AHNAK and KLHL40

Number of citations of the paper that reports this interaction (PubMedID 24960163)
62

Data Source:
BioGRID (two hybrid)

		AHNAK	KLHL40
Description		AHNAK nucleoprotein	kelch like family member 40
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GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosomal Membrane Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane T-tubule Vesicle Sarcolemma Costamere Cell-cell Contact Zone Membrane Raft Extracellular Exosome Plasma Membrane Protein Complex	Cytoplasm Cul3-RING Ubiquitin Ligase Complex A Band I Band
	Molecular Function	RNA Binding Protein Binding Identical Protein Binding S100 Protein Binding Cadherin Binding Structural Molecule Activity Conferring Elasticity	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Regulation Of RNA Splicing Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Plasma Membrane Repair	Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Skeletal Muscle Fiber Development Skeletal Muscle Fiber Differentiation
Pathways
Drugs
Diseases
GWAS		A body shape index ( 34021172) Alanine aminotransferase levels ( 33547301) Alzheimer's disease (late onset) ( 28714976) Blond vs. brown/black hair color ( 30531825) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Cutaneous melanoma or hair colour ( 32341527) Gamma glutamyl transferase levels ( 33339817 29403010) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 28869591 30598549) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung function (FEV1) ( 28166213) Monocyte percentage of white cells ( 32888494) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Serum alkaline phosphatase levels ( 31666285) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		13 interacting genes: AKT1 CDKN2A EGFR FNDC3B KLHL40 MEOX2 NOL9 POT1 S100B SUMO2 USP7 WEE2-AS1 XRCC4	13 interacting genes: AHNAK CC2D1B FBXL9P FSD2 LMOD3 REL SAR1A SAXO1 SPMIP4 TASOR2 VDAC1 ZBED1 ZNF451
Entrez ID		79026	131377
HPRD ID		14684	11058
Ensembl ID		ENSG00000124942	ENSG00000157119
Uniprot IDs		B4DTV0 Q09666 Q9BVU3	A8K5H9 Q2TBA0
PDB IDs		4DRW 4FTG 4HRG	4ASC
Enriched GO Terms of Interacting Partners?		Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Regulation Of Proteolysis Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Response To UV-A Negative Regulation Of Post-translational Protein Modification Negative Regulation Of Protein Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Signal Transduction By P53 Class Mediator SUMO Transferase Activity Negative Regulation Of Protein Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Modification Process Regulation Of Peptidyl-serine Phosphorylation Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Proteolysis Regulation Of DNA Metabolic Process Regulation Of Cellular Localization Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Protein Ubiquitination Positive Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Myelination Regulation Of Cellular Response To Stress Regulation Of TRNA Methylation Response To Epidermal Growth Factor Ligase Inhibitor Activity Protein Sumoylation Multivesicular Body, Internal Vesicle Lumen FHA Domain Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Positive Regulation Of Catabolic Process Regulation Of Post-translational Protein Modification Nucleoplasm Positive Regulation Of Cell Cycle G1/S Phase Transition	SUMO Ligase Activity
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