TTC3 and POLG

Number of citations of the paper that reports this interaction (PubMedID 29290964)
23

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		TTC3	POLG
Description		tetratricopeptide repeat domain 3	DNA polymerase gamma, catalytic subunit
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol	Mitochondrial Chromosome Mitochondrion Mitochondrial Matrix Gamma DNA Polymerase Complex Protein-containing Complex Mitochondrial Nucleoid
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protease Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity Protein Binding Single-stranded DNA 3'-5' DNA Exonuclease Activity 3'-5' Exonuclease Activity Transferase Activity Nucleotidyltransferase Activity Hydrolase Activity Lyase Activity DNA Polymerase Activity 5'-deoxyribose-5-phosphate Lyase Activity Catalytic Activity, Acting On A Nucleic Acid
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K48-linked Ubiquitination	DNA Metabolic Process DNA Replication DNA-templated DNA Replication Mitochondrial DNA Replication DNA Repair Base-excision Repair Base-excision Repair, Gap-filling DNA Replication Proofreading DNA Biosynthetic Process
Pathways			Strand-asynchronous mitochondrial DNA replication
Drugs
Diseases			Mitochondrial DNA depletion syndrome (MDS)
GWAS		Eye color traits ( 20463881)	Height ( 18193045) Menopause (age at onset) ( 22267201 26414677) Schizophrenia ( 28991256) Smoking status (ever vs never smokers) ( 30643258) Venlafaxine response in generalised anxiety disorder (responders vs non-responders after 24 weeks) ( 28437668)
Interacting Genes		72 interacting genes: AKAP17A AKT1 APP ARID1A ATF7IP ATP2A2 ATP6V0A1 BLOC1S2 CADPS CADPS2 CEP290 CHUK CKAP2 CKAP5 COG4 COPS5 DAAM2 DLEU7 DSP DST EIF4G2 ETS2 EXOC4 FBXO7 FMNL2 FUT8 HARS1 HERC2 HSPB1 IFIT5 JADE2 JAK1 KANSL2 LCOR LRPAP1 MDH1 MIR7-1 MORF4L1 NR1D2 NR1H2 NUFIP1 PAX6 PBX2 PKNOX1 POLG PPFIBP1 PRKDC PSMD7 PSME1 RAI14 SH3BP5 SHROOM2 SMARCA4 SPARCL1 SPTAN1 SPTBN1 STXBP1 TAF1 THOP1 TJP1 TRAF6 TTN UBE2D2 UBE2E3 UBE3A UBR4 USP28 VHL WAC WHAMM XRN2 YWHAE	5 interacting genes: MARCHF5 RBM11 SSBP1 TTC3 USP30
Entrez ID		7267	5428
HPRD ID		03773	01438
Ensembl ID		ENSG00000182670	ENSG00000140521
Uniprot IDs		H7BZ57 P53804	E5KNU5 P54098
PDB IDs			3IKM 4ZTU 4ZTZ 5C51 5C52 5C53 8D33 8D37 8D3R 8D42 8G5I 8G5J 8G5K 8G5L 8G5M 8G5N 8G5O 8G5P 8T7E 8UDK 8UDL 8V54 8V55 8V5D 8V5R
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Protein-containing Complex Cytosol Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Protein Polyubiquitination Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Macromolecule Biosynthetic Process Protein Ubiquitination Post-translational Protein Modification Positive Regulation Of Biosynthetic Process Dense Core Granule Exocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle Establishment Of Vesicle Localization Protein K48-linked Ubiquitination Vesicle Localization Ubiquitin-protein Transferase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Calmodulin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein K11-linked Ubiquitination Organelle Localization Toll-like Receptor 4 Signaling Pathway Regulation Of Autophagy Regulation Of Gene Expression Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Cell Cycle Protein Modification Process Regulation Of Metabolic Process Enzyme Binding Intracellular Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Cadherin Binding Positive Regulation Of Macromolecule Metabolic Process Protein Localization To Cell-cell Junction Secretory Granule Localization Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Cellular Response To Stress Nucleoplasm Positive Regulation Of Protein Localization Regulation Of Cell Cycle Phase Transition Cell Cortex Regulation Of RNA Metabolic Process Golgi To Plasma Membrane Transport Ubiquitin-dependent Protein Catabolic Process Proteasome Complex	Positive Regulation Of Helicase Activity Positive Regulation Of Mitochondrial DNA Replication Regulation Of Mitochondrion Organization Protein K48-linked Ubiquitination Peroxisomal Membrane Regulation Of Mitochondrial DNA Replication Protein K6-linked Deubiquitination Post-translational Protein Modification Regulation Of Mitochondrial DNA Metabolic Process Mitochondrial Outer Membrane Macromolecule Metabolic Process Positive Regulation Of CGAS/STING Signaling Pathway Protein Polyubiquitination Protein K11-linked Deubiquitination Negative Regulation Of Mitophagy
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?