RGS3 and HIPK3

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
HPRD (two hybrid)

		RGS3	HIPK3
Gene Name		regulator of G-protein signaling 3	homeodomain interacting protein kinase 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Nucleus Cytoplasm PML Body
	Molecular Function	GTPase Activator Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity ATP Binding
	Biological Process	Inactivation Of MAPK Activity Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity	Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process MRNA Transcription Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		22 interactors: ACD APP CNKSR2 EFNB1 EFNB2 ESR1 GLS2 GNA11 GNAI3 GORASP2 GRIN2A HES4 HIPK3 MAPK12 PARK2 PAX6 PLSCR1 SCN5A YWHAB YWHAE YWHAQ YWHAZ	36 interactors: AR ARRB2 C1QA CREB1 DAXX FADD FAS FLNC GLUL GORASP1 GRB2 HEYL HNRNPA1 HNRNPA2B1 HNRNPH1 LIMD1 LIMK2 LIMS2 MBD1 MTMR4 NR2F2 RGS3 SIAH1 SIAH2 SKIL SNIP1 SRSF1 SRSF5 SUMO1 TGFB1I1 TOX4 TP73 TRA2B UBE2I ZNF107 ZYX
Entrez ID		5998	10114
HPRD ID		03720	05111
Ensembl ID		ENSG00000138835	ENSG00000110422
Uniprot IDs		B3KUB2 B3KVT7 B3KWG8 H7BXY1 P49796 Q53GP3 Q8NFN6	Q9H422
PDB IDs		2F5Y 2OJ4 3FBK
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mitochondrion Organization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway System Development Platelet Activation Cell-cell Signaling Positive Regulation Of Apoptotic Signaling Pathway Axon Guidance Multicellular Organismal Development Signaling Nervous System Development Anatomical Structure Development Cell Communication Response To Wounding Regulation Of Apoptotic Process Regulation Of Signaling Regulation Of Cell Death Regulation Of Cellular Process Axonogenesis Developmental Process Locomotion Axon Development Negative Regulation Of Protein Metabolic Process Negative Regulation Of Protein Dephosphorylation Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Apoptotic Process Response To Stress Positive Regulation Of Programmed Cell Death Chemotaxis Cellular Response To Stimulus Positive Regulation Of Cell Death Response To External Stimulus Apoptotic Process Neuron Projection Morphogenesis Regulation Of Catalytic Activity Programmed Cell Death Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Organelle Organization Cell Death Death Cell Surface Receptor Signaling Pathway Blood Coagulation Cell Morphogenesis Involved In Differentiation Hemostasis Positive Regulation Of Transport Response To Stimulus Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Transport	Regulation Of Signaling Regulation Of Signal Transduction Regulation Of RNA Metabolic Process RNA Metabolic Process Negative Regulation Of Biosynthetic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Cellular Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Component Assembly Negative Regulation Of Gene Expression Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Signaling Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Positive Regulation Of Signal Transduction Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Motor Neuron Apoptotic Process Transcription, DNA-templated Cellular Aromatic Compound Metabolic Process Protein Oligomerization RNA Biosynthetic Process Response To Organic Substance Cellular Response To Organic Substance RNA Splicing Regulation Of Extrinsic Apoptotic Signaling Pathway Viral Process Regulation Of RNA Splicing Cellular Metabolic Process RNA Processing Cellular Response To Growth Factor Stimulus Androgen Receptor Signaling Pathway Response To Growth Factor Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signaling Necroptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
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