NTF3 and SORT1

Number of citations of the paper that reports this interaction (PubMedID 21261755)
27

Data Source:
BioGRID (pull down)

		NTF3	SORT1
Description		neurotrophin 3	sortilin 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Synaptic Vesicle Axon Dendrite	Nucleus Lysosome Lysosomal Membrane Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Clathrin-coated Pit Cell Surface Endosome Membrane Membrane Clathrin-coated Vesicle Trans-Golgi Network Transport Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Nuclear Membrane Golgi Cisterna Membrane Perinuclear Region Of Cytoplasm Cerebellar Climbing Fiber To Purkinje Cell Synapse
	Molecular Function	Signaling Receptor Binding Nerve Growth Factor Receptor Binding Neurotrophin Receptor Binding Protein Binding Growth Factor Activity Chemoattractant Activity	Protein Binding Nerve Growth Factor Receptor Activity Enzyme Binding Neurotensin Receptor Activity, Non-G Protein-coupled Nerve Growth Factor Binding Retromer Complex Binding
	Biological Process	Positive Regulation Of Receptor Internalization Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Nervous System Development Positive Regulation Of Cell Population Proliferation Nerve Development Positive Regulation Of Cell Migration Nerve Growth Factor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Neuron Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Ossification Protein Targeting To Lysosome Golgi To Endosome Transport Endocytosis G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Endosome To Lysosome Transport Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Gene Expression Myotube Differentiation Vesicle Organization Cell Differentiation Endosome Transport Via Multivesicular Body Sorting Pathway Response To Insulin Nerve Growth Factor Signaling Pathway Negative Regulation Of Fat Cell Differentiation D-glucose Import Neurotrophin TRK Receptor Signaling Pathway Plasma Membrane To Endosome Transport Golgi To Lysosome Transport Maintenance Of Synapse Structure
Pathways		PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling NTF3 activates NTRK2 (TRKB) signaling NTF3 activates NTRK3 signaling NTF3 activates NTRK3 signaling Signaling by NTRK3 (TRKC) Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through RAS Activated NTRK3 signals through PI3K Activated NTRK3 signals through PI3K	Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Insomnia ( 29520036)	Abdominal aortic aneurysm ( 27899403) Appendicular lean mass ( 33097823) Cholesterol, total ( 24097068 25961943 20686565) Chronic kidney disease ( 20383146) Cognitive ability ( 29186694) Coronary artery disease ( 21239051 24262325 26343387 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 21378988 21378990) Coronary heart disease x type 2 diabetes interaction ( 32541925) HDL cholesterol ( 25961943) LDL cholesterol ( 18193044 25961943 18193043 19060906 19060910 24097068 20686565 21347282) LDL cholesterol levels ( 26690388 28334899) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Low density lipoprotein cholesterol levels ( 30718733) Metabolite levels ( 21909109) Myocardial infarction ( 26343387) Myocardial infarction (early onset) ( 19198609) Peripheral artery disease ( 31285632) Progranulin levels ( 21087763 29186428) Ratio of apolipoprotein A1 to apolipoprotein B ( 29084231) Response to statin therapy ( 20339536) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189) Total cholesterol levels ( 28334899)
Interacting Genes		7 interacting genes: BDNF LRP1 MEOX2 NTRK1 NTRK2 NTRK3 SORT1	17 interacting genes: ADGRG7 BDNF BRICD5 CNIH3 GGA1 GGA2 LRPAP1 NGF NGFR NTF3 NTRK1 NTRK2 NTRK3 NTS SORCS1 SORL1 TF
Entrez ID		4908	6272
HPRD ID		01219	03910
Ensembl ID		ENSG00000185652	ENSG00000134243
Uniprot IDs		P20783	Q99523
PDB IDs		1B8K 1BND 1NT3 3BUK	3F6K 3G2U 3G2V 4MSL 4N7E 4PO7 5MRH 5MRI 6EHO 6X3L 6X48 6X4H 8T8R 8T8S
Enriched GO Terms of Interacting Partners?		Neurotrophin Signaling Pathway Neurotrophin Receptor Activity Neurotrophin Binding Positive Regulation Of Synapse Assembly Nerve Growth Factor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Junction Assembly Mechanoreceptor Differentiation Nerve Growth Factor Receptor Activity Positive Regulation Of Neuron Projection Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Synapse Assembly Receptor Complex Response To Nerve Growth Factor Cellular Response To Nerve Growth Factor Stimulus Brain-derived Neurotrophic Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Nerve Growth Factor Binding Regulation Of Cell Junction Assembly Positive Regulation Of Nervous System Development Positive Regulation Of Axonogenesis Regulation Of Synapse Organization GPI-linked Ephrin Receptor Activity Early Endosome Positive Regulation Of Cell Projection Organization Action Potential Propagation Neuronal Action Potential Propagation Axon Regulation Of Neuron Projection Development Regulation Of Nervous System Development Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Circadian Rhythm Regulation Of Axonogenesis Myelination In Peripheral Nervous System Positive Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Biogenesis Negative Regulation Of Neuron Apoptotic Process Nervous System Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Positive Regulation Of Neurogenesis Regulation Of Neuron Apoptotic Process Rhythmic Process Cellular Response To Growth Factor Stimulus Nerve Development Positive Regulation Of Multicellular Organismal Process Endosome Membrane	Neurotrophin Signaling Pathway Neurotrophin Binding Nerve Development Nerve Growth Factor Signaling Pathway Neurotrophin Receptor Activity Nerve Growth Factor Receptor Binding Endosome Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Circadian Rhythm Endosome Membrane Positive Regulation Of Neuron Projection Development Positive Regulation Of Synapse Assembly Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Axonogenesis Early Endosome Membrane Enzyme-linked Receptor Protein Signaling Pathway Axon Mechanoreceptor Differentiation Regulation Of Nervous System Development Post-Golgi Vesicle-mediated Transport Positive Regulation Of Cell Junction Assembly Dendrite Regulation Of Neuron Apoptotic Process Rhythmic Process Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Nervous System Development Modulation Of Chemical Synaptic Transmission Positive Regulation Of Signal Transduction Nerve Growth Factor Binding Cellular Response To Nerve Growth Factor Stimulus Regulation Of Axonogenesis Signal Transduction Nervous System Development Early Endosome Response To Nerve Growth Factor Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Synapse Assembly Transmembrane Receptor Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Positive Regulation Of Cell Projection Organization Regulation Of Neurogenesis Regulation Of Signal Transduction Establishment Of Protein Localization To Plasma Membrane System Development Signaling Receptor Binding Cell Surface Receptor Signaling Pathway Regulation Of Neuron Projection Development
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?