TTC3 and CEP290

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		TTC3	CEP290
Description		tetratricopeptide repeat domain 3	centrosomal protein 290
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol	Extracellular Region Nucleus Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cilium Membrane Cytoplasmic Vesicle Photoreceptor Connecting Cilium Protein-containing Complex Centriolar Satellite Specific Granule Lumen Ciliary Transition Zone MKS Complex Ciliary Basal Body Cell Projection
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Identical Protein Binding Microtubule Minus-end Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K48-linked Ubiquitination	Kidney Development Protein Transport Cell Projection Organization Hindbrain Development Otic Vesicle Formation Eye Photoreceptor Cell Development Camera-type Eye Development Positive Regulation Of DNA-templated Transcription Pronephros Development Cilium Assembly Regulation Of Establishment Of Protein Localization Positive Regulation Of Intracellular Protein Transport Ciliary Basal Body-plasma Membrane Docking Ciliary Transition Zone Assembly Non-motile Cilium Assembly
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Neutrophil degranulation AURKA Activation by TPX2
Drugs
Diseases			Meckel syndrome (MKS); Meckel-Gruber syndrome Bardet-Biedl syndrome (BBS) Leber congenital amaurosis (LCR) Senior-Loken syndrome Joubert syndrome
GWAS		Eye color traits ( 20463881)	Clozapine-induced agranulocytosis ( 25187353) Mild influenza (H1N1) infection ( 26379185)
Interacting Genes		72 interacting genes: AKAP17A AKT1 APP ARID1A ATF7IP ATP2A2 ATP6V0A1 BLOC1S2 CADPS CADPS2 CEP290 CHUK CKAP2 CKAP5 COG4 COPS5 DAAM2 DLEU7 DSP DST EIF4G2 ETS2 EXOC4 FBXO7 FMNL2 FUT8 HARS1 HERC2 HSPB1 IFIT5 JADE2 JAK1 KANSL2 LCOR LRPAP1 MDH1 MIR7-1 MORF4L1 NR1D2 NR1H2 NUFIP1 PAX6 PBX2 PKNOX1 POLG PPFIBP1 PRKDC PSMD7 PSME1 RAI14 SH3BP5 SHROOM2 SMARCA4 SPARCL1 SPTAN1 SPTBN1 STXBP1 TAF1 THOP1 TJP1 TRAF6 TTN UBE2D2 UBE2E3 UBE3A UBR4 USP28 VHL WAC WHAMM XRN2 YWHAE	7 interacting genes: BBLN CC2D2A CREBBP KIAA1328 MAPK10 PICK1 TTC3
Entrez ID		7267	80184
HPRD ID		03773
Ensembl ID		ENSG00000182670	ENSG00000198707
Uniprot IDs		H7BZ57 P53804	A0A6Q8PGB1 A0A6Q8PGP6 J3KNF5 O15078 Q05BJ6
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Protein-containing Complex Cytosol Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Protein Polyubiquitination Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Macromolecule Biosynthetic Process Protein Ubiquitination Post-translational Protein Modification Positive Regulation Of Biosynthetic Process Dense Core Granule Exocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle Establishment Of Vesicle Localization Protein K48-linked Ubiquitination Vesicle Localization Ubiquitin-protein Transferase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Calmodulin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein K11-linked Ubiquitination Organelle Localization Toll-like Receptor 4 Signaling Pathway Regulation Of Autophagy Regulation Of Gene Expression Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Cell Cycle Protein Modification Process Regulation Of Metabolic Process Enzyme Binding Intracellular Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Cadherin Binding Positive Regulation Of Macromolecule Metabolic Process Protein Localization To Cell-cell Junction Secretory Granule Localization Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Cellular Response To Stress Nucleoplasm Positive Regulation Of Protein Localization Regulation Of Cell Cycle Phase Transition Cell Cortex Regulation Of RNA Metabolic Process Golgi To Plasma Membrane Transport Ubiquitin-dependent Protein Catabolic Process Proteasome Complex
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