RGS4 and UBR1

Number of citations of the paper that reports this interaction (PubMedID 34893540)
29

Data Source:
BioGRID (unspecified method)

		RGS4	UBR1
Description		regulator of G protein signaling 4	ubiquitin protein ligase E3 component n-recognin 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Protein-containing Complex	Ubiquitin Ligase Complex Proteasome Complex Cytoplasm Cytosol
	Molecular Function	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Calmodulin Binding Protein Kinase Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity L-leucine Binding
	Biological Process	Response To Amphetamine G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Heart Rate Response To Cocaine Response To Ethanol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion Transport Negative Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Actin Filament Organization Negative Regulation Of Glycine Import Across Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Dorsal Root Ganglion Development Positive Regulation Of Excitatory Postsynaptic Potential	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Negative Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To L-leucine Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway
Pathways		G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			Johanson-Blizzard syndrome
GWAS		Daytime nap ( 33568662) Response to fenofibrate (triglyceride levels) ( 27002377) Response to mTOR inhibitor (rapamycin) ( 24009623)	Appendicular lean mass ( 33097823) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) MGMT methylation in smokers ( 26183928) Triglycerides ( 25961943)
Interacting Genes		15 interacting genes: CALM1 COPB1 COPB2 EGFR ERBB3 GABBR1 GNAI1 GNAI2 GNAO1 GNAQ KCMF1 KRIT1 PLCB1 PTAFR UBR1	33 interacting genes: ANXA3 ARL15 ARL3 ARL4D ATF3 BCL2L1 BTBD2 CDC42 CDC6 COXFA4L2 DLEU1 DNAJB11 FOS FTH1 GADD45A GSK3B LAMA4 LAMTOR3 NR3C1 NTAN1 NTAQ1 NUDT3 PKNOX1 PLIN2 PTPRS RGS4 SERPINB9 SPRY2 TAC3 TP53I3 UBE2A UBE2B UBE2D2
Entrez ID		5999	197131
HPRD ID		03947	09342
Ensembl ID		ENSG00000117152	ENSG00000159459
Uniprot IDs		P49798	Q8IWV7
PDB IDs			3NY1 5TDC
Enriched GO Terms of Interacting Partners?		Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Secretion G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Positive Regulation Of Mitotic Cell Cycle Phase Transition Adenylate Cyclase Regulator Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Transport Plasma Membrane Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Acetylcholine Receptor Signaling Pathway Inositol Trisphosphate Metabolic Process Postsynaptic Signal Transduction Negative Regulation Of Secretion By Cell Regulation Of G1/S Transition Of Mitotic Cell Cycle Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Regulation Of Cell Cycle G1/S Phase Transition Cell Surface Receptor Signaling Pathway COPI Vesicle Coat Receptor Complex Regulation Of Secretion Regulation Of Peptide Hormone Secretion G Protein-coupled Receptor Binding G Protein Activity Membrane COPI-coated Vesicle Membrane Protein Tyrosine Kinase Activator Activity Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Cell Cycle Process GABA-ergic Synapse Positive Regulation Of Cell Cycle Process Regulation Of Hormone Secretion Purinergic Nucleotide Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission ERBB2 Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Response To Prostaglandin E Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Inositol Phosphate Metabolic Process Membrane Coat Protein Tyrosine Kinase Activity	Protein-N-terminal Asparagine Amidohydrolase Activity HULC Complex Ubiquitin Conjugating Enzyme Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
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