MORF4L2 and KLHL3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		MORF4L2	KLHL3
Gene Name		mortality factor 4 like 2	kelch-like family member 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus	Cytosol Cytoskeleton Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding	Actin Binding Structural Molecule Activity Protein Binding
	Biological Process	DNA Repair Chromatin Organization Transcription, DNA-templated Chromatin Modification Regulation Of Growth Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Striated Muscle Cell Differentiation	Protein Ubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Ion Homeostasis Renal Sodium Ion Absorption Protein K48-linked Ubiquitination Distal Tubule Morphogenesis
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		28 interactors: AES BEND7 CDR2 CEP55 DDIT4L FAM9B GOLGA2 GRAMD3 HDAC1 IKZF1 KLHL3 L3MBTL3 LZTS2 MRFAP1 MRFAP1L1 MRGBP PHC2 PNMA2 RB1 SIN3A THAP1 TLE1 TNIP1 TNNT2 ZBTB10 ZBTB14 ZBTB43 ZBTB7B	12 interactors: C6orf165 CUL3 GNAI1 GNAO1 KEAP1 KLHL12 MORF4L2 OPRD1 SYNCRIP SYT2 WNK3 WNK4
Entrez ID		9643	26249
HPRD ID		02326	09011
Ensembl ID		ENSG00000123562	ENSG00000146021
Uniprot IDs		Q15014	Q9UH77
PDB IDs			4HXI
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Biosynthetic Process Chromatin Modification Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Chromatin Organization Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Signaling Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Binding Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Anoikis Organ Development Cell Cycle Chromosome Organization Nitrogen Compound Metabolic Process Multicellular Organismal Development Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Mitotic Cell Cycle Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Neutrophil Differentiation Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Response To Methylglyoxal Negative Regulation Of Histone H3-K27 Acetylation Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Cell Cycle Phase Transition Developmental Process Negative Regulation Of Protein Binding Histone Deacetylation	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cellular Response To Stimulus COPII Vesicle Coating G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger COPII-coated Vesicle Budding Regulation Of Calcium Ion Transport Vesicle Targeting, To, From Or Within Golgi Vesicle Organization Protein Monoubiquitination Localization Within Membrane Vesicle Targeting Response To Stimulus Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Rubidium Ion Transport Positive Regulation Of Rubidium Ion Transmembrane Transporter Activity Positive Regulation Of Proteasomal Protein Catabolic Process Membrane Budding ER To Golgi Vesicle-mediated Transport Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Distal Tubule Morphogenesis Trophectodermal Cellular Morphogenesis Positive Regulation Of Protein Metabolic Process Renal Sodium Ion Absorption Proteasomal Ubiquitin-independent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Pancreatic Juice Secretion Renal Sodium Ion Transport CRD-mediated MRNA Stabilization Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Regulation Of Rubidium Ion Transport Protein Modification By Small Protein Conjugation Regulation Of Ion Transport Cytoplasmic Transport Signal Transduction Response To Organic Substance Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Wnt Signaling Pathway Response To Cytokine Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Establishment Of Vesicle Localization Vesicle Localization
Tagcloud ?			aii cotransporter cul3 cullin depletion directing hyperkalemia hypertension impair inverse kelch ligase maximize maximized missense nacl obligatory obscure phenocopy physiologic posited prevents reabsorption s433 salt volume wnk1 wnk4 wnks
Tagcloud (Difference) ?			aii cotransporter cul3 cullin depletion directing hyperkalemia hypertension impair inverse kelch ligase maximize maximized missense nacl obligatory obscure phenocopy physiologic posited prevents reabsorption s433 salt volume wnk1 wnk4 wnks
Tagcloud (Intersection) ?