BDKRB1 and MEP1A

Number of citations of the paper that reports this interaction (PMID 11278902)
30

Data Source:
BioGRID (enzymatic study)

		BDKRB1	MEP1A
Gene Name		bradykinin receptor B1	meprin A, alpha (PABA peptide hydrolase)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection	Extracellular Space Integral Component Of Plasma Membrane Meprin A Complex Extracellular Vesicular Exosome
	Molecular Function	Bradykinin Receptor Activity Protein Binding Peptide Binding	Metalloendopeptidase Activity Protein Binding Zinc Ion Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Positive Regulation Of Leukocyte Migration Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Response To Mechanical Stimulus Cell Migration Sensory Perception Of Pain Negative Regulation Of Cell Growth Response To Lipopolysaccharide Negative Regulation Of Blood Pressure Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol	Proteolysis Digestion
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: GNAQ MEP1A	19 interactors: AGT BDKRB1 CCK FN1 GCG GNRH1 GRP KNG1 LAMA1 LAMA5 MEP1B NPY NTS PLG POMC PTH SCT TAC1 VIP
Entrez ID		623	4224
HPRD ID		02639	02666
Ensembl ID		ENSG00000100739	ENSG00000112818
Uniprot IDs		G3V4Y2 P46663	B7ZL91 Q16819
PDB IDs
Enriched GO Terms of Interacting Partners?		Phospholipase C-activating Dopamine Receptor Signaling Pathway Neuron Remodeling Regulation Of Melanocyte Differentiation Maternal Behavior Regulation Of Catenin Import Into Nucleus Regulation Of Developmental Pigmentation Neuron Maturation Dopamine Receptor Signaling Pathway Forebrain Neuron Development Activation Of Phospholipase C Activity Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phospholipase C Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Forebrain Neuron Differentiation Glutamate Receptor Signaling Pathway Developmental Pigmentation Embryonic Digit Morphogenesis Positive Regulation Of Phospholipase Activity Forebrain Generation Of Neurons Regulation Of Phospholipase Activity Action Potential Positive Regulation Of Lipase Activity Protein Stabilization Central Nervous System Neuron Development Pigmentation Digestion Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Protein Stability Regulation Of Epithelial Cell Differentiation Post-embryonic Development Cell Maturation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Embryonic Limb Morphogenesis Regulation Of Protein Import Into Nucleus Limb Morphogenesis Platelet Activation Regulation Of Protein Localization To Nucleus Limb Development Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Protein Kinase Activity Central Nervous System Neuron Differentiation	Response To Stimulus Blood Circulation G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Renal Sodium Excretion Regulation Of Ion Homeostasis Behavior Regulation Of Blood Pressure Cell Surface Receptor Signaling Pathway Regulation Of Renal Sodium Excretion Regulation Of Appetite Neuropeptide Signaling Pathway Regulation Of Excretion Feeding Behavior Signal Transduction Regulation Of Corticosterone Secretion Cell-cell Signaling Response To External Stimulus Regulation Of Cell Migration Signaling Regulation Of Cell Motility Secretion Cell Communication Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Locomotion Regulation Of Cellular Component Movement Cellular Homeostasis Regulation Of Neurological System Process Cellular Metal Ion Homeostasis Positive Regulation Of Transport Inflammatory Response Positive Regulation Of CAMP Biosynthetic Process Response To Nutrient Levels Cellular Cation Homeostasis Positive Regulation Of CAMP Metabolic Process Cellular Ion Homeostasis Single-organism Behavior Platelet Degranulation Response To Extracellular Stimulus Metal Ion Homeostasis Regulation Of Blood Vessel Size Regulation Of Tube Size Secretion By Cell Chemical Homeostasis Cellular Response To Stimulus Blood Vessel Development Regulation Of Cellular Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process
Tagcloud ?		14q32 assaying blot cat cloned close coding copy encoded enhancer exon flanking fragment kb lengths linking northern oligonucleotide pancreas probes proximity q32 reporter sequenced southern transcript uninterrupted widespread	accumulating anthropometric borderline carriers disturbances exonuclease fertility fluorogenic genbank gg gt hirsutism homa homeostatic hormonal hyperandrogenemia id obese ovary overweight pcos polycystic prominent rs17468190 taqman triglyceride tt utr variants
Tagcloud (Difference) ?		14q32 assaying blot cat cloned close coding copy encoded enhancer exon flanking fragment kb lengths linking northern oligonucleotide pancreas probes proximity q32 reporter sequenced southern transcript uninterrupted widespread	accumulating anthropometric borderline carriers disturbances exonuclease fertility fluorogenic genbank gg gt hirsutism homa homeostatic hormonal hyperandrogenemia id obese ovary overweight pcos polycystic prominent rs17468190 taqman triglyceride tt utr variants
Tagcloud (Intersection) ?