NR1H2 and DUSP12

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		NR1H2	DUSP12
Gene Name		nuclear receptor subfamily 1, group H, member 2	dual specificity phosphatase 12
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific Transcription Regulatory Region DNA Binding RNA Polymerase II Transcription Factor Recruiting Transcription Factor Activity DNA Binding Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Zinc Ion Binding Apolipoprotein A-I Receptor Binding Retinoid X Receptor Binding ATPase Binding	Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Zinc Ion Binding Kinase Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Positive Regulation Of Lipid Storage Negative Regulation Of Cholesterol Storage Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Lipid Transport Positive Regulation Of Cholesterol Transport Cholesterol Homeostasis Steroid Hormone Mediated Signaling Pathway Cellular Lipid Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Pinocytosis Positive Regulation Of Lipoprotein Lipase Activity Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of Pancreatic Juice Secretion Positive Regulation Of Secretion Of Lysosomal Enzymes Regulation Of Cholesterol Homeostasis	Cellular Protein Modification Process Protein Dephosphorylation Positive Regulation Of Glucokinase Activity Peptidyl-tyrosine Dephosphorylation
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs		(3-{3-[[2-Chloro-3-(Trifluoromethyl)Benzyl](2,2-Diphenylethyl)Amino]Propoxy}Phenyl)Acetic Acid Benzenesulfonyl N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE 1,1,1,3,3,3-HEXAFLUORO-2-{4-[(2,2,2-TRIFLUOROETHYL)AMINO]PHENYL}PROPAN-2-OL
Diseases
GWAS
Protein-Protein Interactions		46 interactors: BAG6 C14orf1 CDKN1A CHD3 COL4A5 CSAD DUSP12 FAF1 FOXO3 HDAC4 HMGXB4 ING3 KDM1A LAMC3 MDFI MED1 MPP1 NCOA3 NCOA6 NCOR1 NCOR2 NPY NR0B2 NRIP1 PCDH17 PRKCA RARA RMI1 ROBO2 RXRA RXRB RXRG SCG5 SIRT1 SMPD1 SORBS2 SPRY2 SRC SUV39H1 TMEM161A UBE2D1 UBE2I VDR VIM YY1 ZXDC	12 interactors: APP CALCOCO2 CCNH EIF5 HSPB8 KIAA1377 MBD6 NR1H2 PPP2R3B PTN RABAC1 USO1
Entrez ID		7376	11266
HPRD ID		02660	05323
Ensembl ID		ENSG00000131408	ENSG00000081721
Uniprot IDs		B4DNM6 F1D8P7 M0R2F9 P55055	Q9UNI6
PDB IDs		1P8D 1PQ6 1PQ9 1PQC 1UPV 1UPW 3KFC 3L0E 4DK7 4DK8
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process DNA-templated Transcription, Initiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Response To Organic Substance Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Reproductive Structure Development Reproductive System Development System Development Positive Regulation Of Gene Expression Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Response To Hormone Multicellular Organismal Development Cell Differentiation Single Organism Reproductive Process Anatomical Structure Development Developmental Process Involved In Reproduction Developmental Process Reproductive Process Cellular Response To Steroid Hormone Stimulus Signal Transduction Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Cellular Response To Organic Substance Cellular Response To Stimulus Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of RNA Biosynthetic Process Chromatin Organization Response To Stimulus Hormone-mediated Signaling Pathway Regulation Of RNA Metabolic Process Gene Expression Positive Regulation Of Transcription, DNA-templated Signaling	Mitotic Cell Cycle Positive Regulation Of Secretion Of Lysosomal Enzymes Positive Regulation Of Pancreatic Juice Secretion Positive Regulation Of High-density Lipoprotein Particle Assembly Synaptic Growth At Neuromuscular Junction Golgi Vesicle Docking Collateral Sprouting In Absence Of Injury Regulation Of High-density Lipoprotein Particle Assembly Learning Regulation Of Catalytic Activity Cell Cycle Negative Regulation Of Pinocytosis G1/S Transition Of Mitotic Cell Cycle Collateral Sprouting Axon Midline Choice Point Recognition Transcription Initiation From RNA Polymerase II Promoter Mitotic Cell Cycle Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Axon Choice Point Recognition Intracellular Receptor Signaling Pathway Negative Regulation Of Cholesterol Storage Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Vesicle Fusion With Golgi Apparatus Positive Regulation Of Digestive System Process DNA-templated Transcription, Initiation Neuron Remodeling
Tagcloud ?			bmp cacna1d ccl2 cd25 cd26 cdkn1a cml cure dpp4 dysregulation eradication exploited il1rap il2ra kcnk5 lscs marcks microarrays mycn oncogenes perp persistence ptprd refined slc4a4 timeless tki transcriptome withdrawal
Tagcloud (Difference) ?			bmp cacna1d ccl2 cd25 cd26 cdkn1a cml cure dpp4 dysregulation eradication exploited il1rap il2ra kcnk5 lscs marcks microarrays mycn oncogenes perp persistence ptprd refined slc4a4 timeless tki transcriptome withdrawal
Tagcloud (Intersection) ?