RPS27 and PPBP

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		RPS27	PPBP
Gene Name		ribosomal protein S27	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Ribosome Cytosolic Small Ribosomal Subunit	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen
	Molecular Function	DNA Binding Structural Constituent Of Ribosome Protein Binding Zinc Ion Binding Poly(A) RNA Binding	Glucose Transmembrane Transporter Activity Chemokine Activity Growth Factor Activity CXCR Chemokine Receptor Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Mitotic Cell Cycle Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Cell Proliferation Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process	Leukocyte Migration Involved In Inflammatory Response Platelet Degranulation Positive Regulation Of Leukocyte Chemotaxis Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Blood Coagulation Glucose Transport Platelet Activation Response To Lipopolysaccharide Regulation Of Cell Proliferation Defense Response To Bacterium Positive Regulation Of Cell Division Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Translation initiation complex formation Mitotic Prometaphase Separation of Sister Chromatids Peptide chain elongation Mitotic Anaphase M Phase Influenza Life Cycle Formation of the ternary complex, and subsequently, the 43S complex Influenza Viral RNA Transcription and Replication Eukaryotic Translation Initiation Cap-dependent Translation Initiation Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Viral mRNA Translation Influenza Infection L13a-mediated translational silencing of Ceruloplasmin expression Cell Cycle, Mitotic Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Resolution of Sister Chromatid Cohesion Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Mitotic Metaphase and Anaphase Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Platelet degranulation GPCR ligand binding Metabolic disorders of biological oxidation enzymes GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Response to elevated platelet cytosolic Ca2+ G alpha (i) signalling events Platelet activation, signaling and aggregation
Drugs			Ethanesulfonic Acid
Diseases
GWAS			Metabolite levels ( 22916037)
Protein-Protein Interactions		13 interactors: ACTN1 ACTN4 APC C2orf44 ENOPH1 ENTPD4 HMP19 MARS NACAD PPBP RTN4 SKIL TOM1	21 interactors: CELF1 CMTM6 COPG1 COPS7A COX17 CSNK2A1 CTSG CXCR1 CXCR2 DMWD EFNA1 MAPK6 MOB3B NDUFB11 NR4A1 PLEKHJ1 PMAIP1 RAB10 RPS27 SCFD1 STRN4
Entrez ID		6232	5473
HPRD ID		04744	07171
Ensembl ID		ENSG00000177954
Uniprot IDs		P42677	P02775
PDB IDs		3J3A	1F9P 1NAP 1TVX
Enriched GO Terms of Interacting Partners?		Protein Localization To Tight Junction Tight Junction Assembly Protein Localization To Cell Junction Platelet Degranulation Apical Junction Assembly Regulation Of Cellular Component Movement Cell-cell Junction Assembly Actin Crosslink Formation Platelet Activation Cell Junction Assembly Cell-cell Junction Organization Cellular Component Assembly Cell Activation Actin Filament Bundle Assembly UDP Catabolic Process Vesicle-mediated Transport Regulation Of Apoptotic Process Exocytosis Positive Regulation Of Cellular Component Movement Regulation Of Cell Death Methionyl-tRNA Aminoacylation Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Blood Coagulation Hemostasis Regulation Of Branching Morphogenesis Of A Nerve Positive Regulation Of Pinocytosis Protein Complex Assembly Regulation Of Cell Projection Organization Positive Regulation Of Cell Division Positive Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Odontogenesis Secretion By Cell Cell Cycle Arrest Regulation Of Sodium:proton Antiporter Activity Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Axonogenesis Regulation Of Body Fluid Levels Regulation Of Cell Migration Metaphase/anaphase Transition Of Mitotic Cell Cycle Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Wound Healing L-methionine Biosynthetic Process From Methylthioadenosine Ribonucleoside Diphosphate Catabolic Process Endoplasmic Reticulum Tubular Network Organization Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Regulation Of Cell Motility Secretion Nucleoside Diphosphate Catabolic Process L-methionine Salvage Regulation Of Locomotion	Interleukin-8-mediated Signaling Pathway Chemotaxis Response To External Stimulus Dendritic Cell Chemotaxis Dendritic Cell Migration Locomotion Cell Chemotaxis Retrograde Vesicle-mediated Transport, Golgi To ER Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Receptor Internalization Movement Of Cell Or Subcellular Component Vesicle Docking Involved In Exocytosis Negative Regulation Of Neutrophil Apoptotic Process Basolateral Protein Localization Chemokine-mediated Signaling Pathway Golgi Vesicle Transport Vesicle Docking Neutrophil Mediated Killing Of Gram-positive Bacterium Receptor Metabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Membrane Docking Post-Golgi Vesicle-mediated Transport Negative Regulation Of Dendritic Spine Morphogenesis Negative Regulation Of Autophagic Vacuole Assembly Establishment Of Neuroblast Polarity Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Defense Response Leukocyte Chemotaxis Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Endopeptidase Activity Cell Migration Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Membrane Organization Regulation Of Peptidase Activity Vesicle-mediated Transport Immune System Process Negative Regulation Of Mitochondrial Membrane Potential Aortic Valve Morphogenesis Endocardial Cushion To Mesenchymal Transition Notochord Formation Cell Motility Regulation Of Protein Metabolic Process Protein Localization To Endoplasmic Reticulum Intracellular Transport Acute Inflammatory Response To Antigenic Stimulus Negative Regulation Of Dendritic Spine Development Mitral Valve Morphogenesis Mitral Valve Development
Tagcloud ?			10q 4q another chemokine constitutes cr cxc divergent evolutionary gcp2 genbridge gro1 gro2 gro3 il8 inp10 mapped mentioned mig pair panel pf4 pf4v1 phylogenetic physically primers scyb5 sdf1 separated
Tagcloud (Difference) ?			10q 4q another chemokine constitutes cr cxc divergent evolutionary gcp2 genbridge gro1 gro2 gro3 il8 inp10 mapped mentioned mig pair panel pf4 pf4v1 phylogenetic physically primers scyb5 sdf1 separated
Tagcloud (Intersection) ?