NR1H2 and TMEM161A

Number of citations of the paper that reports this interaction (PubMedID 15604093)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NR1H2	TMEM161A
Description		nuclear receptor subfamily 1 group H member 2	transmembrane protein 161A
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol RNA Polymerase II Transcription Regulator Complex	Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Chromatin DNA Binding Apolipoprotein A-I Receptor Binding Sequence-specific DNA Binding Metal Ion Binding Nuclear Retinoid X Receptor Binding ATPase Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Hormone-mediated Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Regulation Of Lipid Storage Positive Regulation Of Lipid Storage Negative Regulation Of Cholesterol Storage Cell Differentiation Intracellular Receptor Signaling Pathway Response To Nutrient Levels Negative Regulation Of Lipid Transport Positive Regulation Of Cholesterol Transport Phosphatidylcholine Acyl-chain Remodeling Cholesterol Homeostasis MRNA Transcription By RNA Polymerase II Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Proteolysis Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Pinocytosis Negative Regulation Of Inflammatory Response Lipid Homeostasis Negative Regulation Of Type II Interferon-mediated Signaling Pathway Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of Pancreatic Juice Secretion Positive Regulation Of Secretion Of Lysosomal Enzymes Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of MiRNA Transcription Negative Regulation Of Response To Endoplasmic Reticulum Stress	Response To Retinoic Acid Cellular Response To Oxidative Stress Cellular Response To UV Positive Regulation Of DNA Repair Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways		PPARA activates gene expression Nuclear Receptor transcription pathway SUMOylation of intracellular receptors VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
Drugs		GW-3965 Benzenesulfinic acid TO-901317 1,1,1,3,3,3-HEXAFLUORO-2-{4-[(2,2,2-TRIFLUOROETHYL)AMINO]PHENYL}PROPAN-2-OL Diacerein Rhein
Diseases
GWAS
Interacting Genes		52 interacting genes: BAG6 CDKN1A CHD3 COL4A5 CSAD DNMT3L DUSP12 ERG28 FAF1 FOXO3 HDAC4 HMGXB4 ING3 KDM1A LAMC3 MDFI MED1 MPP1 NCOA1 NCOA3 NCOA6 NCOR1 NCOR2 NPY NR0B2 NRIP1 PCDH17 PPARA PPARD PPARG PRKCA RARA RHOU RMI1 ROBO2 RXRA RXRB RXRG SCG5 SIRT1 SMPD1 SORBS2 SPRY2 SUV39H1 TMEM161A TTC3 UBE2D1 UBE2I VDR VIM YY1 ZXDC	12 interacting genes: AGTR1 CCR2 CHRM5 F2RL1 GNRHR GPR35 GPR37 NR1H2 NR1H3 OXTR PTGER4 SLC22A2
Entrez ID		7376	54929
HPRD ID		02660	07905
Ensembl ID		ENSG00000131408	ENSG00000064545
Uniprot IDs		F1D8P7 P55055	K7EPA3 Q9NX61
PDB IDs		1P8D 1PQ6 1PQ9 1PQC 1UPV 1UPW 3KFC 3L0E 4DK7 4DK8 4NQA 4RAK 5HJP 5I4V 5JY3 5KYA 5KYJ 6JIO 6K9G 6K9H 6K9M 6S4N 6S4T 6S4U 6S5K
Enriched GO Terms of Interacting Partners?		Nuclear Receptor-mediated Signaling Pathway Nuclear Retinoid X Receptor Binding Negative Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Hormone-mediated Signaling Pathway Nuclear Receptor Binding Chromatin Negative Regulation Of MiRNA Transcription Nuclear Receptor Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Nuclear Steroid Receptor Activity Regulation Of MiRNA Transcription Intracellular Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Transcription By RNA Polymerase II Peroxisome Proliferator Activated Receptor Signaling Pathway RNA Polymerase II Transcription Regulator Complex Regulation Of Primary Metabolic Process Regulation Of MiRNA Metabolic Process Regulation Of RNA Metabolic Process Nucleoplasm MRNA Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Response To Nutrient Levels Response To Lipid Nuclear Retinoic Acid Receptor Binding Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Retinoic Acid-responsive Element Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Rhythmic Process Transcription Cis-regulatory Region Binding Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process	G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Biological Quality Regulation Of Body Fluid Levels Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Cold-induced Thermogenesis Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Pinocytosis Signal Transduction Regulation Of Inflammatory Response Negative Regulation Of Transport Negative Regulation Of Type II Interferon-mediated Signaling Pathway Positive Regulation Of Defense Response Regulation Of Defense Response Negative Regulation Of Cholesterol Storage Vascular Process In Circulatory System Regulation Of System Process Regulation Of Secretion By Cell Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Immune System Process Negative Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Response To Type II Interferon Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Response To Cytokine Stimulus Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Phosphatidylcholine Acyl-chain Remodeling Regulation Of Secretion Circulatory System Process Regulation Of Lipid Metabolic Process Regulation Of Triglyceride Biosynthetic Process Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Dopamine Transport Negative Regulation Of Lipid Storage Positive Regulation Of Triglyceride Metabolic Process Chemokine Receptor Activity Positive Regulation Of Fatty Acid Biosynthetic Process Regulation Of Lipid Transport Positive Regulation Of Lipid Metabolic Process Apoptotic Cell Clearance Positive Regulation Of Metabolic Process Negative Regulation Of Secretion By Cell Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Blood Vessel Diameter Maintenance Regulation Of Tube Size Plasma Membrane Positive Regulation Of Cholesterol Efflux Positive Regulation Of Small Molecule Metabolic Process
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