K20 Methylation Golgi To Plasma Membrane CFTR Protein Transport Positive Regulation Of Histone H4-K16 Acetylation Positive Regulation Of Histone H3-K9 Acetylation Regulation Of Apoptotic Process Regulation Of Angiogenesis Regulation Of Cell Death Endothelial Cell Apoptotic Process Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Cellular Response To Indole-3-methanol Apoptotic Signaling Pathway Negative Regulation Of Centriole Replication Dosage Compensation By Inactivation Of X Chromosome Protein K6-linked Ubiquitination Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Dosage Compensation Regulation Of Histone H3-K9 Acetylation Regulation Of Centriole Replication Positive Regulation Of Histone H3-K4 Methylation Regulation Of Histone H4 Acetylation Negative Regulation Of Fatty Acid Biosynthetic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Cellular Response To Cytokine Stimulus Negative Regulation Of Histone Methylation Negative Regulation Of Centrosome Duplication Glomerular Basement Membrane Development Regulation Of DNA Methylation Negative Regulation Of Histone Acetylation Positive Regulation Of Histone Acetylation Negative Regulation Of Peptidyl-lysine Acetylation Regulation Of Histone H3-K4 Methylation Hepatocyte Apoptotic Process Negative Regulation Of Protein Acetylation Positive Regulation Of Peptidyl-lysine Acetylation Response To Cytokine Postreplication Repair Positive Regulation Of Protein Acetylation Regulation Of Transcription From RNA Polymerase III Promoter Golgi To Plasma Membrane Protein Transport Negative Regulation Of Fatty Acid Metabolic Process Regulation Of Gene Expression By Genetic Imprinting
Tagcloud ?		alport amplified aras ascending audiological audiometric august autosomal certainly curves descending drop eighty exons fibroblast flat groove hearing impairment inheritance moderate oae recessive sensorineural sequenced sixteen wherein xlas	aggregated anaplastic atc braf cdkn1b cdkn2c ctnnb1 eif1ax exclusive exome harbored hypermutator landscape mismatch mlh mlh1 mlh3 msh5 msh6 mutational mutually nf1 nf2 nras ontology pik3ca ret unresponsive v600e
Tagcloud (Difference) ?		alport amplified aras ascending audiological audiometric august autosomal certainly curves descending drop eighty exons fibroblast flat groove hearing impairment inheritance moderate oae recessive sensorineural sequenced sixteen wherein xlas	aggregated anaplastic atc braf cdkn1b cdkn2c ctnnb1 eif1ax exclusive exome harbored hypermutator landscape mismatch mlh mlh1 mlh3 msh5 msh6 mutational mutually nf1 nf2 nras ontology pik3ca ret unresponsive v600e
Tagcloud (Intersection) ?