PPBP and COX17

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PPBP	COX17
Description		pro-platelet basic protein	cytochrome c oxidase copper chaperone COX17
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Platelet Alpha Granule Lumen Tertiary Granule Lumen	Cytoplasm Mitochondrion Mitochondrial Intermembrane Space
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity Growth Factor Activity CXCR Chemokine Receptor Binding D-glucose Transmembrane Transporter Activity	Copper Ion Binding Protein Binding Enzyme Activator Activity Copper Chaperone Activity Metal Ion Binding Cuprous Ion Binding
	Biological Process	Chemotaxis Defense Response Inflammatory Response Immune Response Signal Transduction Neutrophil Chemotaxis Killing Of Cells Of Another Organism Defense Response To Bacterium Positive Regulation Of Cell Division Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide D-glucose Transmembrane Transport	Generation Of Precursor Metabolites And Energy Copper Ion Transport Heart Development Positive Regulation Of Cell Population Proliferation Mitochondrial Cytochrome C Oxidase Assembly Positive Regulation Of Cytochrome-c Oxidase Activity
Pathways		Platelet degranulation Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation	Mitochondrial protein import Complex IV assembly
Drugs		Ethanesulfonic acid Copper
Diseases
GWAS		Metabolite levels ( 22916037)	Tau burden ( 33426524)
Interacting Genes		32 interacting genes: CCL13 CCL21 CCL26 CCL28 CCL5 CCL8 CELF1 CMTM6 COPG1 COPS7A COX17 CTSG CXCL10 CXCL11 CXCL12 CXCL14 CXCL6 CXCL9 CXCR1 CXCR2 DMWD EFNA1 MAPK6 MOB3B NDUFB11 NR4A1 PLEKHJ1 PMAIP1 RAB10 RPS27 SCFD1 STRN4	12 interacting genes: COPS6 EEF1A1 ERG28 HADHB KATNAL1 KRTAP10-8 LRIF1 PPBP RBM48 TP53 UBC UNC119
Entrez ID		5473	10063
HPRD ID		07171	05314
Ensembl ID		ENSG00000163736	ENSG00000138495
Uniprot IDs		P02775	C9J8T6 Q14061
PDB IDs		1F9P 1NAP 1TVX	2L0Y 2LGQ 2RN9 2RNB
Enriched GO Terms of Interacting Partners?		Chemokine Activity Cell Chemotaxis Leukocyte Chemotaxis Chemokine-mediated Signaling Pathway Chemotaxis Locomotion Antimicrobial Humoral Response Granulocyte Chemotaxis Leukocyte Migration Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Myeloid Leukocyte Migration Granulocyte Migration Humoral Immune Response Cytokine Activity Killing Of Cells Of Another Organism Cell Migration Cytokine-mediated Signaling Pathway Mononuclear Cell Migration Cell Motility Cell Killing CXCR Chemokine Receptor Binding Inflammatory Response Eosinophil Chemotaxis Defense Response To Symbiont Eosinophil Migration Defense Response Defense Response To Other Organism Immune System Process Neutrophil Chemotaxis Immune Response CCR Chemokine Receptor Binding Chemokine Receptor Binding Neutrophil Migration Response To External Biotic Stimulus Response To Other Organism Cell-cell Signaling G Protein-coupled Receptor Signaling Pathway Signaling Cell Communication T Cell Chemotaxis Dendritic Cell Chemotaxis Negative Regulation Of Leukocyte Tethering Or Rolling CXCR3 Chemokine Receptor Binding Dendritic Cell Migration Lymphocyte Chemotaxis Neutrophil Activation Negative Regulation Of Cellular Extravasation T Cell Migration Positive Regulation Of T Cell Migration Extracellular Space	Glial Cell Apoptotic Process Negative Regulation Of Glial Cell Proliferation Disordered Domain Specific Binding Glial Cell Proliferation
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