BDNF and AGO3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		BDNF	AGO3
Description		brain derived neurotrophic factor	argonaute RISC catalytic component 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Synaptic Vesicle Axon Dendrite Perinuclear Region Of Cytoplasm	Condensed Nuclear Chromosome P-body Nucleus Nucleoplasm Cytoplasm Cytosol Membrane RISC Complex Cytoplasmic Ribonucleoprotein Granule RISC-loading Complex Ribonucleoprotein Complex
	Molecular Function	Signaling Receptor Binding Nerve Growth Factor Receptor Binding Protein Binding Growth Factor Activity	Nucleic Acid Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity Protein Binding Hydrolase Activity MiRNA Binding Metal Ion Binding Endoribonuclease Activity, Cleaving MiRNA-paired MRNA
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Synapse Assembly Negative Regulation Of Myotube Differentiation Positive Regulation Of Neuron Projection Development Nerve Development Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Nerve Growth Factor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Collateral Sprouting Positive Regulation Of Collateral Sprouting Neuron Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synapse Assembly Regulation Of Protein Localization To Cell Surface Negative Regulation Of Apoptotic Signaling Pathway	MRNA Catabolic Process Regulation Of Translation Positive Regulation Of Gene Expression Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MiRNA Processing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization RISC Complex Assembly Regulation Of Stem Cell Proliferation SiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MECP2 regulates transcription of neuronal ligands BDNF activates NTRK2 (TRKB) signaling Activated NTRK2 signals through RAS Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PI3K Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FYN NTRK2 activates RAC1 NTRK2 activates RAC1 Activated NTRK2 signals through CDK5 NPAS4 regulates expression of target genes	Pre-NOTCH Transcription and Translation MicroRNA (miRNA) biogenesis Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Small interfering RNA (siRNA) biogenesis Post-transcriptional silencing by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Nuclear events stimulated by ALK signaling in cancer Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH1 mRNA translation by microRNAs Regulation of NPAS4 mRNA translation Regulation of MITF-M-dependent genes involved in apoptosis TGFBR3 expression Regulation of PD-L1(CD274) translation
Drugs		CX-717 Copper Chondroitin sulfate Esketamine
Diseases		Congenital central hypoventilation syndrome (CCHS)
GWAS		Adult body size ( 32376654) Alcohol consumption ( 31358974) Apolipoprotein A1 levels ( 32203549) Basal metabolic rate ( 31453325) Basal metabolic rate variance ( 31453325) Blood protein levels ( 30072576) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body mass index ( 19079260 29381148 29273807 28892062 28552196 28448500 31453325 26961502 20935630 25673413 23563607 24861553) Body mass index (adult) ( 28430825) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index (SNP x SNP interaction) ( 22344221) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body mass index variance ( 31453325) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Brain-derived neurotrophic factor levels ( 33345186) Caffeine consumption from coffee or tea ( 33287642) Childhood body mass index ( 33045005 26604143) Chloride levels ( 29403010) Chronotype ( 30696823) Coffee consumption ( 31959922) Coffee consumption (cups per day) ( 25288136) Coronary artery disease ( 29212778) Diastolic blood pressure ( 28135244 27841878) Diverticular disease ( 30177863) Falling risk ( 32999390) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hip circumference ( 25673412) Menarche (age at onset) ( 27182965) Metabolic syndrome ( 31589552) Morning person ( 30696823) Obesity ( 23563607 21708048) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking behavior ( 20418890) Smoking initiation ( 33082346 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure ( 27841878) Triglyceride levels ( 32203549) Type 2 diabetes ( 32499647) Urinary sodium excretion ( 31409800) Waist circumference ( 25673412) Weight ( 28552196 19079260) White blood cell count ( 32888494)
Interacting Genes		19 interacting genes: AGO3 APP CADPS2 CPE ESR1 F11R FAM209A GPR152 INPP5K JUNB LRP1 MBTPS1 NCAM1 NOS3 NTF3 NTF4 NTRK2 RHOU SORT1	5 interacting genes: ATP4B ATP6V0D2 BDNF CFTR SLC22A2
Entrez ID		627	192669
HPRD ID		00214	09558
Ensembl ID		ENSG00000176697	ENSG00000126070
Uniprot IDs		A0A0E3SU01 P23560	B4E1P5 Q9H9G7
PDB IDs		1B8M 1BND	5VM9 8VAJ
Enriched GO Terms of Interacting Partners?		Neurotrophin Signaling Pathway Nerve Growth Factor Signaling Pathway Signal Transduction Astrocyte Activation Involved In Immune Response Golgi Apparatus Membrane Developmental Process Intracellular Protein Localization Nerve Growth Factor Receptor Binding ATF6-mediated Unfolded Protein Response Regulation Of Intracellular Signal Transduction Plasma Membrane Regulation Of Signal Transduction Clathrin-coated Pit Regulation Of Vesicle-mediated Transport Regulation Of Cell Communication Regulation Of Signaling Membrane Protein Intracellular Domain Proteolysis Cellular Localization Apolipoprotein Binding Heparan Sulfate Proteoglycan Binding Astrocyte Activation Golgi Membrane Cell Surface Receptor Signaling Pathway Regulation Of Amyloid-beta Clearance Perinuclear Region Of Cytoplasm Chordate Embryonic Development In Utero Embryonic Development Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Neuron Apoptotic Process NLS-bearing Protein Import Into Nucleus Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Mechanoreceptor Differentiation Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of MiRNA Transcription Regulation Of Response To Calcium Ion Chemoattractant Activity Response To Growth Factor Amylin Binding Anatomical Structure Morphogenesis Positive Regulation Of Toll Signaling Pathway Cellular Response To Growth Factor Stimulus Early Endosome G Protein-coupled Receptor Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Receptor Internalization Dendritic Spine	Regulation Of PH Apical Plasma Membrane Intracellular Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Transmembrane Transport Export Across Plasma Membrane Monoatomic Ion Transport Intracellular Monoatomic Cation Homeostasis Early Endosome Regulation Of Cellular PH Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Intracellular PH C-X-C Motif Chemokine 12 Receptor Activity Monoatomic Ion Homeostasis Cellular Homeostasis Import Across Plasma Membrane Inorganic Ion Transmembrane Transport P-type Potassium:proton Transporter Activity Potassium:proton Exchanging ATPase Complex Intracellular Chemical Homeostasis Proton Transmembrane Transport Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Anion Channel Activity Positive Regulation Of Enamel Mineralization Organic Hydroxy Compound Transport Positive Regulation Of Monoatomic Anion Transport Acetylcholine Transport Histamine Uptake Pyrimidine Nucleoside Transmembrane Transporter Activity Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Amine Transmembrane Transporter Activity Spermidine Transmembrane Transporter Activity L-arginine Import Across Plasma Membrane Putrescine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Plasma Membrane Proton-transporting V-type ATPase Complex Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Nerve Growth Factor Receptor Binding Endosome Transepithelial Water Transport Spermidine Transport Thiamine Transmembrane Transporter Activity
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