BDNF and APBA3

Data Source: HiPPIP (Novel)

		BDNF	APBA3
Name		brain derived neurotrophic factor	amyloid beta precursor protein binding family A member 3
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Synaptic Vesicle Axon Dendrite Perinuclear Region Of Cytoplasm	Cytoplasm Plasma Membrane Dendritic Spine Perinuclear Region Of Cytoplasm
	Molecular Function	Signaling Receptor Binding Nerve Growth Factor Receptor Binding Protein Binding Growth Factor Activity	Amyloid-beta Binding Enzyme Inhibitor Activity Protein Binding Enzyme Binding
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Synapse Assembly Negative Regulation Of Myotube Differentiation Positive Regulation Of Neuron Projection Development Nerve Development Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Nerve Growth Factor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Collateral Sprouting Positive Regulation Of Collateral Sprouting Neuron Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synapse Assembly Regulation Of Protein Localization To Cell Surface Negative Regulation Of Apoptotic Signaling Pathway	In Utero Embryonic Development Chemical Synaptic Transmission Regulation Of Gene Expression Protein Transport Negative Regulation Of Catalytic Activity
Pathways		PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MECP2 regulates transcription of neuronal ligands BDNF activates NTRK2 (TRKB) signaling Activated NTRK2 signals through RAS Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PI3K Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FYN NTRK2 activates RAC1 NTRK2 activates RAC1 Activated NTRK2 signals through CDK5 NPAS4 regulates expression of target genes	Neurexins and neuroligins
Drugs		CX-717 Copper Chondroitin sulfate Esketamine	None
Diseases		Congenital central hypoventilation syndrome (CCHS)	None
GWAS		Adult body size ( 32376654 ) Alcohol consumption ( 31358974 ) Apolipoprotein A1 levels ( 32203549 ) Basal metabolic rate ( 31453325 ) Basal metabolic rate variance ( 31453325 ) Blood protein levels ( 30072576 ) BMI (adjusted for smoking behaviour) ( 28443625 ) BMI in non-smokers ( 28443625 ) BMI in smokers ( 28443625 ) Body mass index ( 19079260 29381148 29273807 28892062 28552196 28448500 31453325 26961502 20935630 25673413 23563607 24861553 ) Body mass index (adult) ( 28430825 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index (joint analysis main effects and smoking interaction) ( 28443625 ) Body mass index (SNP x SNP interaction) ( 22344221 ) Body mass index in physically active individuals ( 28448500 ) Body mass index in physically inactive individuals ( 28448500 ) Body mass index variance ( 31453325 ) Body size at age 10 ( 32376654 ) Brain morphology (MOSTest) ( 32665545 ) Brain-derived neurotrophic factor levels ( 33345186 ) Caffeine consumption from coffee or tea ( 33287642 ) Childhood body mass index ( 33045005 26604143 ) Chloride levels ( 29403010 ) Chronotype ( 30696823 ) Coffee consumption ( 31959922 ) Coffee consumption (cups per day) ( 25288136 ) Coronary artery disease ( 29212778 ) Diastolic blood pressure ( 28135244 27841878 ) Diverticular disease ( 30177863 ) Falling risk ( 32999390 ) General risk tolerance (MTAG) ( 30643258 ) Hand grip strength ( 29691431 ) HDL cholesterol levels ( 32203549 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hip circumference ( 25673412 ) Menarche (age at onset) ( 27182965 ) Metabolic syndrome ( 31589552 ) Morning person ( 30696823 ) Obesity ( 23563607 21708048 ) Risk-taking tendency (4-domain principal component model) ( 30643258 ) Smoking behavior ( 20418890 ) Smoking initiation ( 33082346 30617275 ) Smoking initiation (ever regular vs never regular) ( 30679032 ) Smoking status (ever vs never smokers) ( 30643258 ) Systolic blood pressure ( 27841878 ) Triglyceride levels ( 32203549 ) Type 2 diabetes ( 32499647 ) Urinary sodium excretion ( 31409800 ) Waist circumference ( 25673412 ) Weight ( 28552196 19079260 ) White blood cell count ( 32888494 )	Serum alkaline phosphatase levels ( 33547301 )
Novel Interactors		7 novel interactors: APBA3 ARHGAP1 CD44 CD59 MBTPS2 MPPED2 PSMC3	2 novel interactors: BDNF GPX4
Interacting Genes		19 interacting genes: AGO3 APP CADPS2 CPE ESR1 F11R FAM209A GPR152 INPP5K JUNB LRP1 MBTPS1 NCAM1 NOS3 NTF3 NTF4 NTRK2 RHOU SORT1	8 interacting genes: APP ARF3 ARF4 AZI2 BCR EGFR TANK TBKBP1
Entrez ID		627	9546
HPRD ID		00214	05038
Ensembl ID		ENSG00000176697	ENSG00000011132
Uniprot IDs		A0A0E3SU01 P23560	O96018
PDB IDs		1B8M 1BND	2YT7 2YT8 5UWS
GO Terms Enriched among Interactors		Neurotrophin Signaling Pathway Nerve Growth Factor Signaling Pathway Signal Transduction Astrocyte Activation Involved In Immune Response Golgi Apparatus Membrane Developmental Process Intracellular Protein Localization Nerve Growth Factor Receptor Binding ATF6-mediated Unfolded Protein Response Regulation Of Intracellular Signal Transduction Plasma Membrane Regulation Of Signal Transduction Clathrin-coated Pit Regulation Of Vesicle-mediated Transport Regulation Of Cell Communication Regulation Of Signaling Membrane Protein Intracellular Domain Proteolysis Cellular Localization Apolipoprotein Binding Heparan Sulfate Proteoglycan Binding Astrocyte Activation Golgi Membrane Cell Surface Receptor Signaling Pathway Regulation Of Amyloid-beta Clearance Perinuclear Region Of Cytoplasm Chordate Embryonic Development In Utero Embryonic Development Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Neuron Apoptotic Process NLS-bearing Protein Import Into Nucleus Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Mechanoreceptor Differentiation Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of MiRNA Transcription Regulation Of Response To Calcium Ion Chemoattractant Activity Response To Growth Factor Amylin Binding Anatomical Structure Morphogenesis Positive Regulation Of Toll Signaling Pathway Cellular Response To Growth Factor Stimulus Early Endosome G Protein-coupled Receptor Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Receptor Internalization Dendritic Spine	Serine/threonine Protein Kinase Complex Type I Interferon-mediated Signaling Pathway Interferon-mediated Signaling Pathway Collateral Sprouting Response To External Biotic Stimulus Cell Surface Receptor Signaling Pathway Protein-containing Complex Regulation Of Reactive Oxygen Species Metabolic Process Dendritic Spine Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Synapse Organization Regulation Of Response To Calcium Ion Learning Or Memory Perinuclear Region Of Cytoplasm Amylin Binding Positive Regulation Of Toll Signaling Pathway Dendrite Development Signal Transduction Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Epidermal Growth Factor Receptor Signaling Pathway Multivesicular Body, Internal Vesicle Lumen Defense Response To Virus Positive Regulation Of Ubiquitin-specific Protease Activity Cognition Negative Regulation Of Signal Transduction Acetylcholine Receptor Activator Activity Developmental Growth Response To Interleukin-1 Plasma Membrane Bounded Cell Projection Organization Regulation Of MiRNA Transcription Negative Regulation Of Signaling Cellular Localization Lipoprotein Particle Regulation Of Programmed Cell Death Positive Regulation Of Protein Import Negative Regulation Of Cell Communication Nervous System Process ERBB Signaling Pathway Phospholipase D Activator Activity Negative Regulation Of Blood Vessel Remodeling Negative Regulation Of Neutrophil Degranulation Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Shc-EGFR Complex Regulation Of MiRNA Metabolic Process Negative Regulation Of Programmed Cell Death PTB Domain Binding Axon Collateral Sprouting In Absence Of Injury Regulation Of Protein Import