NR1H2 and ING3

Number of citations of the paper that reports this interaction (PubMedID 15604093)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NR1H2	ING3
Description		nuclear receptor subfamily 1 group H member 2	inhibitor of growth family member 3
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol RNA Polymerase II Transcription Regulator Complex	Nucleosome Swr1 Complex Nucleus Nucleoplasm Piccolo Histone Acetyltransferase Complex NuA4 Histone Acetyltransferase Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Chromatin DNA Binding Apolipoprotein A-I Receptor Binding Sequence-specific DNA Binding Metal Ion Binding Nuclear Retinoid X Receptor Binding ATPase Binding	Zinc Ion Binding Histone H4 Acetyltransferase Activity Histone H4K5 Acetyltransferase Activity Histone H4K8 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Histone H2A Acetyltransferase Activity Metal Ion Binding Histone H4K16 Acetyltransferase Activity Histone H3K4me3 Reader Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Hormone-mediated Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Regulation Of Lipid Storage Positive Regulation Of Lipid Storage Negative Regulation Of Cholesterol Storage Cell Differentiation Intracellular Receptor Signaling Pathway Response To Nutrient Levels Negative Regulation Of Lipid Transport Positive Regulation Of Cholesterol Transport Phosphatidylcholine Acyl-chain Remodeling Cholesterol Homeostasis MRNA Transcription By RNA Polymerase II Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Proteolysis Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Pinocytosis Negative Regulation Of Inflammatory Response Lipid Homeostasis Negative Regulation Of Type II Interferon-mediated Signaling Pathway Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of Pancreatic Juice Secretion Positive Regulation Of Secretion Of Lysosomal Enzymes Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of MiRNA Transcription Negative Regulation Of Response To Endoplasmic Reticulum Stress	Chromatin Organization Chromatin Remodeling Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair
Pathways		PPARA activates gene expression Nuclear Receptor transcription pathway SUMOylation of intracellular receptors VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	HATs acetylate histones
Drugs		GW-3965 Benzenesulfinic acid TO-901317 1,1,1,3,3,3-HEXAFLUORO-2-{4-[(2,2,2-TRIFLUOROETHYL)AMINO]PHENYL}PROPAN-2-OL Diacerein Rhein
Diseases
GWAS
Interacting Genes		52 interacting genes: BAG6 CDKN1A CHD3 COL4A5 CSAD DNMT3L DUSP12 ERG28 FAF1 FOXO3 HDAC4 HMGXB4 ING3 KDM1A LAMC3 MDFI MED1 MPP1 NCOA1 NCOA3 NCOA6 NCOR1 NCOR2 NPY NR0B2 NRIP1 PCDH17 PPARA PPARD PPARG PRKCA RARA RHOU RMI1 ROBO2 RXRA RXRB RXRG SCG5 SIRT1 SMPD1 SORBS2 SPRY2 SUV39H1 TMEM161A TTC3 UBE2D1 UBE2I VDR VIM YY1 ZXDC	9 interacting genes: APP BEX5 FBXO25 NR1H2 NR1H3 SIVA1 TEX11 TRIM54 USHBP1
Entrez ID		7376	54556
HPRD ID		02660	06321
Ensembl ID		ENSG00000131408	ENSG00000071243
Uniprot IDs		F1D8P7 P55055	B7ZKQ7 Q9NXR8
PDB IDs		1P8D 1PQ6 1PQ9 1PQC 1UPV 1UPW 3KFC 3L0E 4DK7 4DK8 4NQA 4RAK 5HJP 5I4V 5JY3 5KYA 5KYJ 6JIO 6K9G 6K9H 6K9M 6S4N 6S4T 6S4U 6S5K	1X4I 7ZMX
Enriched GO Terms of Interacting Partners?		Nuclear Receptor-mediated Signaling Pathway Nuclear Retinoid X Receptor Binding Negative Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Hormone-mediated Signaling Pathway Nuclear Receptor Binding Chromatin Negative Regulation Of MiRNA Transcription Nuclear Receptor Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Nuclear Steroid Receptor Activity Regulation Of MiRNA Transcription Intracellular Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Transcription By RNA Polymerase II Peroxisome Proliferator Activated Receptor Signaling Pathway RNA Polymerase II Transcription Regulator Complex Regulation Of Primary Metabolic Process Regulation Of MiRNA Metabolic Process Regulation Of RNA Metabolic Process Nucleoplasm MRNA Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Response To Nutrient Levels Response To Lipid Nuclear Retinoic Acid Receptor Binding Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Retinoic Acid-responsive Element Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Rhythmic Process Transcription Cis-regulatory Region Binding Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process	Negative Regulation Of Type II Interferon-mediated Signaling Pathway Negative Regulation Of Pinocytosis Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Response To Type II Interferon Negative Regulation Of Cholesterol Storage Negative Regulation Of Macrophage Derived Foam Cell Differentiation Phosphatidylcholine Acyl-chain Remodeling Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of Lipid Storage Positive Regulation Of Triglyceride Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Cholesterol Efflux Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Transport Negative Regulation Of Lipid Transport Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Triglyceride Metabolic Process Regulation Of Lipid Storage Regulation Of Fatty Acid Biosynthetic Process MRNA Transcription By RNA Polymerase II Regulation Of Cholesterol Efflux Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Response To Endoplasmic Reticulum Stress Nuclear Receptor Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway MRNA Transcription Positive Regulation Of Secretion Of Lysosomal Enzymes Negative Regulation Of Secretion Of Lysosomal Enzymes CD27 Receptor Binding Meiotic Gene Conversion Putamen Development Caudate Nucleus Development Phosphatidylcholine Metabolic Process Regulation Of Endocytosis Regulation Of Cholesterol Transport Negative Regulation Of Endocytosis Regulation Of Small Molecule Metabolic Process Regulation Of MiRNA Transcription Positive Regulation Of Transport Acetylcholine Receptor Activator Activity Regulation Of MiRNA Metabolic Process Metal Ion Binding Regulation Of Proteolysis
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