LRRC4C and TWSG1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LRRC4C	TWSG1
Description		leucine rich repeat containing 4C	twisted gastrulation BMP signaling modulator 1
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GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane Synapse Postsynaptic Membrane Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding Cell Adhesion Molecule Binding Cell-cell Adhesion Mediator Activity	Protein Binding Heparin Binding Transforming Growth Factor Beta Binding
	Biological Process	Regulation Of Axonogenesis Modulation Of Chemical Synaptic Transmission Synaptic Membrane Adhesion	Ossification Mesoderm Formation Negative Regulation Of Cytokine Production Chondrocyte Differentiation Salivary Gland Morphogenesis Tissue Development Hemopoiesis BMP Signaling Pathway Regulation Of BMP Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Forebrain Development Camera-type Eye Development Negative Regulation Of Osteoblast Differentiation Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of CD4-positive, Alpha-beta T Cell Activation Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Cerebellum cortex volume ( 31530798) Cerebrospinal fluid beta-site APP cleaving enzyme levels ( 29751835) Cerebrospinal fluid p-tau levels ( 29274321) Diastolic blood pressure response to thiazide and thiazide-like diuretics in hypertension ( 31754133) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Femur bone mineral density x serum urate levels interaction ( 34046847) General risk tolerance (MTAG) ( 30643258) High myopia ( 31816047) Iris color (L* coordinate) ( 30895295) Low myopia ( 33830181) Low myopia vs hyperopia ( 33830181) Mastocytosis (KIT D816V positive) ( 33421400) Mosquito bite size ( 28199695) Myopia ( 27182965) Order dimension in obsessive compulsive disorder ( 32424139) Osteoporosis-related phenotypes ( 20548944) Pediatric central nervous system tumors (early onset)(pleiotropy) ( 33226468) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Survival in colorectal cancer ( 26586795) Temperament (bipolar disorder) ( 22365631)	Dental caries ( 23064961)
Interacting Genes		27 interacting genes: AGTRAP BDKRB1 BMP10 BRICD5 CLDN19 CLEC1A CLEC4G CMTM5 CREB3L4 DRAM1 EMP3 GJB2 LEPROTL1 LHFPL5 MIP NTNG1 PGAP2 PLP2 SERTM1 SMIM1 SNAP47 STX5 TWSG1 VEZT VSTM1 WHRN YIPF6	10 interacting genes: BMP1 BMP4 CHRD FAM209A FNDC9 GJA8 GPRC5D LRRC4C SGTA TNS2
Entrez ID		57689	57045
HPRD ID		12303	05443
Ensembl ID		ENSG00000148948	ENSG00000128791
Uniprot IDs		Q4JIV9 Q4JIW0 Q9HCJ2	Q9GZX9
PDB IDs		3ZYJ	8BWA 8BWD 8BWI 8BWL 8BWM 8BWN
Enriched GO Terms of Interacting Partners?		Membrane Gap Junction-mediated Intercellular Transport Stereocilia Ankle Link Complex Plasma Membrane Intercellular Transport Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Stereocilium Bundle Stereocilium Tip Negative Regulation Of Alpha-beta T Cell Proliferation Auditory Receptor Cell Stereocilium Organization	Dorsal/ventral Pattern Formation Positive Regulation Of Cartilage Development Skeletal System Development Regionalization Negative Regulation Of Metanephric Comma-shaped Body Morphogenesis Bud Dilation Involved In Lung Branching Apoptotic Process Involved In Endocardial Cushion Morphogenesis Negative Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Intermediate Mesodermal Cell Differentiation Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Metanephric S-shaped Body Morphogenesis Positive Regulation Of Cardiac Muscle Fiber Development Negative Regulation Of Glomerulus Development Negative Regulation Of BMP Signaling Pathway Regulation Of Cartilage Development Positive Regulation Of Primary MiRNA Processing Tendon Cell Differentiation Negative Regulation Of Branching Involved In Ureteric Bud Morphogenesis Camera-type Eye Development BMP Signaling Pathway Positive Regulation Of Branching Involved In Lung Morphogenesis TRC Complex Pattern Specification Process Growth Factor Activity Cartilage Development Ossification Apoptotic Process Involved In Heart Morphogenesis Regulation Of Osteoblast Differentiation Positive Regulation Of MiRNA Processing Negative Regulation Of Glomerular Mesangial Cell Proliferation Nephric Duct Formation Bronchus Development Positive Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Deltoid Tuberosity Development Epithelial Cell Proliferation Involved In Lung Morphogenesis Cardiac Jelly Development Eye Development Negative Regulation Of Immature T Cell Proliferation Prostate Gland Morphogenesis Epithelial-mesenchymal Cell Signaling Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Branching Involved In Lung Morphogenesis Telencephalon Regionalization Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Branching Involved In Prostate Gland Morphogenesis Glomerular Capillary Formation Pericyte Cell Differentiation Specification Of Animal Organ Position Regulation Of BMP Signaling Pathway Trachea Development
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