TTC3 and SHROOM2

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		TTC3	SHROOM2
Description		tetratricopeptide repeat domain 3	shroom family member 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol	Cytoplasm Cytoskeleton Microtubule Plasma Membrane Adherens Junction Bicellular Tight Junction Membrane Apical Plasma Membrane Cortical Actin Cytoskeleton Apical Junction Complex Extracellular Exosome Anchoring Junction
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Actin Binding Protein Binding Beta-catenin Binding Ligand-gated Sodium Channel Activity Actin Filament Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K48-linked Ubiquitination	Cell Morphogenesis Lens Morphogenesis In Camera-type Eye Actin Filament Organization Brain Development Eye Pigment Granule Organization Cell Migration Establishment Of Melanosome Localization Melanosome Organization Sodium Ion Transmembrane Transport Camera-type Eye Development Cellular Pigment Accumulation Ear Development Apical Protein Localization Camera-type Eye Morphogenesis Actin Filament Bundle Assembly
Pathways
Drugs
Diseases
GWAS		Eye color traits ( 20463881)	Colorectal cancer ( 22634755) Prostate cancer ( 23535732)
Interacting Genes		72 interacting genes: AKAP17A AKT1 APP ARID1A ATF7IP ATP2A2 ATP6V0A1 BLOC1S2 CADPS CADPS2 CEP290 CHUK CKAP2 CKAP5 COG4 COPS5 DAAM2 DLEU7 DSP DST EIF4G2 ETS2 EXOC4 FBXO7 FMNL2 FUT8 HARS1 HERC2 HSPB1 IFIT5 JADE2 JAK1 KANSL2 LCOR LRPAP1 MDH1 MIR7-1 MORF4L1 NR1D2 NR1H2 NUFIP1 PAX6 PBX2 PKNOX1 POLG PPFIBP1 PRKDC PSMD7 PSME1 RAI14 SH3BP5 SHROOM2 SMARCA4 SPARCL1 SPTAN1 SPTBN1 STXBP1 TAF1 THOP1 TJP1 TRAF6 TTN UBE2D2 UBE2E3 UBE3A UBR4 USP28 VHL WAC WHAMM XRN2 YWHAE	4 interacting genes: ACE2 RPS6KA1 TTC3 YWHAG
Entrez ID		7267	357
HPRD ID		03773	02113
Ensembl ID		ENSG00000182670	ENSG00000146950
Uniprot IDs		H7BZ57 P53804	B7Z682 F5H3B6 Q13796
PDB IDs			5F4Y 5F5P
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Protein-containing Complex Cytosol Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Protein Polyubiquitination Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Macromolecule Biosynthetic Process Protein Ubiquitination Post-translational Protein Modification Positive Regulation Of Biosynthetic Process Dense Core Granule Exocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle Establishment Of Vesicle Localization Protein K48-linked Ubiquitination Vesicle Localization Ubiquitin-protein Transferase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Calmodulin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein K11-linked Ubiquitination Organelle Localization Toll-like Receptor 4 Signaling Pathway Regulation Of Autophagy Regulation Of Gene Expression Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Cell Cycle Protein Modification Process Regulation Of Metabolic Process Enzyme Binding Intracellular Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Cadherin Binding Positive Regulation Of Macromolecule Metabolic Process Protein Localization To Cell-cell Junction Secretory Granule Localization Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Cellular Response To Stress Nucleoplasm Positive Regulation Of Protein Localization Regulation Of Cell Cycle Phase Transition Cell Cortex Regulation Of RNA Metabolic Process Golgi To Plasma Membrane Transport Ubiquitin-dependent Protein Catabolic Process Proteasome Complex	Regulation Of TOR Signaling Negative Regulation Of TOR Signaling Negative Regulation Of Intracellular Signal Transduction TOR Signaling TORC1 Signaling Positive Regulation Of L-proline Import Across Plasma Membrane Angiotensin-mediated Drinking Behavior Peptidyl-dipeptidase Activity Protein Kinase C Inhibitor Activity Entry Receptor-mediated Virion Attachment To Host Cell Protein Metabolic Process Viral Translation Viral Life Cycle Hepatocyte Proliferation Positive Regulation Of Hepatic Stellate Cell Activation Ribosomal Protein S6 Kinase Activity Protein Polyubiquitination Proteolysis Receptor-mediated Virion Attachment To Host Cell Tryptophan Transport Positive Regulation Of Gap Junction Assembly Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Phosphorylation-dependent Protein Binding Aromatic Amino Acid Transport Transporter Activator Activity Positive Regulation Of Cardiac Muscle Contraction Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Gap Junction Assembly Virion Attachment To Host Cell Drinking Behavior Adhesion Of Symbiont To Host Cell Receptor-mediated Endocytosis Of Virus By Host Cell Angiotensin Maturation Protein Modification Process Positive Regulation Of Cell Activation Negative Regulation Of Immune Response To Tumor Cell Adhesion Of Symbiont To Host Positive Regulation Of Striated Muscle Contraction Endocytosis Involved In Viral Entry Into Host Cell Positive Regulation Of Multicellular Organismal Process Regulation Of Translation Regulation Of T Cell Mediated Immune Response To Tumor Cell Insulin-like Growth Factor Receptor Binding Positive Regulation Of Immune Response To Tumor Cell Regulation Of Translation In Response To Stress Positive Regulation Of Amino Acid Transport
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