BDNF and NTF3

Number of citations of the paper that reports this interaction (PMID 7703225)
18

Data Source:
HPRD (in vitro)

		BDNF	NTF3
Gene Name		brain-derived neurotrophic factor	neurotrophin 3
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Synaptic Vesicle Cytoplasmic Membrane-bounded Vesicle Mitochondrial Crista Dendrite Terminal Bouton Perikaryon Perinuclear Region Of Cytoplasm	Extracellular Region Cytoplasmic Membrane-bounded Vesicle
	Molecular Function	Neurotrophin TRKB Receptor Binding Growth Factor Activity	Receptor Binding Neurotrophin P75 Receptor Binding Growth Factor Activity Chemoattractant Activity Nerve Growth Factor Binding
	Biological Process	Ureteric Bud Development Behavioral Fear Response Response To Hypoxia Chronic Inflammatory Response Mitochondrial Electron Transport, NADH To Ubiquinone Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Nervous System Development Negative Regulation Of Neuroblast Proliferation Axon Guidance Axon Target Recognition Learning Circadian Rhythm Feeding Behavior Neuron Recognition Response To Light Intensity Response To Hormone Response To Auditory Stimulus Glutamate Secretion Response To Fluoxetine Response To Activity Dendrite Development Nerve Development Regulation Of Axon Extension Response To Food Negative Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Peptidyl-serine Phosphorylation Response To Vitamin A Response To Potassium Ion Mechanoreceptor Differentiation Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Striated Muscle Tissue Development Regulation Of Retinal Cell Programmed Cell Death Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Short-term Neuronal Synaptic Plasticity Axon Extension Neuron Projection Morphogenesis Inner Ear Development Response To Electrical Stimulus Positive Regulation Of Synapse Assembly Response To Hyperoxia Regulation Of Excitatory Postsynaptic Membrane Potential Taste Bud Development Cellular Response To Tumor Necrosis Factor Cellular Response To Norepinephrine Stimulus Response To Anesthetic Dendrite Extension Response To L-glutamate Cellular Response To Nerve Growth Factor Stimulus	Activation Of MAPK Activity Positive Regulation Of Receptor Internalization Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Neuromuscular Synaptic Transmission Nervous System Development Glial Cell Fate Determination Axon Guidance Brain Development Peripheral Nervous System Development Positive Regulation Of Cell Proliferation Epidermis Development Nerve Development Positive Regulation Of Cell Migration Activation Of Protein Kinase B Activity Activation Of Ras GTPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Mechanoreceptor Differentiation Myelination Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Glial Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Enteric Nervous System Development Neuron Projection Morphogenesis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Synaptic Transmission Positive Chemotaxis Induction Of Positive Chemotaxis Smooth Muscle Cell Differentiation Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways
Drugs
Diseases
GWAS		Body mass index ( 22344221 23563607 19079260 20935630) Obesity ( 21708048 23563607) Smoking behavior ( 20418890) Weight ( 19079260)
Protein-Protein Interactions		14 interactors: AGO3 APP CADPS2 CPE ESR1 F11R INPP5K JUNB MBTPS1 NCAM1 NOS3 NTF3 NTRK2 SORT1	5 interactors: BDNF MEOX2 NTRK1 NTRK2 NTRK3
Entrez ID		627	4908
HPRD ID		00214	01219
Ensembl ID		ENSG00000176697	ENSG00000185652
Uniprot IDs		P23560	P20783
PDB IDs		1B8M 1BND	1B8K 1BND 1NT3 3BUK
Enriched GO Terms of Interacting Partners?		Signaling Cell Surface Receptor Signaling Pathway Cell Communication Cellular Response To Organic Substance Cellular Response To Stimulus Signal Transduction Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Catalytic Activity Anatomical Structure Development Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Biosynthetic Process Developmental Process Anatomical Structure Morphogenesis Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Peptidyl-serine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cell Development Response To External Stimulus Locomotion Multicellular Organismal Development Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Process Negative Regulation Of Hydrolase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Response To Radiation Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Gene Expression Regulation Of Cellular Ketone Metabolic Process Cellular Localization Positive Regulation Of Hydrolase Activity Regulation Of Nitric-oxide Synthase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Reorganization Regulation Of Protein Phosphorylation Response To Stress Negative Regulation Of Calcium Ion Transport Neurotrophin Signaling Pathway Response To Abiotic Stimulus	Mechanoreceptor Differentiation Cellular Response To Nerve Growth Factor Stimulus Circadian Rhythm Rhythmic Process Positive Regulation Of Neuron Differentiation Regulation Of Neuron Projection Development Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Neurogenesis Regulation Of Peptidyl-serine Phosphorylation Regulation Of Cell Projection Organization Positive Regulation Of Cell Development Regulation Of Neuron Differentiation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Axonogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Neurogenesis Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Phosphorylation Response To Auditory Stimulus Negative Regulation Of Neuron Death Protein Autophosphorylation Response To Mechanical Stimulus Neurotrophin Signaling Pathway Positive Regulation Of Neuron Projection Development Regulation Of Cell Development Positive Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Positive Regulation Of Synaptic Transmission, Glutamatergic Glutamate Secretion Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Modification Process Learning Or Memory Activation Of Adenylate Cyclase Activity Negative Regulation Of Cell Death Positive Regulation Of Cell Projection Organization Positive Regulation Of Cellular Metabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Neuron Death Cognition Regulation Of Protein Phosphorylation Regulation Of Synaptic Transmission Epithelium Development Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cellular Protein Metabolic Process Neuron Differentiation Response To Electrical Stimulus Organ Development Positive Regulation Of Protein Metabolic Process
Tagcloud ?		accumulated altering believed ca2 causally cerebellar correlates dependency downregulating downregulation elicited evoked excitotoxic excitotoxicity fgf2 fibroblast fura granule neurotrophic nmda nr1 nr2a nr2c prevent protect rnase trauma trophic vulnerable	apical debatable expense fate feedback gliogenesis implying layer neocortex neocortical neurogenesis neurotrophin overproduction postmitotic precisely progenitor progenitors repressor rescue sequentially sip1 specification switch switches timing ul vi wherein zeb2
Tagcloud (Difference) ?		accumulated altering believed ca2 causally cerebellar correlates dependency downregulating downregulation elicited evoked excitotoxic excitotoxicity fgf2 fibroblast fura granule neurotrophic nmda nr1 nr2a nr2c prevent protect rnase trauma trophic vulnerable	apical debatable expense fate feedback gliogenesis implying layer neocortex neocortical neurogenesis neurotrophin overproduction postmitotic precisely progenitor progenitors repressor rescue sequentially sip1 specification switch switches timing ul vi wherein zeb2
Tagcloud (Intersection) ?