RGS4 and GNAQ

Number of citations of the paper that reports this interaction (PMID 9405622)
53

Data Source:
HPRD (in vitro)

		RGS4	GNAQ
Gene Name		regulator of G-protein signaling 4	guanine nucleotide binding protein (G protein), q polypeptide
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Protein Complex	Cytoplasm Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Nuclear Membrane Extracellular Vesicular Exosome
	Molecular Function	G-protein Alpha-subunit Binding GTPase Activator Activity Calmodulin Binding	GTPase Activity Signal Transducer Activity GTPase Activator Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 2A Serotonin Receptor Binding Metal Ion Binding
	Biological Process	Inactivation Of MAPK Activity Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity	Skeletal System Development Action Potential Negative Regulation Of Protein Kinase Activity Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Glutamate Receptor Signaling Pathway Heart Development Blood Coagulation Post-embryonic Development Neuron Remodeling Forebrain Neuron Development Platelet Activation Regulation Of Catenin Import Into Nucleus Maternal Behavior Embryonic Digit Morphogenesis Positive Regulation Of GTPase Activity Regulation Of Melanocyte Differentiation Developmental Pigmentation Protein Stabilization Phospholipase C-activating Dopamine Receptor Signaling Pathway
Pathways		Signaling by GPCR GPCR downstream signaling G alpha (z) signalling events G alpha (i) signalling events	G alpha (q) signalling events Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Signaling by GPCR ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism Regulation of insulin secretion Signal amplification Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor Platelet activation, signaling and aggregation Free fatty acids regulate insulin secretion
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: CALM1 COPB1 COPB2 ERBB3 GABBR1 GNAI1 GNAI2 GNAO1 GNAQ KRIT1 PLCB1 PTAFR	48 interactors: ADHFE1 ADRA1B ADRBK1 AIP AKAP13 BDKRB1 BTK CCR5 CHRM3 CRHR1 CYTH1 CYTH2 FFAR1 FFAR2 GALR2 GRM2 GRM4 GRM7 HTR2A HTR2B HTR2C HTR6 KDR LUM MRGPRX1 NT5C3A PIK3CA PLCB1 PLCB2 PPT1 PTGIR RGS13 RGS16 RGS18 RGS2 RGS4 RGS5 RGS7 RIC8A RIC8B S1PR2 S1PR3 SLC9A3R1 TBXA2R TSHR TTC1 TUB VIPR1
Entrez ID		5999	2776
HPRD ID		03947	02998
Ensembl ID		ENSG00000117152
Uniprot IDs		P49798	P50148
PDB IDs
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Inositol Phosphate Metabolic Process Platelet Activation Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Cyclase Activity Synaptic Transmission Wound Healing Regulation Of CAMP Biosynthetic Process Signal Transduction Cell Activation Response To Wounding COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Regulation Of CAMP Metabolic Process G-protein Coupled Acetylcholine Receptor Signaling Pathway Golgi Vesicle Budding Signaling Cell Communication Regulation Of Phosphorus Metabolic Process Blood Coagulation Hemostasis Positive Regulation Of Catalytic Activity Cell-cell Signaling Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Gamma-aminobutyric Acid Signaling Pathway Negative Regulation Of CAMP Biosynthetic Process Cellular Response To Stimulus Vesicle Targeting, To, From Or Within Golgi Regulation Of Calcium Ion Transport Negative Regulation Of CAMP Metabolic Process Dopamine Receptor Signaling Pathway Intracellular Signal Transduction Vesicle Organization Regulation Of Body Fluid Levels Retrograde Vesicle-mediated Transport, Golgi To ER Negative Regulation Of Nucleotide Metabolic Process Negative Regulation Of Calcium Ion Transport Vesicle Targeting Localization Within Membrane Regulation Of Phosphorylation Activation Of Phospholipase C Activity Intra-Golgi Vesicle-mediated Transport Regulation Of Protein Kinase Activity Positive Regulation Of Phospholipase C Activity	G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Catalytic Activity Cell-cell Signaling Signal Transduction Signaling Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Signaling Cell Communication Positive Regulation Of Hydrolase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of GTPase Activity Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Stimulus Regulation Of Signal Transduction Single-organism Behavior Regulation Of Cellular Process Chemical Homeostasis Behavior Learning Or Memory Cytosolic Calcium Ion Homeostasis Cognition Calcium Ion Homeostasis Regulation Of Metabolic Process Ion Homeostasis Cellular Ion Homeostasis Synaptic Transmission Regulation Of Secretion Neurological System Process Cellular Chemical Homeostasis Cellular Calcium Ion Homeostasis Learning Cellular Cation Homeostasis Serotonin Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Phospholipase Activity Metal Ion Homeostasis Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol Biosynthetic Process Homeostatic Process Negative Regulation Of Signaling
Tagcloud ?		102kspsklsp109 adenylyl anandamide anticipated arrestin1 beta3 cb1 conform contraction endowed engage erk1 galphai galphaq gbetagamma gi grk5 k215r minigene mlc myosin mypt1 ptx rhoa rip ser103 ser108 signaled uncoupling	adaptor contributing driving extensively flies gna11 gpcrs gq guan hippo lats1 malignancy mammals melanoma mob1 mst1 ocular oncogenes oncotarget opportunity persistently phosphorylates represents sav1 taz team uveal ww45 yap
Tagcloud (Difference) ?		102kspsklsp109 adenylyl anandamide anticipated arrestin1 beta3 cb1 conform contraction endowed engage erk1 galphai galphaq gbetagamma gi grk5 k215r minigene mlc myosin mypt1 ptx rhoa rip ser103 ser108 signaled uncoupling	adaptor contributing driving extensively flies gna11 gpcrs gq guan hippo lats1 malignancy mammals melanoma mob1 mst1 ocular oncogenes oncotarget opportunity persistently phosphorylates represents sav1 taz team uveal ww45 yap
Tagcloud (Intersection) ?