BRD2 and PHF1

		BRD2	PHF1
Description		bromodomain containing 2	PHD finger protein 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton ESC/E(Z) Complex Site Of Double-strand Break
	Molecular Function	Chromatin Binding Protein Serine/threonine Kinase Activity Protein Binding Protein-macromolecule Adaptor Activity Histone Binding Histone H4K12ac Reader Activity Histone H4K5ac Reader Activity Histone H3K14ac Reader Activity Acetylation-dependent Protein Binding	Transcription Corepressor Binding DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding Histone H3K4me3 Reader Activity Histone H3K36me3 Reader Activity Histone Methyltransferase Binding
	Biological Process	Neural Tube Closure Chromatin Organization Nucleosome Assembly Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Surface Receptor Signaling Pathway Via JAK-STAT Spermatogenesis Regulation Of Gene Expression Protein Localization To Chromatin T-helper 17 Cell Lineage Commitment Chromatin Looping Positive Regulation Of T-helper 17 Cell Lineage Commitment	Chromatin Organization DNA Damage Response Negative Regulation Of Gene Expression, Epigenetic DNA Repair-dependent Chromatin Remodeling
Pathways		RUNX3 regulates p14-ARF	PRC2 methylates histones and DNA
Drugs
Diseases
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 28008999) Feeling nervous ( 29500382) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 28008999) Ulcerative colitis ( 28008999)	Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Refractive error ( 32231278)
Interacting Genes		8 interacting genes: E2F1 E2F2 H2BC26 H4C16 MECOM PKNOX1 SPOP TOP1	77 interacting genes: ABI2 ARID5A ARRDC3 ATXN7L1 AVPI1 BHLHE40 BIRC7 BOLL CALCOCO2 CSTPP1 DISC1 DPF1 DYSF EFHC2 EZH2 FHL2 FOSB GOLGA6L9 GPKOW GPRASP3 H3C1 H3C10 H3C11 H3C12 H3C2 H3C3 H3C6 H3C7 H3C8 H4C1 HOMEZ HSD17B14 INCA1 IRAK1BP1 KIAA0408 KRT40 LBX1 LZTS2 MAGED1 MDFI MEOX2 MORN3 NAB2 NEK6 PATZ1 PDLIM7 PFDN5 PIBF1 PRR20A PRR20B PRR20C PRR20D PRR20E RBBP8NL RBPMS SMG9 SORBS3 SPAG8 TFCP2 TFIP11 THAP1 TLE5 TNS2 TOX2 TP53BP2 TRIM23 USP54 VAC14 ZBTB10 ZBTB16 ZIM2 ZNF500 ZNF526 ZNF688 ZNF71 ZRANB1 ZSCAN32
Entrez ID		6046	5252
HPRD ID		03326	04195
Ensembl ID		ENSG00000204256	ENSG00000112511
Uniprot IDs		A0A1U9X7A8 E9PIQ3 P25440 X5CF57	A0A140VJR4 A0A1U9X8A3 O43189
PDB IDs		1X0J 2DVQ 2DVR 2DVS 2DVV 2E3K 2G4A 2YDW 2YEK 3AQA 3ONI 4A9E 4A9F 4A9H 4A9I 4A9J 4A9M 4A9N 4A9O 4AKN 4ALG 4ALH 4J1P 4MR5 4MR6 4QEU 4QEV 4QEW 4UYF 4UYG 4UYH 5BT5 5DFB 5DFC 5DFD 5DW1 5EK9 5HEL 5HEM 5HEN 5HFQ 5IBN 5IG6 5N2L 5O38 5O39 5O3A 5O3B 5O3C 5O3D 5O3E 5O3F 5O3G 5O3H 5O3I 5S9O 5U5S 5U6V 5UEW 5XHE 5XHK 6CUI 6DB0 6DBC 6DDI 6DDJ 6E6J 6FFE 6FFF 6FFG 6I80 6I81 6JKE 6K04 6K05 6MO7 6MO8 6MO9 6MOA 6ONY 6SWO 6SWP 6TQ1 6TQ2 6U61 6U71 6U8H 6ULQ 6ULT 6VIY 6WWB 6YTM 6Z7F 6Z8P 6ZB0 6ZB1 6ZB2 7DPN 7DPO 7ENV 7ENZ 7EO5 7JX7 7L6D 7L9G 7L9J 7L9K 7LAK 7NPY 7NPZ 7NQ0 7NQ1 7NQ2 7NQ3 7NQ5 7NQ7 7NQ8 7NQ9 7NQI 7NQJ 7OE4 7OE5 7OE6 7OE8 7OE9 7OEP 7OER 7OES 7OET 7OGY 7Q5O 7USG 7USH 7USI 7UU0 7VRH 7VRI 7VRK 7VRM 7VRO 7VRQ 7VRZ 7VS0 7VS1 7VSF 7WLN 7WMQ 7WMU 7WN5 7WNA 7WNI 8B5G 8B5H 8B5I 8B5J 8CV7 8DNQ 8PX2 8PX8 8SB6 8WYG 8Z69 9FBX	2E5P 2M0O 4HCZ 5XFN 5XFO 5XFP 6WAT 6WAV 7LKY 8H43
Enriched GO Terms of Interacting Partners?		Lens Fiber Cell Apoptotic Process Rb-E2F Complex DNA Binding	Nucleosome Assembly Structural Constituent Of Chromatin Nucleosome Organization Telomere Organization Nucleosome Protein-DNA Complex Assembly Nucleus DNA Binding Protein Heterodimerization Activity Chromosome Organization Epigenetic Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Protein-containing Complex Protein Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Gene Expression Chromatin Remodeling Cadherin Binding Identical Protein Binding Regulation Of Transcription By RNA Polymerase II Chromosome Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Organization Transcription Factor Binding Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Corepressor Activity Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Transcription Corepressor Binding Protein-containing Complex Assembly Protein-containing Complex Organization
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