NTF3 and BDNF

Number of citations: 0 (PubMedID 7703225)
Data Source: HPRD (in vitro)

		NTF3	BDNF
Name		neurotrophin 3	brain derived neurotrophic factor
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Synaptic Vesicle Axon Dendrite	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Synaptic Vesicle Axon Dendrite Perinuclear Region Of Cytoplasm
	Molecular Function	Signaling Receptor Binding Nerve Growth Factor Receptor Binding Neurotrophin Receptor Binding Protein Binding Growth Factor Activity Chemoattractant Activity	Signaling Receptor Binding Nerve Growth Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Positive Regulation Of Receptor Internalization Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Nervous System Development Positive Regulation Of Cell Population Proliferation Nerve Development Positive Regulation Of Cell Migration Nerve Growth Factor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Neuron Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Synapse Assembly Negative Regulation Of Myotube Differentiation Positive Regulation Of Neuron Projection Development Nerve Development Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Nerve Growth Factor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Collateral Sprouting Positive Regulation Of Collateral Sprouting Neuron Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synapse Assembly Regulation Of Protein Localization To Cell Surface Negative Regulation Of Apoptotic Signaling Pathway
Pathways		PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling NTF3 activates NTRK2 (TRKB) signaling NTF3 activates NTRK3 signaling NTF3 activates NTRK3 signaling Signaling by NTRK3 (TRKC) Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through RAS Activated NTRK3 signals through PI3K Activated NTRK3 signals through PI3K	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MECP2 regulates transcription of neuronal ligands BDNF activates NTRK2 (TRKB) signaling Activated NTRK2 signals through RAS Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PI3K Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FYN NTRK2 activates RAC1 NTRK2 activates RAC1 Activated NTRK2 signals through CDK5 NPAS4 regulates expression of target genes
Drugs		None	CX-717 Copper Chondroitin sulfate Esketamine
Diseases		None	Congenital central hypoventilation syndrome (CCHS)
GWAS		Blood protein levels ( 30072576 ) Insomnia ( 29520036 )	Adult body size ( 32376654 ) Alcohol consumption ( 31358974 ) Apolipoprotein A1 levels ( 32203549 ) Basal metabolic rate ( 31453325 ) Basal metabolic rate variance ( 31453325 ) Blood protein levels ( 30072576 ) BMI (adjusted for smoking behaviour) ( 28443625 ) BMI in non-smokers ( 28443625 ) BMI in smokers ( 28443625 ) Body mass index ( 19079260 29381148 29273807 28892062 28552196 28448500 31453325 26961502 20935630 25673413 23563607 24861553 ) Body mass index (adult) ( 28430825 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index (joint analysis main effects and smoking interaction) ( 28443625 ) Body mass index (SNP x SNP interaction) ( 22344221 ) Body mass index in physically active individuals ( 28448500 ) Body mass index in physically inactive individuals ( 28448500 ) Body mass index variance ( 31453325 ) Body size at age 10 ( 32376654 ) Brain morphology (MOSTest) ( 32665545 ) Brain-derived neurotrophic factor levels ( 33345186 ) Caffeine consumption from coffee or tea ( 33287642 ) Childhood body mass index ( 33045005 26604143 ) Chloride levels ( 29403010 ) Chronotype ( 30696823 ) Coffee consumption ( 31959922 ) Coffee consumption (cups per day) ( 25288136 ) Coronary artery disease ( 29212778 ) Diastolic blood pressure ( 28135244 27841878 ) Diverticular disease ( 30177863 ) Falling risk ( 32999390 ) General risk tolerance (MTAG) ( 30643258 ) Hand grip strength ( 29691431 ) HDL cholesterol levels ( 32203549 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hip circumference ( 25673412 ) Menarche (age at onset) ( 27182965 ) Metabolic syndrome ( 31589552 ) Morning person ( 30696823 ) Obesity ( 23563607 21708048 ) Risk-taking tendency (4-domain principal component model) ( 30643258 ) Smoking behavior ( 20418890 ) Smoking initiation ( 33082346 30617275 ) Smoking initiation (ever regular vs never regular) ( 30679032 ) Smoking status (ever vs never smokers) ( 30643258 ) Systolic blood pressure ( 27841878 ) Triglyceride levels ( 32203549 ) Type 2 diabetes ( 32499647 ) Urinary sodium excretion ( 31409800 ) Waist circumference ( 25673412 ) Weight ( 28552196 19079260 ) White blood cell count ( 32888494 )
Novel Interactors		None recorded	7 novel interactors: APBA3 ARHGAP1 CD44 CD59 MBTPS2 MPPED2 PSMC3
Interacting Genes		7 interacting genes: BDNF LRP1 MEOX2 NTRK1 NTRK2 NTRK3 SORT1	19 interacting genes: AGO3 APP CADPS2 CPE ESR1 F11R FAM209A GPR152 INPP5K JUNB LRP1 MBTPS1 NCAM1 NOS3 NTF3 NTF4 NTRK2 RHOU SORT1
Entrez ID		4908	627
HPRD ID		01219	00214
Ensembl ID		ENSG00000185652	ENSG00000176697
Uniprot IDs		P20783	A0A0E3SU01 P23560
PDB IDs		1B8K 1BND 1NT3 3BUK	1B8M 1BND
GO Terms Enriched among Interactors		Neurotrophin Signaling Pathway Neurotrophin Receptor Activity Neurotrophin Binding Positive Regulation Of Synapse Assembly Nerve Growth Factor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Junction Assembly Mechanoreceptor Differentiation Nerve Growth Factor Receptor Activity Positive Regulation Of Neuron Projection Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Synapse Assembly Receptor Complex Response To Nerve Growth Factor Cellular Response To Nerve Growth Factor Stimulus Brain-derived Neurotrophic Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Nerve Growth Factor Binding Regulation Of Cell Junction Assembly Positive Regulation Of Nervous System Development Positive Regulation Of Axonogenesis Regulation Of Synapse Organization GPI-linked Ephrin Receptor Activity Early Endosome Positive Regulation Of Cell Projection Organization Action Potential Propagation Neuronal Action Potential Propagation Axon Regulation Of Neuron Projection Development Regulation Of Nervous System Development Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Circadian Rhythm Regulation Of Axonogenesis Myelination In Peripheral Nervous System Positive Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Biogenesis Negative Regulation Of Neuron Apoptotic Process Nervous System Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Positive Regulation Of Neurogenesis Regulation Of Neuron Apoptotic Process Rhythmic Process Cellular Response To Growth Factor Stimulus Nerve Development Positive Regulation Of Multicellular Organismal Process Endosome Membrane	Neurotrophin Signaling Pathway Nerve Growth Factor Signaling Pathway Signal Transduction Astrocyte Activation Involved In Immune Response Golgi Apparatus Membrane Developmental Process Intracellular Protein Localization Nerve Growth Factor Receptor Binding ATF6-mediated Unfolded Protein Response Regulation Of Intracellular Signal Transduction Plasma Membrane Regulation Of Signal Transduction Clathrin-coated Pit Regulation Of Vesicle-mediated Transport Regulation Of Cell Communication Regulation Of Signaling Membrane Protein Intracellular Domain Proteolysis Cellular Localization Apolipoprotein Binding Heparan Sulfate Proteoglycan Binding Astrocyte Activation Golgi Membrane Cell Surface Receptor Signaling Pathway Regulation Of Amyloid-beta Clearance Perinuclear Region Of Cytoplasm Chordate Embryonic Development In Utero Embryonic Development Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Neuron Apoptotic Process NLS-bearing Protein Import Into Nucleus Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Mechanoreceptor Differentiation Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of MiRNA Transcription Regulation Of Response To Calcium Ion Chemoattractant Activity Response To Growth Factor Amylin Binding Anatomical Structure Morphogenesis Positive Regulation Of Toll Signaling Pathway Cellular Response To Growth Factor Stimulus Early Endosome G Protein-coupled Receptor Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Receptor Internalization Dendritic Spine