PPBP and MOB3B

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		PPBP	MOB3B
Gene Name		pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	MOB kinase activator 3B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen
	Molecular Function	Glucose Transmembrane Transporter Activity Chemokine Activity Growth Factor Activity CXCR Chemokine Receptor Binding	Protein Binding Metal Ion Binding
	Biological Process	Leukocyte Migration Involved In Inflammatory Response Platelet Degranulation Positive Regulation Of Leukocyte Chemotaxis Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Blood Coagulation Glucose Transport Platelet Activation Response To Lipopolysaccharide Regulation Of Cell Proliferation Defense Response To Bacterium Positive Regulation Of Cell Division Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Platelet degranulation GPCR ligand binding Metabolic disorders of biological oxidation enzymes GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Response to elevated platelet cytosolic Ca2+ G alpha (i) signalling events Platelet activation, signaling and aggregation
Drugs		Ethanesulfonic Acid
Diseases
GWAS		Metabolite levels ( 22916037)	Urinary symptoms in response to radiotherapy in prostate cancer ( 23376709)
Protein-Protein Interactions		21 interactors: CELF1 CMTM6 COPG1 COPS7A COX17 CSNK2A1 CTSG CXCR1 CXCR2 DMWD EFNA1 MAPK6 MOB3B NDUFB11 NR4A1 PLEKHJ1 PMAIP1 RAB10 RPS27 SCFD1 STRN4	5 interactors: LATS1 LATS2 MAPK14 NT5C2 PPBP
Entrez ID		5473	79817
HPRD ID		07171	14728
Ensembl ID			ENSG00000120162
Uniprot IDs		P02775	Q86TA1
PDB IDs		1F9P 1NAP 1TVX
Enriched GO Terms of Interacting Partners?		Interleukin-8-mediated Signaling Pathway Chemotaxis Response To External Stimulus Dendritic Cell Chemotaxis Dendritic Cell Migration Locomotion Cell Chemotaxis Retrograde Vesicle-mediated Transport, Golgi To ER Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Receptor Internalization Movement Of Cell Or Subcellular Component Vesicle Docking Involved In Exocytosis Negative Regulation Of Neutrophil Apoptotic Process Basolateral Protein Localization Chemokine-mediated Signaling Pathway Golgi Vesicle Transport Vesicle Docking Neutrophil Mediated Killing Of Gram-positive Bacterium Receptor Metabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Membrane Docking Post-Golgi Vesicle-mediated Transport Negative Regulation Of Dendritic Spine Morphogenesis Negative Regulation Of Autophagic Vacuole Assembly Establishment Of Neuroblast Polarity Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Defense Response Leukocyte Chemotaxis Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Endopeptidase Activity Cell Migration Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Membrane Organization Regulation Of Peptidase Activity Vesicle-mediated Transport Immune System Process Negative Regulation Of Mitochondrial Membrane Potential Aortic Valve Morphogenesis Endocardial Cushion To Mesenchymal Transition Notochord Formation Cell Motility Regulation Of Protein Metabolic Process Protein Localization To Endoplasmic Reticulum Intracellular Transport Acute Inflammatory Response To Antigenic Stimulus Negative Regulation Of Dendritic Spine Development Mitral Valve Morphogenesis Mitral Valve Development	Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Hippo Signaling Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Wnt Signaling Pathway Keratinocyte Differentiation Phosphorylation Cellular Response To Organic Substance Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity P38MAPK Cascade Regulation Of Protein Kinase Activity Negative Regulation Of Protein Serine/threonine Kinase Activity Epidermal Cell Differentiation Hormone-mediated Signaling Pathway Regulation Of Kinase Activity Response To Organic Substance Platelet Activation Cell Cycle Process Negative Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Skin Development Negative Regulation Of Signal Transduction Negative Regulation Of Kinase Activity Positive Regulation Of Brown Fat Cell Differentiation Myoblast Differentiation Involved In Skeletal Muscle Regeneration Phosphate-containing Compound Metabolic Process Negative Regulation Of Signaling Regulation Of Brown Fat Cell Differentiation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Epidermis Development Regulation Of Phosphorylation Negative Regulation Of Transferase Activity Protein Phosphorylation Cell Cycle Mitotic Nuclear Division Response To Lipopolysaccharide Negative Regulation Of Protein Phosphorylation Response To Molecule Of Bacterial Origin 3'-UTR-mediated MRNA Stabilization Regulation Of Phosphorus Metabolic Process Stress-induced Premature Senescence Negative Regulation Of Phosphorylation Blood Coagulation Cell Division Hemostasis Adenosine Metabolic Process Tissue Development Negative Regulation Of Cell Cycle
Tagcloud ?		10q 4q another chemokine constitutes cr cxc divergent evolutionary gcp2 genbridge gro1 gro2 gro3 il8 inp10 mapped mentioned mig pair panel pf4 pf4v1 phylogenetic physically primers scyb5 sdf1 separated
Tagcloud (Difference) ?		10q 4q another chemokine constitutes cr cxc divergent evolutionary gcp2 genbridge gro1 gro2 gro3 il8 inp10 mapped mentioned mig pair panel pf4 pf4v1 phylogenetic physically primers scyb5 sdf1 separated
Tagcloud (Intersection) ?