NTF3 and NTRK3

Number of citations of the paper that reports this interaction (PMID 9973222)
11

Data Source:
HPRD (in vitro, in vivo)

		NTF3	NTRK3
Gene Name		neurotrophin 3	neurotrophic tyrosine kinase, receptor, type 3
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasmic Membrane-bounded Vesicle	Cytoplasm Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Receptor Binding Neurotrophin P75 Receptor Binding Growth Factor Activity Chemoattractant Activity Nerve Growth Factor Binding	P53 Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Neurotrophin Receptor Activity Protein Binding ATP Binding Neurotrophin Binding Ephrin Receptor Binding
	Biological Process	Activation Of MAPK Activity Positive Regulation Of Receptor Internalization Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Neuromuscular Synaptic Transmission Nervous System Development Glial Cell Fate Determination Axon Guidance Brain Development Peripheral Nervous System Development Positive Regulation Of Cell Proliferation Epidermis Development Nerve Development Positive Regulation Of Cell Migration Activation Of Protein Kinase B Activity Activation Of Ras GTPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Mechanoreceptor Differentiation Myelination Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Glial Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Enteric Nervous System Development Neuron Projection Morphogenesis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Synaptic Transmission Positive Chemotaxis Induction Of Positive Chemotaxis Smooth Muscle Cell Differentiation Positive Regulation Of Actin Cytoskeleton Reorganization	Activation Of MAPK Activity Neuron Migration Negative Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Circadian Rhythm Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Peptidyl-tyrosine Phosphorylation Modulation By Virus Of Host Transcription Positive Regulation Of Cell Migration Activation Of Protein Kinase B Activity Activation Of Ras GTPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Neurotrophin Signaling Pathway Mechanoreceptor Differentiation Response To Ethanol Protein Autophosphorylation Neuron Fate Specification Response To Axon Injury Positive Regulation Of Axon Extension Involved In Regeneration Negative Regulation Of Astrocyte Differentiation Positive Regulation Of Positive Chemotaxis Response To Corticosterone Negative Regulation Of Cell Death Lens Fiber Cell Differentiation Cellular Response To Retinoic Acid Cochlea Development Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways
Drugs
Diseases
GWAS			Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Gaucher disease severity ( 22388998)
Protein-Protein Interactions		5 interactors: BDNF MEOX2 NTRK1 NTRK2 NTRK3	20 interactors: APP DOK5 DYNLL1 FRS2 HTR2A IRAK1 IRAK3 JUN KIDINS220 MAPK1 MAPK3 NGFR NGFRAP1 NTF3 PLCG1 PTPN1 RASGRF1 SHC1 SHC2 SQSTM1
Entrez ID		4908	4916
HPRD ID		01219	01870
Ensembl ID		ENSG00000185652	ENSG00000140538
Uniprot IDs		P20783	B7Z7U4 H0YND1 Q16288 Q96CY4
PDB IDs		1B8K 1BND 1NT3 3BUK	1WWC 3V5Q
Enriched GO Terms of Interacting Partners?		Mechanoreceptor Differentiation Cellular Response To Nerve Growth Factor Stimulus Circadian Rhythm Rhythmic Process Positive Regulation Of Neuron Differentiation Regulation Of Neuron Projection Development Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Neurogenesis Regulation Of Peptidyl-serine Phosphorylation Regulation Of Cell Projection Organization Positive Regulation Of Cell Development Regulation Of Neuron Differentiation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Axonogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Neurogenesis Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Phosphorylation Response To Auditory Stimulus Negative Regulation Of Neuron Death Protein Autophosphorylation Response To Mechanical Stimulus Neurotrophin Signaling Pathway Positive Regulation Of Neuron Projection Development Regulation Of Cell Development Positive Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Positive Regulation Of Synaptic Transmission, Glutamatergic Glutamate Secretion Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Modification Process Learning Or Memory Activation Of Adenylate Cyclase Activity Negative Regulation Of Cell Death Positive Regulation Of Cell Projection Organization Positive Regulation Of Cellular Metabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Neuron Death Cognition Regulation Of Protein Phosphorylation Regulation Of Synaptic Transmission Epithelium Development Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cellular Protein Metabolic Process Neuron Differentiation Response To Electrical Stimulus Organ Development Positive Regulation Of Protein Metabolic Process	Neurotrophin TRK Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Kinase Activity Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Signaling Activation Of Protein Kinase Activity Cell Communication Positive Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Regulation Of MAP Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Kinase Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of MAP Kinase Activity Positive Regulation Of Transferase Activity Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cellular Response To Organic Substance Cellular Response To Stimulus Activation Of MAPK Activity Positive Regulation Of Phosphorylation Response To Organic Substance Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Serine/threonine Kinase Activity Response To Organonitrogen Compound Positive Regulation Of Cellular Metabolic Process Response To Stimulus Positive Regulation Of Metabolic Process Immune Response-regulating Signaling Pathway Insulin Receptor Signaling Pathway Activation Of MAPKK Activity
Tagcloud ?		apical debatable expense fate feedback gliogenesis implying layer neocortex neocortical neurogenesis neurotrophin overproduction postmitotic precisely progenitor progenitors repressor rescue sequentially sip1 specification switch switches timing ul vi wherein zeb2	agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx
Tagcloud (Difference) ?		apical debatable expense fate feedback gliogenesis implying layer neocortex neocortical neurogenesis neurotrophin overproduction postmitotic precisely progenitor progenitors repressor rescue sequentially sip1 specification switch switches timing ul vi wherein zeb2	agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx
Tagcloud (Intersection) ?