BDNF and MPPED2

Data Source: HiPPIP (Novel)

		BDNF	MPPED2
Name		brain derived neurotrophic factor	metallophosphoesterase domain containing 2
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Synaptic Vesicle Axon Dendrite Perinuclear Region Of Cytoplasm	None
	Molecular Function	Signaling Receptor Binding Nerve Growth Factor Receptor Binding Protein Binding Growth Factor Activity	Nucleotide Binding Protein Binding Phosphoric Diester Hydrolase Activity AMP Binding Hydrolase Activity GMP Binding Manganese Ion Binding Metal Ion Binding
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Synapse Assembly Negative Regulation Of Myotube Differentiation Positive Regulation Of Neuron Projection Development Nerve Development Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Nerve Growth Factor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Collateral Sprouting Positive Regulation Of Collateral Sprouting Neuron Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synapse Assembly Regulation Of Protein Localization To Cell Surface Negative Regulation Of Apoptotic Signaling Pathway	None
Pathways		PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MECP2 regulates transcription of neuronal ligands BDNF activates NTRK2 (TRKB) signaling Activated NTRK2 signals through RAS Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PI3K Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FYN NTRK2 activates RAC1 NTRK2 activates RAC1 Activated NTRK2 signals through CDK5 NPAS4 regulates expression of target genes	None
Drugs		CX-717 Copper Chondroitin sulfate Esketamine	None
Diseases		Congenital central hypoventilation syndrome (CCHS)	None
GWAS		Adult body size ( 32376654 ) Alcohol consumption ( 31358974 ) Apolipoprotein A1 levels ( 32203549 ) Basal metabolic rate ( 31453325 ) Basal metabolic rate variance ( 31453325 ) Blood protein levels ( 30072576 ) BMI (adjusted for smoking behaviour) ( 28443625 ) BMI in non-smokers ( 28443625 ) BMI in smokers ( 28443625 ) Body mass index ( 19079260 29381148 29273807 28892062 28552196 28448500 31453325 26961502 20935630 25673413 23563607 24861553 ) Body mass index (adult) ( 28430825 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index (joint analysis main effects and smoking interaction) ( 28443625 ) Body mass index (SNP x SNP interaction) ( 22344221 ) Body mass index in physically active individuals ( 28448500 ) Body mass index in physically inactive individuals ( 28448500 ) Body mass index variance ( 31453325 ) Body size at age 10 ( 32376654 ) Brain morphology (MOSTest) ( 32665545 ) Brain-derived neurotrophic factor levels ( 33345186 ) Caffeine consumption from coffee or tea ( 33287642 ) Childhood body mass index ( 33045005 26604143 ) Chloride levels ( 29403010 ) Chronotype ( 30696823 ) Coffee consumption ( 31959922 ) Coffee consumption (cups per day) ( 25288136 ) Coronary artery disease ( 29212778 ) Diastolic blood pressure ( 28135244 27841878 ) Diverticular disease ( 30177863 ) Falling risk ( 32999390 ) General risk tolerance (MTAG) ( 30643258 ) Hand grip strength ( 29691431 ) HDL cholesterol levels ( 32203549 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hip circumference ( 25673412 ) Menarche (age at onset) ( 27182965 ) Metabolic syndrome ( 31589552 ) Morning person ( 30696823 ) Obesity ( 23563607 21708048 ) Risk-taking tendency (4-domain principal component model) ( 30643258 ) Smoking behavior ( 20418890 ) Smoking initiation ( 33082346 30617275 ) Smoking initiation (ever regular vs never regular) ( 30679032 ) Smoking status (ever vs never smokers) ( 30643258 ) Systolic blood pressure ( 27841878 ) Triglyceride levels ( 32203549 ) Type 2 diabetes ( 32499647 ) Urinary sodium excretion ( 31409800 ) Waist circumference ( 25673412 ) Weight ( 28552196 19079260 ) White blood cell count ( 32888494 )	Adventurousness ( 30643258 ) Apolipoprotein B levels ( 32203549 ) Appendicular lean mass ( 33097823 ) Asthma ( 27611488 ) Automobile speeding propensity ( 30643258 ) Blood urea nitrogen levels ( 29403010 ) Chronic kidney disease ( 22479191 26831199 ) Chronotype ( 30696823 ) Creatinine levels ( 29403010 ) Dental caries ( 21940522 ) Estimated glomerular filtration rate ( 31015462 30604766 ) Falling risk ( 32999390 ) Glomerular filtration rate ( 27588450 29403010 ) Glomerular filtration rate (creatinine) ( 26831199 28452372 ) Glomerular filtration rate in non diabetics (creatinine) ( 26831199 ) HDL cholesterol levels ( 32203549 ) Hip circumference adjusted for BMI ( 34021172 ) Major depressive disorder ( 27479909 ) Medication use (diuretics) ( 31015401 ) Migraine ( 27322543 ) Morning person ( 30696823 ) Pit-and-Fissure caries ( 24556642 ) PR interval ( 32439900 ) Refractive error ( 32231278 ) Renal function-related traits (eGRFcrea) ( 22797727 ) Renal function-related traits (sCR) ( 22797727 ) Serum uric acid levels ( 30993211 29403010 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Systolic blood pressure ( 30578418 ) Triglyceride levels ( 32203549 ) Urate levels ( 31578528 )
Novel Interactors		7 novel interactors: APBA3 ARHGAP1 CD44 CD59 MBTPS2 MPPED2 PSMC3	3 novel interactors: BDNF GCH1 PAX6
Interacting Genes		19 interacting genes: AGO3 APP CADPS2 CPE ESR1 F11R FAM209A GPR152 INPP5K JUNB LRP1 MBTPS1 NCAM1 NOS3 NTF3 NTF4 NTRK2 RHOU SORT1	14 interacting genes: BEX4 CAGE1 FAM72A HOOK2 IKZF1 MBD3L1 NOTCH3 NUP93 POMP RIBC1 RUNX1 RXRG TRIP13 VAC14
Entrez ID		627	744
HPRD ID		00214	02947
Ensembl ID		ENSG00000176697	ENSG00000066382
Uniprot IDs		A0A0E3SU01 P23560	Q15777
PDB IDs		1B8M 1BND	Not available
GO Terms Enriched among Interactors		Neurotrophin Signaling Pathway Nerve Growth Factor Signaling Pathway Signal Transduction Astrocyte Activation Involved In Immune Response Golgi Apparatus Membrane Developmental Process Intracellular Protein Localization Nerve Growth Factor Receptor Binding ATF6-mediated Unfolded Protein Response Regulation Of Intracellular Signal Transduction Plasma Membrane Regulation Of Signal Transduction Clathrin-coated Pit Regulation Of Vesicle-mediated Transport Regulation Of Cell Communication Regulation Of Signaling Membrane Protein Intracellular Domain Proteolysis Cellular Localization Apolipoprotein Binding Heparan Sulfate Proteoglycan Binding Astrocyte Activation Golgi Membrane Cell Surface Receptor Signaling Pathway Regulation Of Amyloid-beta Clearance Perinuclear Region Of Cytoplasm Chordate Embryonic Development In Utero Embryonic Development Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Neuron Apoptotic Process NLS-bearing Protein Import Into Nucleus Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Mechanoreceptor Differentiation Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of MiRNA Transcription Regulation Of Response To Calcium Ion Chemoattractant Activity Response To Growth Factor Amylin Binding Anatomical Structure Morphogenesis Positive Regulation Of Toll Signaling Pathway Cellular Response To Growth Factor Stimulus Early Endosome G Protein-coupled Receptor Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Receptor Internalization Dendritic Spine	None