NTF3

Description		neurotrophin 3
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Synaptic Vesicle Axon Dendrite
	Molecular Function	Signaling Receptor Binding Nerve Growth Factor Receptor Binding Neurotrophin Receptor Binding Protein Binding Growth Factor Activity Chemoattractant Activity
	Biological Process	Positive Regulation Of Receptor Internalization Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Nervous System Development Positive Regulation Of Cell Population Proliferation Nerve Development Positive Regulation Of Cell Migration Nerve Growth Factor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Neuron Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways		PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling NTF3 activates NTRK2 (TRKB) signaling NTF3 activates NTRK3 signaling NTF3 activates NTRK3 signaling Signaling by NTRK3 (TRKC) Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through RAS Activated NTRK3 signals through PI3K Activated NTRK3 signals through PI3K
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Insomnia ( 29520036)
Interacting Genes		7 interacting genes: BDNF LRP1 MEOX2 NTRK1 NTRK2 NTRK3 SORT1
Entrez ID		4908
HPRD ID		01219
Ensembl ID		ENSG00000185652
Uniprot IDs		P20783
PDB IDs		1B8K 1BND 1NT3 3BUK
Enriched GO Terms of Interacting Partners?		Neurotrophin Signaling Pathway Neurotrophin Receptor Activity Neurotrophin Binding Positive Regulation Of Synapse Assembly Nerve Growth Factor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Junction Assembly Mechanoreceptor Differentiation Nerve Growth Factor Receptor Activity Positive Regulation Of Neuron Projection Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Synapse Assembly Receptor Complex Response To Nerve Growth Factor Cellular Response To Nerve Growth Factor Stimulus Brain-derived Neurotrophic Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Nerve Growth Factor Binding Regulation Of Cell Junction Assembly Positive Regulation Of Nervous System Development Positive Regulation Of Axonogenesis Regulation Of Synapse Organization GPI-linked Ephrin Receptor Activity Early Endosome Positive Regulation Of Cell Projection Organization Action Potential Propagation Neuronal Action Potential Propagation Axon Regulation Of Neuron Projection Development Regulation Of Nervous System Development Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Circadian Rhythm Regulation Of Axonogenesis Myelination In Peripheral Nervous System Positive Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Biogenesis Negative Regulation Of Neuron Apoptotic Process Nervous System Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Positive Regulation Of Neurogenesis Regulation Of Neuron Apoptotic Process Rhythmic Process Cellular Response To Growth Factor Stimulus Nerve Development Positive Regulation Of Multicellular Organismal Process Endosome Membrane
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