TNFRSF17 and ABCC1

Data Source: HiPPIP (Novel)

		TNFRSF17	ABCC1
Name		TNF receptor superfamily member 17	ATP binding cassette subfamily C member 1 (ABCC1 blood group)
Structure
GO Annotations	Cellular Component	Plasma Membrane Endomembrane System Membrane	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding Signaling Receptor Activity	Nucleotide Binding ATP Binding ABC-type Xenobiotic Transporter Activity ABC-type Vitamin B12 Transporter Activity ABC-type Glutathione S-conjugate Transporter Activity Efflux Transmembrane Transporter Activity Hydrolase Activity ATP Hydrolysis Activity Transmembrane Transporter Activity ATPase-coupled Lipid Transmembrane Transporter Activity Glutathione Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Sphingolipid Transporter Activity Carboxylic Acid Transmembrane Transporter Activity ABC-type Transporter Activity
	Biological Process	Adaptive Immune Response Lymphocyte Homeostasis Immune System Process Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway	Leukotriene Metabolic Process Xenobiotic Metabolic Process Lipid Transport Response To Xenobiotic Stimulus Cobalamin Transport Sphingolipid Biosynthetic Process Cellular Response To Oxidative Stress Glutathione Transmembrane Transport Heme Catabolic Process Xenobiotic Transport Phospholipid Translocation Carboxylic Acid Transport Positive Regulation Of Inflammatory Response Transmembrane Transport Cell Chemotaxis Transepithelial Transport Cyclic Nucleotide Transport Leukotriene Transport Monoatomic Anion Transmembrane Transport Sphingolipid Translocation Export Across Plasma Membrane Transport Across Blood-brain Barrier Cellular Response To Amyloid-beta Carboxylic Acid Transmembrane Transport Xenobiotic Transport Across Blood-brain Barrier
Pathways		TNFs bind their physiological receptors	Sphingolipid de novo biosynthesis Heme degradation Synthesis of Leukotrienes (LT) and Eoxins (EX) ABC-family proteins mediated transport Cytoprotection by HMOX1 Paracetamol ADME Transport of RCbl within the body NFE2L2 regulating MDR associated enzymes
Drugs		Belantamab mafodotin Teclistamab Idecabtagene vicleucel Ciltacabtagene autoleucel	ATP Sulfinpyrazone Biricodar Romidepsin Leukotriene C4
GWAS		Blood protein levels ( 30072576 ) Phenylephrine infusion rate during anesthesia ( 31455332 ) QT interval ( 19305408 ) Testicular germ cell tumor ( 26503584 )	Basophil count ( 32888494 ) Basophil percentage of white cells ( 32888494 ) Estimated glomerular filtration rate ( 31152163 ) Hip circumference adjusted for BMI ( 34021172 ) Ischemic stroke (undetermined subtype) ( 26708676 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular hemoglobin concentration ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Multiple myeloma (survival) ( 26198393 ) Pelvic organ prolapse (moderate/severe) ( 26545240 ) Psychosis proneness (perceptual aberration scale) ( 28525603 ) Rate of ventricular enlargement ( 31711042 ) Red cell distribution width ( 32888494 ) Response to antiepileptic mood-stabilizing treatment in bipolar disorder ( 32627186 ) Serum metabolite levels ( 33031748 ) Severe autoimmune type 2 diabetes ( 34737425 ) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683 ) White blood cell count (basophil) ( 27863252 )
Novel Interactors		1 novel interactors: ABCC1	1 novel interactors: TNFRSF17
Interacting Genes		8 interacting genes: CMTM7 PEX16 TMBIM6 TNFSF13 TNFSF13B TRAF1 TRAF2 TRAF3	7 interacting genes: ATP5F1A AZGP1 CSNK2A1 FILNC1 NPM1 NR3C1 TRAF3
Entrez ID		608	4363
HPRD ID		00144	01153
Ensembl ID		ENSG00000048462	ENSG00000103222
Uniprot IDs		Q02223	A0A7I2V2E0 P33527
PDB IDs		1OQD 1XU2 2KN1 4ZFO 6J7W 8HXQ 8HXR 8QY9 8QYA 8QYB	2CBZ 4C3Z 8VT4 8VUX 8VVC
GO Terms Enriched among Interactors		Tumor Necrosis Factor Receptor Binding Tumor Necrosis Factor-mediated Signaling Pathway Thioesterase Binding Regulation Of Immunoglobulin Production Signaling Adaptor Activity Ubiquitin Protein Ligase Binding CD40 Receptor Complex Cytokine-mediated Signaling Pathway Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Adaptive Immune Response Regulation Of DNA-binding Transcription Factor Activity Regulation Of Production Of Molecular Mediator Of Immune Response Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Adaptive Immune Response Cytokine Activity Positive Regulation Of Immune Response Positive Regulation Of B Cell Proliferation Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Canonical NF-kappaB Signal Transduction TORC2 Complex Disassembly Regulation Of B Cell Proliferation Lymphocyte Homeostasis ER-dependent Peroxisome Organization ER-dependent Peroxisome Localization ABC-type Vitamin B12 Transporter Activity ATPase-coupled Lipid Transmembrane Transporter Activity Sphingolipid Transporter Activity Cell Death Apoptotic Process Endoribonuclease Inhibitor Activity Regulation Of Apoptotic Signaling Pathway Programmed Cell Death Regulation Of Immune System Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Immune Response Protein Phosphatase Binding TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Leukocyte Homeostasis Positive Regulation Of B Cell Activation Positive Regulation Of Germinal Center Formation Transitional One Stage B Cell Differentiation B-1a B Cell Differentiation Positive Regulation Of Immune System Process Signal Transduction Immune System Process Positive Regulation Of DNA-binding Transcription Factor Activity Ubiquitin Ligase Complex	Core Promoter Sequence-specific DNA Binding Cellular Response To Dexamethasone Stimulus Response To Dexamethasone Hsp90 Protein Binding Macrophage Differentiation Adenyl Ribonucleotide Binding Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Tumor Necrosis Factor-mediated Signaling Pathway Nuclear Glucocorticoid Receptor Activity Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA Cellular Response To Steroid Hormone Stimulus Protein Kinase Binding Regulation Of Endoribonuclease Activity Regulation Of Translational Initiation Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Signal Transduction By P53 Class Mediator