NR1H2 and TMEM161A

Number of citations of the paper that reports this interaction (PMID 15604093)
36

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NR1H2	TMEM161A
Gene Name		nuclear receptor subfamily 1, group H, member 2	transmembrane protein 161A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Integral Component Of Membrane
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific Transcription Regulatory Region DNA Binding RNA Polymerase II Transcription Factor Recruiting Transcription Factor Activity DNA Binding Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Zinc Ion Binding Apolipoprotein A-I Receptor Binding Retinoid X Receptor Binding ATPase Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Positive Regulation Of Lipid Storage Negative Regulation Of Cholesterol Storage Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Lipid Transport Positive Regulation Of Cholesterol Transport Cholesterol Homeostasis Steroid Hormone Mediated Signaling Pathway Cellular Lipid Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Pinocytosis Positive Regulation Of Lipoprotein Lipase Activity Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of Pancreatic Juice Secretion Positive Regulation Of Secretion Of Lysosomal Enzymes Regulation Of Cholesterol Homeostasis	Response To Retinoic Acid Cellular Response To Oxidative Stress Cellular Response To UV Positive Regulation Of DNA Repair Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs		(3-{3-[[2-Chloro-3-(Trifluoromethyl)Benzyl](2,2-Diphenylethyl)Amino]Propoxy}Phenyl)Acetic Acid Benzenesulfonyl N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE 1,1,1,3,3,3-HEXAFLUORO-2-{4-[(2,2,2-TRIFLUOROETHYL)AMINO]PHENYL}PROPAN-2-OL
Diseases
GWAS
Protein-Protein Interactions		46 interactors: BAG6 C14orf1 CDKN1A CHD3 COL4A5 CSAD DUSP12 FAF1 FOXO3 HDAC4 HMGXB4 ING3 KDM1A LAMC3 MDFI MED1 MPP1 NCOA3 NCOA6 NCOR1 NCOR2 NPY NR0B2 NRIP1 PCDH17 PRKCA RARA RMI1 ROBO2 RXRA RXRB RXRG SCG5 SIRT1 SMPD1 SORBS2 SPRY2 SRC SUV39H1 TMEM161A UBE2D1 UBE2I VDR VIM YY1 ZXDC	2 interactors: NR1H2 NR1H3
Entrez ID		7376	54929
HPRD ID		02660	07905
Ensembl ID		ENSG00000131408	ENSG00000064545
Uniprot IDs		B4DNM6 F1D8P7 M0R2F9 P55055	Q9NX61
PDB IDs		1P8D 1PQ6 1PQ9 1PQC 1UPV 1UPW 3KFC 3L0E 4DK7 4DK8
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process DNA-templated Transcription, Initiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Response To Organic Substance Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Reproductive Structure Development Reproductive System Development System Development Positive Regulation Of Gene Expression Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Response To Hormone Multicellular Organismal Development Cell Differentiation Single Organism Reproductive Process Anatomical Structure Development Developmental Process Involved In Reproduction Developmental Process Reproductive Process Cellular Response To Steroid Hormone Stimulus Signal Transduction Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Cellular Response To Organic Substance Cellular Response To Stimulus Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of RNA Biosynthetic Process Chromatin Organization Response To Stimulus Hormone-mediated Signaling Pathway Regulation Of RNA Metabolic Process Gene Expression Positive Regulation Of Transcription, DNA-templated Signaling	Negative Regulation Of Pinocytosis Negative Regulation Of Cholesterol Storage Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Cholesterol Homeostasis Positive Regulation Of Cholesterol Efflux Positive Regulation Of Lipoprotein Lipase Activity Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Transport Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Regulation Of Cholesterol Efflux Regulation Of Triglyceride Biosynthetic Process Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Negative Regulation Of Lipid Transport Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Regulation Of Cholesterol Transport Regulation Of Triglyceride Metabolic Process Negative Regulation Of Innate Immune Response Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Endocytosis Regulation Of Lipid Storage Positive Regulation Of Lipid Transport Positive Regulation Of Lipid Biosynthetic Process Cholesterol Homeostasis Sterol Homeostasis Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Lipase Activity Regulation Of Lipid Transport Steroid Hormone Mediated Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Lipid Homeostasis Negative Regulation Of Immune Response Hormone-mediated Signaling Pathway Regulation Of Lipid Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Regulation Of Endocytosis Intracellular Receptor Signaling Pathway Positive Regulation Of Secretion Of Lysosomal Enzymes Negative Regulation Of Secretion Of Lysosomal Enzymes Positive Regulation Of Pancreatic Juice Secretion Positive Regulation Of High-density Lipoprotein Particle Assembly DNA-templated Transcription, Initiation Regulation Of Innate Immune Response Regulation Of Lipid Metabolic Process
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