MORF4L2 and GLA

Data Source: HiPPIP (Novel)

		MORF4L2	GLA
Name		mortality factor 4 like 2	galactosidase alpha
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleosome Nucleus Nucleoplasm Nucleolus Plasma Membrane NuA4 Histone Acetyltransferase Complex	Extracellular Region Cytoplasm Lysosome Golgi Apparatus Membrane Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	Protein Binding	Catalytic Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Alpha-galactosidase Activity Signaling Receptor Binding Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Protein Homodimerization Activity
	Biological Process	DNA Repair Chromatin Organization Regulation Of DNA-templated Transcription DNA Damage Response Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair	Carbohydrate Metabolic Process Lipid Metabolic Process Oligosaccharide Metabolic Process Glycoside Catabolic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Glycosylceramide Catabolic Process Glycosphingolipid Catabolic Process Negative Regulation Of Nitric-oxide Synthase Activity
Pathways		HATs acetylate histones	Neutrophil degranulation Glycosphingolipid catabolism
Drugs		None	Migalastat
Diseases		None	Fabry disease
GWAS		Lymphocyte percentage of white cells ( 32888494 ) Mean platelet volume ( 32888494 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: GLA	12 novel interactors: ANKRD30A CCR2 COL4A5 DUSP6 GPR17 GUCY2F HNRNPH2 MORF4L2 NAP1L3 NOSTRIN PDE6B PLP1
Interacting Genes		54 interacting genes: AMOTL2 ARID3A BCL11A BEND7 BEX5 CAMK2B CDR2 CEP55 DDIT4L DISC1 DSCAM EVI5 FAM9B FBXO16 GOLGA2 GPBP1 GRAMD2B HDAC1 HMBOX1 HOMEZ HUNK IKZF1 KCTD1 KLHL3 L3MBTL3 LUZP4 LZTS2 MEOX2 MRFAP1 MRGBP MRPL12 NAB2 PHC2 PIBF1 PICK1 PNMA2 POU6F2 RB1 REL SIN3A SYN3 THAP1 TLE1 TLE5 TNIP1 TNNT2 TRIM41 TSN ZBTB10 ZBTB14 ZBTB26 ZBTB43 ZBTB7B ZNF48	3 interacting genes: OGT TERT UBC
Entrez ID		9643	2717
HPRD ID		02326	02357
Ensembl ID		ENSG00000123562	ENSG00000102393
Uniprot IDs		Q15014	A0A3B3IUC4 A0A6Q8PHD1 P06280 Q53Y83
PDB IDs		Not available	1R46 1R47 3GXN 3GXP 3GXT 3HG2 3HG3 3HG4 3HG5 3LX9 3LXA 3LXB 3LXC 3S5Y 3S5Z 3TV8 4NXS 6IBK 6IBM 6IBR 6IBT 8K7D 8K7E 8K7F 8K7G 8K7H 8K7I 8K7J 8K7K 8K7L 9AVS
GO Terms Enriched among Interactors		Identical Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Protein Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Transcription Corepressor Activity Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleus Nucleoplasm Regulation Of Axon Extension RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Importin-alpha Family Protein Binding Positive Regulation Of Cell Development Positive Regulation Of Neurogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Neurogenesis	None