COL4A3 and ANTXR2

Number of citations of the paper that reports this interaction (PubMedID 11683410)
0

Data Source:
HPRD (in vivo)

		COL4A3	ANTXR2
Description		collagen type IV alpha 3 chain	ANTXR cell adhesion molecule 2
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Endoplasmic Reticulum Lumen Extracellular Matrix	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane
	Molecular Function	Integrin Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Metalloendopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Conferring Tensile Strength	Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity Metal Ion Binding
	Biological Process	Cell Adhesion Cell Surface Receptor Signaling Pathway Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Negative Regulation Of Angiogenesis Glomerular Basement Membrane Development Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Endothelial Cell Apoptotic Process Negative Regulation Of Vascular Endothelial Cell Proliferation	Single Fertilization Collagen Fibril Organization Uterus Development
Pathways		Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization Attachment of bacteria to epithelial cells
Drugs			MDX-1303
Diseases		Benign familial hematuria; Thin basement membrane nephropathy Alport syndrome	Infantile systemic hyalinosis and juvenile hyaline fibromatosis
GWAS		Advanced age-related macular degeneration ( 26691988) Central corneal thickness ( 29760442 31798171 32528159) Corneal structure ( 23291589) Diabetic nephropathy in type 1 diabetes ( 31537649) Hematuria ( 30476138) Hematuria (moderate to severe) ( 30476138) Intraocular pressure ( 29235454) Kidney disease (end stage renal disease or albuminuria) in type 1 diabetes ( 31537649) Kidney disease (reduced eGFR and albuminuria or end stage renal disease) in type 1 diabetes ( 31537649) Macroalbuminuria in type 1 diabetes ( 31537649) Macular thickness ( 30535121) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Refractive error ( 32231278) Resting heart rate ( 27798624)	Adult body size ( 32376654) Ankylosing spondylitis ( 21743469 20062062) Bipolar disorder (inflammation and infection response interaction) ( 25781172) Carotid plaque burden ( 28282560) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Essential hypertension (time to event) ( 32589924) Hand grip strength ( 29691431) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Myopia ( 27182965) Neutrophil percentage of white cells ( 27863252 32888494) Refractive error ( 32231278) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Spherical equivalent or myopia (age of diagnosis) ( 29808027) White blood cell count ( 32888494)
Interacting Genes		17 interacting genes: ANTXR2 APP CAMK2B CD93 CERT1 DCN FBLN2 FN1 HABP2 MATN2 MFAP2 MMP9 OSM SAA1 SERPINE2 TGFBI USH2A	9 interacting genes: CFTR COL4A2 COL4A3 COL4A4 COL4A5 LAMB1 LAMC1 LRP6 SMAD2
Entrez ID		1285	118429
HPRD ID		00354	07452
Ensembl ID		ENSG00000169031	ENSG00000163297
Uniprot IDs		Q01955	A4FUA5 J3KPY9 P58335 Q32Q26
PDB IDs		5NB0 6WKU	1SHT 1SHU 1T6B 1TZN 7N1O 8FT6 8FT8 8FZ4 8FZU 8FZV 9DOC
Enriched GO Terms of Interacting Partners?		Extracellular Region Extracellular Matrix Extracellular Matrix Structural Constituent Collagen Binding Glycosaminoglycan Binding Basement Membrane Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Heparin Binding Peptidase Activator Activity Extracellular Space Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Developmental Process Platelet Alpha Granule High-density Lipoprotein Particle Regulation Of Cell Migration Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Cell Motility Integrin Binding Regulation Of Locomotion Positive Regulation Of Synaptic Transmission Regulation Of Cell Differentiation Amyloid-beta Complex Signaling Receptor Binding Growth Cone Lamellipodium Regulation Of Monoatomic Ion Transport Regulation Of Response To Calcium Ion Regulation Of Synaptic Plasticity Positive Regulation Of Cell Communication Amylin Binding Positive Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Multicellular Organismal Process Regulation Of Inflammatory Response Regulation Of Multicellular Organismal Process Dendrite Development Identical Protein Binding Regulation Of Cell Adhesion Acute-phase Response Endodermal Cell Differentiation Oncostatin-M Receptor Binding Cerebellar Granular Layer Morphogenesis Mating Plug Formation Seminal Vesicle Epithelium Development Intermembrane Sphingolipid Transfer Response To Wounding Regulation Of Developmental Process Cell Adhesion	Basement Membrane Extracellular Matrix Structural Constituent Collagen Type IV Trimer Extracellular Matrix Extracellular Matrix Structural Constituent Conferring Tensile Strength Endoplasmic Reticulum Lumen Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Collagen Trimer Laminin-1 Complex Laminin-10 Complex Regulation Of Basement Membrane Organization Protein Complex Involved In Cell-matrix Adhesion Extracellular Structure Organization Extracellular Matrix Organization Glomerular Basement Membrane Development Positive Regulation Of Integrin-mediated Signaling Pathway Regulation Of Integrin-mediated Signaling Pathway Response To Cholesterol Developmental Process Extracellular Region Endoderm Development Endodermal Cell Differentiation Animal Organ Morphogenesis Substrate Adhesion-dependent Cell Spreading Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Response To Alcohol Laminin-8 Complex Neuronal-glial Interaction Involved In Cerebral Cortex Radial Glia Guided Migration CAAX-box Protein Maturation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Extracellular Matrix Organization Response To Transforming Growth Factor Beta Positive Regulation Of Anion Channel Activity Laminin-2 Complex Positive Regulation Of Muscle Cell Differentiation Roof Of Mouth Development Homomeric SMAD Protein Complex Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Odontogenesis Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Monoatomic Anion Transport Regulation Of Epithelial Cell Proliferation Laminin-11 Complex Zygotic Specification Of Dorsal/ventral Axis Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis
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