SAV1 and RASSF1

Number of citations of the paper that reports this interaction (PMID 17379520)
43

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		SAV1	RASSF1
Gene Name		salvador family WW domain containing protein 1	Ras association (RalGDS/AF-6) domain family member 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Spindle Pole Nucleus Cytoplasm Microtubule Organizing Center Microtubule Plasma Membrane Microtubule Cytoskeleton
	Molecular Function	Protein Binding	Protein Binding Zinc Ion Binding Identical Protein Binding Protein N-terminus Binding
	Biological Process	Hair Follicle Development Keratinocyte Differentiation Hippo Signaling Positive Regulation Of Apoptotic Process Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Proliferation Ventricular Septum Morphogenesis Lung Epithelial Cell Differentiation Intestinal Epithelial Cell Differentiation Regulation Of Stem Cell Maintenance	Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Ras Protein Signal Transduction Positive Regulation Of Protein Ubiquitination Protein Stabilization Negative Regulation Of Cell Cycle Arrest
Pathways		Signaling by Hippo
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: EP300 RASSF1 STK3 STK4	33 interactors: ATP2B4 AURKA AURKB C7orf25 C8orf33 CDC20 CNKSR1 DAXX DDB1 E4F1 EXOSC8 HRAS IGFBP5 KCNE3 KDM1A MAP1B MAP1S MAPK8 MDM2 MOAP1 MST1 NUDT10 RASSF5 SAV1 STK3 STK4 SUV39H1 SUV39H2 TNFRSF10A TNFRSF1A TUBB TUBG1 XPA
Entrez ID		60485	11186
HPRD ID		06229	05470
Ensembl ID		ENSG00000151748	ENSG00000068028
Uniprot IDs		Q9H4B6	Q9NS23
PDB IDs			2KZU
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Binding Protein Stabilization Positive Regulation Of Binding Primitive Hemopoiesis Regulation Of Protein Stability Regulation Of Protein Binding Endocardium Development Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Binding Hippo Signaling Embryonic Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Negative Regulation Of Organ Growth Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Fat Cell Differentiation Intracellular Signal Transduction Heart Development Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Negative Regulation Of Developmental Growth Tube Development Regulation Of Organ Growth Chordate Embryonic Development Embryonic Placenta Development Positive Regulation Of Cellular Metabolic Process Embryo Development Ending In Birth Or Egg Hatching Histone H2B Acetylation Regulation Of Fat Cell Differentiation Neural Tube Formation Cardiovascular System Development Positive Regulation Of Protein Modification Process Embryonic Epithelial Tube Formation Epithelial Tube Formation Negative Regulation Of Canonical Wnt Signaling Pathway Apoptotic Process Tube Formation Programmed Cell Death Morphogenesis Of Embryonic Epithelium Anatomical Structure Formation Involved In Morphogenesis Cell Death Death Intrinsic Apoptotic Signaling Pathway Epithelium Development Placenta Development Negative Regulation Of Wnt Signaling Pathway Neural Tube Development Positive Regulation Of Cellular Protein Metabolic Process	Regulation Of Apoptotic Process Apoptotic Process Programmed Cell Death Regulation Of Cell Death Cell Death Death Regulation Of Protein Binding Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Apoptotic Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Binding Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Death Hippo Signaling Response To Abiotic Stimulus Mitotic Cell Cycle Process Positive Regulation Of Protein Modification Process Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Organ Growth Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Primitive Hemopoiesis Mitotic Cell Cycle Peptidyl-serine Phosphorylation Positive Regulation Of Transferase Activity Cell Cycle Response To UV Negative Regulation Of Protein Binding Signal Transduction By Phosphorylation Cellular Response To Stress Regulation Of Signaling Positive Regulation Of Protein Kinase Activity Organelle Organization Endocardium Development Positive Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Hepatocyte Apoptotic Process Positive Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Negative Regulation Of Gene Expression Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cell Cycle Process Response To Light Stimulus Negative Regulation Of Developmental Growth Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		adaptor contributing driving extensively flies gna11 gnaq gpcrs gq guan hippo lats1 malignancy mammals melanoma mob1 mst1 ocular oncogenes oncotarget opportunity persistently phosphorylates represents taz team uveal ww45 yap	bat braf cimp clinicopathological comparatively dapk develops discrete g15s gstp1 hierarchical hmlh1 inc india indian kras mint1 mint2 mint31 mononucleotide msi mss periodicals poorest rectal tp53 unfavorable v600e wiley
Tagcloud (Difference) ?		adaptor contributing driving extensively flies gna11 gnaq gpcrs gq guan hippo lats1 malignancy mammals melanoma mob1 mst1 ocular oncogenes oncotarget opportunity persistently phosphorylates represents taz team uveal ww45 yap	bat braf cimp clinicopathological comparatively dapk develops discrete g15s gstp1 hierarchical hmlh1 inc india indian kras mint1 mint2 mint31 mononucleotide msi mss periodicals poorest rectal tp53 unfavorable v600e wiley
Tagcloud (Intersection) ?