PPBP and NDUFB11

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		PPBP	NDUFB11
Gene Name		pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I Integral Component Of Membrane
	Molecular Function	Glucose Transmembrane Transporter Activity Chemokine Activity Growth Factor Activity CXCR Chemokine Receptor Binding
	Biological Process	Leukocyte Migration Involved In Inflammatory Response Platelet Degranulation Positive Regulation Of Leukocyte Chemotaxis Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Blood Coagulation Glucose Transport Platelet Activation Response To Lipopolysaccharide Regulation Of Cell Proliferation Defense Response To Bacterium Positive Regulation Of Cell Division Cell Chemotaxis Chemokine-mediated Signaling Pathway	Respiratory Electron Transport Chain Cellular Metabolic Process Small Molecule Metabolic Process
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Platelet degranulation GPCR ligand binding Metabolic disorders of biological oxidation enzymes GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Response to elevated platelet cytosolic Ca2+ G alpha (i) signalling events Platelet activation, signaling and aggregation	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport
Drugs		Ethanesulfonic Acid
Diseases
GWAS		Metabolite levels ( 22916037)
Protein-Protein Interactions		21 interactors: CELF1 CMTM6 COPG1 COPS7A COX17 CSNK2A1 CTSG CXCR1 CXCR2 DMWD EFNA1 MAPK6 MOB3B NDUFB11 NR4A1 PLEKHJ1 PMAIP1 RAB10 RPS27 SCFD1 STRN4	3 interactors: BAG6 FATE1 PPBP
Entrez ID		5473	54539
HPRD ID		07171	02323
Ensembl ID			ENSG00000147123
Uniprot IDs		P02775	Q9NX14
PDB IDs		1F9P 1NAP 1TVX
Enriched GO Terms of Interacting Partners?		Interleukin-8-mediated Signaling Pathway Chemotaxis Response To External Stimulus Dendritic Cell Chemotaxis Dendritic Cell Migration Locomotion Cell Chemotaxis Retrograde Vesicle-mediated Transport, Golgi To ER Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Receptor Internalization Movement Of Cell Or Subcellular Component Vesicle Docking Involved In Exocytosis Negative Regulation Of Neutrophil Apoptotic Process Basolateral Protein Localization Chemokine-mediated Signaling Pathway Golgi Vesicle Transport Vesicle Docking Neutrophil Mediated Killing Of Gram-positive Bacterium Receptor Metabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Membrane Docking Post-Golgi Vesicle-mediated Transport Negative Regulation Of Dendritic Spine Morphogenesis Negative Regulation Of Autophagic Vacuole Assembly Establishment Of Neuroblast Polarity Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Defense Response Leukocyte Chemotaxis Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Endopeptidase Activity Cell Migration Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Membrane Organization Regulation Of Peptidase Activity Vesicle-mediated Transport Immune System Process Negative Regulation Of Mitochondrial Membrane Potential Aortic Valve Morphogenesis Endocardial Cushion To Mesenchymal Transition Notochord Formation Cell Motility Regulation Of Protein Metabolic Process Protein Localization To Endoplasmic Reticulum Intracellular Transport Acute Inflammatory Response To Antigenic Stimulus Negative Regulation Of Dendritic Spine Development Mitral Valve Morphogenesis Mitral Valve Development	Tail-anchored Membrane Protein Insertion Into ER Membrane Protein Insertion Into ER Membrane Leukocyte Migration Involved In Inflammatory Response Protein Insertion Into Membrane Synaptonemal Complex Assembly Synaptonemal Complex Organization Hexose Transmembrane Transport Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Endoplasmic Reticulum Organization Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Cell Proliferation Synapsis Homologous Chromosome Segregation Carbohydrate Transmembrane Transport Chemokine-mediated Signaling Pathway Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Leukocyte Chemotaxis Platelet Degranulation Glucose Transport Negative Regulation Of Cellular Protein Catabolic Process Hexose Transport Meiotic Chromosome Segregation Positive Regulation Of Leukocyte Migration Protein Stabilization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Immune System Process Meiosis I Positive Regulation Of Chemotaxis Signal Transduction By P53 Class Mediator Regulation Of Leukocyte Migration Negative Regulation Of Protein Catabolic Process Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Carbohydrate Transport Cellular Localization Positive Regulation Of Behavior Positive Regulation Of Cell Division Protein Acetylation Regulation Of Protein Stability Regulation Of Chemotaxis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		10q 4q another chemokine constitutes cr cxc divergent evolutionary gcp2 genbridge gro1 gro2 gro3 il8 inp10 mapped mentioned mig pair panel pf4 pf4v1 phylogenetic physically primers scyb5 sdf1 separated
Tagcloud (Difference) ?		10q 4q another chemokine constitutes cr cxc divergent evolutionary gcp2 genbridge gro1 gro2 gro3 il8 inp10 mapped mentioned mig pair panel pf4 pf4v1 phylogenetic physically primers scyb5 sdf1 separated
Tagcloud (Intersection) ?