BDNF and CADPS2

Number of citations of the paper that reports this interaction (PubMedID 14715936)
60

Data Source:
HPRD (in vitro, in vivo)

		BDNF	CADPS2
Description		brain derived neurotrophic factor	calcium dependent secretion activator 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Synaptic Vesicle Axon Dendrite Perinuclear Region Of Cytoplasm	Nucleoplasm Cytoplasm Centrosome Cytoskeleton Cilium Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Ciliary Basal Body Presynaptic Membrane Cell Projection Synapse Postsynaptic Membrane Parallel Fiber To Purkinje Cell Synapse Presynapse Glutamatergic Synapse
	Molecular Function	Signaling Receptor Binding Nerve Growth Factor Receptor Binding Protein Binding Growth Factor Activity	Lipid Binding Metal Ion Binding
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Synapse Assembly Negative Regulation Of Myotube Differentiation Positive Regulation Of Neuron Projection Development Nerve Development Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Nerve Growth Factor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Collateral Sprouting Positive Regulation Of Collateral Sprouting Neuron Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synapse Assembly Regulation Of Protein Localization To Cell Surface Negative Regulation Of Apoptotic Signaling Pathway	Exocytosis Cellular Response To Starvation Protein Transport Synaptic Vesicle Exocytosis Synaptic Vesicle Priming Positive Regulation Of Exocytosis Hematopoietic Stem Cell Homeostasis Dense Core Granule Exocytosis
Pathways		PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MECP2 regulates transcription of neuronal ligands BDNF activates NTRK2 (TRKB) signaling Activated NTRK2 signals through RAS Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PI3K Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FYN NTRK2 activates RAC1 NTRK2 activates RAC1 Activated NTRK2 signals through CDK5 NPAS4 regulates expression of target genes
Drugs		CX-717 Copper Chondroitin sulfate Esketamine	Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases		Congenital central hypoventilation syndrome (CCHS)
GWAS		Adult body size ( 32376654) Alcohol consumption ( 31358974) Apolipoprotein A1 levels ( 32203549) Basal metabolic rate ( 31453325) Basal metabolic rate variance ( 31453325) Blood protein levels ( 30072576) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body mass index ( 19079260 29381148 29273807 28892062 28552196 28448500 31453325 26961502 20935630 25673413 23563607 24861553) Body mass index (adult) ( 28430825) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index (SNP x SNP interaction) ( 22344221) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body mass index variance ( 31453325) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Brain-derived neurotrophic factor levels ( 33345186) Caffeine consumption from coffee or tea ( 33287642) Childhood body mass index ( 33045005 26604143) Chloride levels ( 29403010) Chronotype ( 30696823) Coffee consumption ( 31959922) Coffee consumption (cups per day) ( 25288136) Coronary artery disease ( 29212778) Diastolic blood pressure ( 28135244 27841878) Diverticular disease ( 30177863) Falling risk ( 32999390) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hip circumference ( 25673412) Menarche (age at onset) ( 27182965) Metabolic syndrome ( 31589552) Morning person ( 30696823) Obesity ( 23563607 21708048) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking behavior ( 20418890) Smoking initiation ( 33082346 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure ( 27841878) Triglyceride levels ( 32203549) Type 2 diabetes ( 32499647) Urinary sodium excretion ( 31409800) Waist circumference ( 25673412) Weight ( 28552196 19079260) White blood cell count ( 32888494)	Adult body size ( 32376654) Attention deficit hyperactivity disorder ( 30478444 32279069) Brain structure ( 20171287) General risk tolerance (MTAG) ( 30643258) Menarche (age at onset) ( 25231870) Number of sexual partners ( 30643258) Serum sulfate level ( 27412988) Smoking status (ever vs never smokers) ( 30643258) Waist circumference ( 28552196)
Interacting Genes		19 interacting genes: AGO3 APP CADPS2 CPE ESR1 F11R FAM209A GPR152 INPP5K JUNB LRP1 MBTPS1 NCAM1 NOS3 NTF3 NTF4 NTRK2 RHOU SORT1	18 interacting genes: BDNF DMD DRD2 MEGF10 SRPK2 TMEM132D TSPOAP1 TTC3 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2U UBE2W WDR4
Entrez ID		627	93664
HPRD ID		00214	12996
Ensembl ID		ENSG00000176697	ENSG00000081803
Uniprot IDs		A0A0E3SU01 P23560	B7ZM57 Q86UW7 X5D2D9 X5D7B2 X5D8X0 X5DNG0
PDB IDs		1B8M 1BND
Enriched GO Terms of Interacting Partners?		Neurotrophin Signaling Pathway Nerve Growth Factor Signaling Pathway Signal Transduction Astrocyte Activation Involved In Immune Response Golgi Apparatus Membrane Developmental Process Intracellular Protein Localization Nerve Growth Factor Receptor Binding ATF6-mediated Unfolded Protein Response Regulation Of Intracellular Signal Transduction Plasma Membrane Regulation Of Signal Transduction Clathrin-coated Pit Regulation Of Vesicle-mediated Transport Regulation Of Cell Communication Regulation Of Signaling Membrane Protein Intracellular Domain Proteolysis Cellular Localization Apolipoprotein Binding Heparan Sulfate Proteoglycan Binding Astrocyte Activation Golgi Membrane Cell Surface Receptor Signaling Pathway Regulation Of Amyloid-beta Clearance Perinuclear Region Of Cytoplasm Chordate Embryonic Development In Utero Embryonic Development Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Neuron Apoptotic Process NLS-bearing Protein Import Into Nucleus Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Mechanoreceptor Differentiation Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of MiRNA Transcription Regulation Of Response To Calcium Ion Chemoattractant Activity Response To Growth Factor Amylin Binding Anatomical Structure Morphogenesis Positive Regulation Of Toll Signaling Pathway Cellular Response To Growth Factor Stimulus Early Endosome G Protein-coupled Receptor Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Receptor Internalization Dendritic Spine	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Post-translational Protein Modification Protein Monoubiquitination Proteolysis Involved In Protein Catabolic Process Protein K11-linked Ubiquitination Protein Modification Process Transferase Activity ATP Binding Macromolecule Catabolic Process Proteolysis Nucleotide Binding Catabolic Process Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process TORC1 Signaling Negative Regulation Of TORC1 Signaling Protein K63-linked Ubiquitination TOR Signaling Proteasomal Protein Catabolic Process Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Positive Regulation Of Protein Polyubiquitination Protein K6-linked Ubiquitination Protein Catabolic Process Regulation Of Protein Polyubiquitination Ubiquitin Protein Ligase Activity Regulation Of TOR Signaling Macromolecule Metabolic Process DNA Damage Response DNA Repair Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production TRNA Methyltransferase Activator Activity TRNA (m7G46) Methyltransferase Complex Lateral Plasma Membrane Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Sodium Ion Transport Cellular Response To Nutrient Levels Protein Autoubiquitination Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission
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